Effects of serotype and species dependency of bacterial lipopolysaccharides in human melanocytes from lightly and darkly-pigmented skin
Lipopolysaccharides (LPS) alter melanin synthesis and induce cytokine secretion in melanocytes; however, effects of different serotypes or species of LPS have been rarely addressed. Herein, LPS from serotypes (O55:B5, O26:B6, O128:B12) of E Coli and P gingivalis (LPS-PG) was examined in human melano...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | BBA Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667160322000035 |
| _version_ | 1798016315273773056 |
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| author | Shilpi Goenka |
| author_facet | Shilpi Goenka |
| author_sort | Shilpi Goenka |
| collection | DOAJ |
| description | Lipopolysaccharides (LPS) alter melanin synthesis and induce cytokine secretion in melanocytes; however, effects of different serotypes or species of LPS have been rarely addressed. Herein, LPS from serotypes (O55:B5, O26:B6, O128:B12) of E Coli and P gingivalis (LPS-PG) was examined in human melanocytes of lightly-pigmented (LP) and darkly-pigmented (DP) donors. Results showed no effect of any LPS on melanin production in both cells. B6 and B12 elicited higher levels of IL-6 than B5 in LP cells while B6 was more potent than B12 in DP cells. B5 and PG did not show any effect on IL-6 in both cells. |
| first_indexed | 2024-04-11T15:48:54Z |
| format | Article |
| id | doaj.art-2e12005bd190489c94195ff0d518f311 |
| institution | Directory Open Access Journal |
| issn | 2667-1603 |
| language | English |
| last_indexed | 2024-04-11T15:48:54Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | BBA Advances |
| spelling | doaj.art-2e12005bd190489c94195ff0d518f3112022-12-22T04:15:26ZengElsevierBBA Advances2667-16032022-01-012100042Effects of serotype and species dependency of bacterial lipopolysaccharides in human melanocytes from lightly and darkly-pigmented skinShilpi Goenka0Department of Biochemistry and Cellular Biology, Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USALipopolysaccharides (LPS) alter melanin synthesis and induce cytokine secretion in melanocytes; however, effects of different serotypes or species of LPS have been rarely addressed. Herein, LPS from serotypes (O55:B5, O26:B6, O128:B12) of E Coli and P gingivalis (LPS-PG) was examined in human melanocytes of lightly-pigmented (LP) and darkly-pigmented (DP) donors. Results showed no effect of any LPS on melanin production in both cells. B6 and B12 elicited higher levels of IL-6 than B5 in LP cells while B6 was more potent than B12 in DP cells. B5 and PG did not show any effect on IL-6 in both cells.http://www.sciencedirect.com/science/article/pii/S2667160322000035Lipopolysaccharide serotypeE ColiP. Gingivalislightly-pigmentedDarkly-pigmentedIL-6 cytokine |
| spellingShingle | Shilpi Goenka Effects of serotype and species dependency of bacterial lipopolysaccharides in human melanocytes from lightly and darkly-pigmented skin BBA Advances Lipopolysaccharide serotype E Coli P. Gingivalis lightly-pigmented Darkly-pigmented IL-6 cytokine |
| title | Effects of serotype and species dependency of bacterial lipopolysaccharides in human melanocytes from lightly and darkly-pigmented skin |
| title_full | Effects of serotype and species dependency of bacterial lipopolysaccharides in human melanocytes from lightly and darkly-pigmented skin |
| title_fullStr | Effects of serotype and species dependency of bacterial lipopolysaccharides in human melanocytes from lightly and darkly-pigmented skin |
| title_full_unstemmed | Effects of serotype and species dependency of bacterial lipopolysaccharides in human melanocytes from lightly and darkly-pigmented skin |
| title_short | Effects of serotype and species dependency of bacterial lipopolysaccharides in human melanocytes from lightly and darkly-pigmented skin |
| title_sort | effects of serotype and species dependency of bacterial lipopolysaccharides in human melanocytes from lightly and darkly pigmented skin |
| topic | Lipopolysaccharide serotype E Coli P. Gingivalis lightly-pigmented Darkly-pigmented IL-6 cytokine |
| url | http://www.sciencedirect.com/science/article/pii/S2667160322000035 |
| work_keys_str_mv | AT shilpigoenka effectsofserotypeandspeciesdependencyofbacteriallipopolysaccharidesinhumanmelanocytesfromlightlyanddarklypigmentedskin |