High-Resolution Shear Wave Imaging of the Human Cornea Using a Dual-Element Transducer
Estimating the corneal elasticity can provide valuable information for corneal pathologies and treatments. Ophthalmologic pathologies will invariably cause changes to the elasticity of the cornea. For example, keratoconus and the phototoxic effects of ultraviolet radiation usually increase the corne...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-12-01
|
| Series: | Sensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8220/18/12/4244 |
| _version_ | 1817994399182749696 |
|---|---|
| author | Pei-Yu Chen Cho-Chiang Shih Wei-Chen Lin Teng Ma Qifa Zhou K. Kirk Shung Chih-Chung Huang |
| author_facet | Pei-Yu Chen Cho-Chiang Shih Wei-Chen Lin Teng Ma Qifa Zhou K. Kirk Shung Chih-Chung Huang |
| author_sort | Pei-Yu Chen |
| collection | DOAJ |
| description | Estimating the corneal elasticity can provide valuable information for corneal pathologies and treatments. Ophthalmologic pathologies will invariably cause changes to the elasticity of the cornea. For example, keratoconus and the phototoxic effects of ultraviolet radiation usually increase the corneal elasticity. This makes a quantitative estimation of the elasticity of the human cornea important for ophthalmic diagnoses. The present study investigated the use of a proposed high-resolution shear wave imaging (HR-SWI) method based on a dual-element transducer (comprising an 8-MHz element for pushing and a 32-MHz element for imaging) for measuring the group shear wave velocity (GSWV) of the human cornea. An empirical Young’s modulus formula was used to accurately convert the GSWV to Young’s modulus. Four quantitative parameters, bias, resolution, contrast, and contrast-to-noise ratio (CNR), were measured in gelatin phantoms with two different concentrations (3% and 7%) to evaluate the performance of HR-SWI. The biases of gelatin phantoms (3% and 7%) were 5.88% and 0.78%, respectively. The contrast and CNR were 0.76, 1.31 and 3.22, 2.43 for the two-side and two-layer phantoms, respectively. The measured image resolutions of HR-SWI in the lateral and axial directions were 72 and 140 μm, respectively. The calculated phase SWV (PSWV) and their corresponding Young’s modulus from six human donors were 2.45 ± 0.48 m/s (1600 Hz) and 11.52 ± 7.81 kPa, respectively. All the experimental results validated the concept of HR-SWI and its ability for measuring the human corneal elasticity. |
| first_indexed | 2024-04-14T01:51:23Z |
| format | Article |
| id | doaj.art-2e12ff10152c4c32b23f544ef99500c2 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-14T01:51:23Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-2e12ff10152c4c32b23f544ef99500c22022-12-22T02:19:19ZengMDPI AGSensors1424-82202018-12-011812424410.3390/s18124244s18124244High-Resolution Shear Wave Imaging of the Human Cornea Using a Dual-Element TransducerPei-Yu Chen0Cho-Chiang Shih1Wei-Chen Lin2Teng Ma3Qifa Zhou4K. Kirk Shung5Chih-Chung Huang6Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, TaiwanDepartment of Biomedical Engineering, National Cheng Kung University, Tainan 701, TaiwanDepartment of Microbiology and Immunology, National Cheng Kung University, Tainan 701, TaiwanDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USADepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USADepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USADepartment of Biomedical Engineering, National Cheng Kung University, Tainan 701, TaiwanEstimating the corneal elasticity can provide valuable information for corneal pathologies and treatments. Ophthalmologic pathologies will invariably cause changes to the elasticity of the cornea. For example, keratoconus and the phototoxic effects of ultraviolet radiation usually increase the corneal elasticity. This makes a quantitative estimation of the elasticity of the human cornea important for ophthalmic diagnoses. The present study investigated the use of a proposed high-resolution shear wave imaging (HR-SWI) method based on a dual-element transducer (comprising an 8-MHz element for pushing and a 32-MHz element for imaging) for measuring the group shear wave velocity (GSWV) of the human cornea. An empirical Young’s modulus formula was used to accurately convert the GSWV to Young’s modulus. Four quantitative parameters, bias, resolution, contrast, and contrast-to-noise ratio (CNR), were measured in gelatin phantoms with two different concentrations (3% and 7%) to evaluate the performance of HR-SWI. The biases of gelatin phantoms (3% and 7%) were 5.88% and 0.78%, respectively. The contrast and CNR were 0.76, 1.31 and 3.22, 2.43 for the two-side and two-layer phantoms, respectively. The measured image resolutions of HR-SWI in the lateral and axial directions were 72 and 140 μm, respectively. The calculated phase SWV (PSWV) and their corresponding Young’s modulus from six human donors were 2.45 ± 0.48 m/s (1600 Hz) and 11.52 ± 7.81 kPa, respectively. All the experimental results validated the concept of HR-SWI and its ability for measuring the human corneal elasticity.https://www.mdpi.com/1424-8220/18/12/4244human corneal elasticityhigh-resolution shear wave imaging (HR-SWI) |
| spellingShingle | Pei-Yu Chen Cho-Chiang Shih Wei-Chen Lin Teng Ma Qifa Zhou K. Kirk Shung Chih-Chung Huang High-Resolution Shear Wave Imaging of the Human Cornea Using a Dual-Element Transducer Sensors human corneal elasticity high-resolution shear wave imaging (HR-SWI) |
| title | High-Resolution Shear Wave Imaging of the Human Cornea Using a Dual-Element Transducer |
| title_full | High-Resolution Shear Wave Imaging of the Human Cornea Using a Dual-Element Transducer |
| title_fullStr | High-Resolution Shear Wave Imaging of the Human Cornea Using a Dual-Element Transducer |
| title_full_unstemmed | High-Resolution Shear Wave Imaging of the Human Cornea Using a Dual-Element Transducer |
| title_short | High-Resolution Shear Wave Imaging of the Human Cornea Using a Dual-Element Transducer |
| title_sort | high resolution shear wave imaging of the human cornea using a dual element transducer |
| topic | human corneal elasticity high-resolution shear wave imaging (HR-SWI) |
| url | https://www.mdpi.com/1424-8220/18/12/4244 |
| work_keys_str_mv | AT peiyuchen highresolutionshearwaveimagingofthehumancorneausingadualelementtransducer AT chochiangshih highresolutionshearwaveimagingofthehumancorneausingadualelementtransducer AT weichenlin highresolutionshearwaveimagingofthehumancorneausingadualelementtransducer AT tengma highresolutionshearwaveimagingofthehumancorneausingadualelementtransducer AT qifazhou highresolutionshearwaveimagingofthehumancorneausingadualelementtransducer AT kkirkshung highresolutionshearwaveimagingofthehumancorneausingadualelementtransducer AT chihchunghuang highresolutionshearwaveimagingofthehumancorneausingadualelementtransducer |