Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia
For both men and women, colorectal cancer (CRC) is the second leading cause of cancer death in the United States, primarily as a consequence of limited therapies for metastatic disease. The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor with diverse functions in detoxific...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/7/3/0847 |
| _version_ | 1797762379039113216 |
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| author | Guofeng Xie Jean-Pierre Raufman |
| author_facet | Guofeng Xie Jean-Pierre Raufman |
| author_sort | Guofeng Xie |
| collection | DOAJ |
| description | For both men and women, colorectal cancer (CRC) is the second leading cause of cancer death in the United States, primarily as a consequence of limited therapies for metastatic disease. The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor with diverse functions in detoxification of xenobiotics, inflammatory responses, and tissue homeostasis. Emerging evidence indicates that AhR also plays an important role in regulating intestinal cell proliferation and tumorigenesis. Here, we review both the pro- and anti-carcinogenic properties of AhR signaling and its potential role as a therapeutic target in CRC. |
| first_indexed | 2024-03-12T19:26:27Z |
| format | Article |
| id | doaj.art-2e1324ff67cb4369ac9779f3666c9cc9 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:26:27Z |
| publishDate | 2015-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-2e1324ff67cb4369ac9779f3666c9cc92023-08-02T04:49:47ZengMDPI AGCancers2072-66942015-07-01731436144610.3390/cancers7030847cancers7030847Role of the Aryl Hydrocarbon Receptor in Colon NeoplasiaGuofeng Xie0Jean-Pierre Raufman1Division of Gastroenterology and Hepatology, Veterans Administration Maryland Health Care System, University of Maryland School of Medicine, Baltimore, MD 21201, USADivision of Gastroenterology and Hepatology, Veterans Administration Maryland Health Care System, University of Maryland School of Medicine, Baltimore, MD 21201, USAFor both men and women, colorectal cancer (CRC) is the second leading cause of cancer death in the United States, primarily as a consequence of limited therapies for metastatic disease. The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor with diverse functions in detoxification of xenobiotics, inflammatory responses, and tissue homeostasis. Emerging evidence indicates that AhR also plays an important role in regulating intestinal cell proliferation and tumorigenesis. Here, we review both the pro- and anti-carcinogenic properties of AhR signaling and its potential role as a therapeutic target in CRC.http://www.mdpi.com/2072-6694/7/3/0847colorectal cancerTCDDaryl hydrocarbon receptorxenobiotics |
| spellingShingle | Guofeng Xie Jean-Pierre Raufman Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia Cancers colorectal cancer TCDD aryl hydrocarbon receptor xenobiotics |
| title | Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia |
| title_full | Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia |
| title_fullStr | Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia |
| title_full_unstemmed | Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia |
| title_short | Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia |
| title_sort | role of the aryl hydrocarbon receptor in colon neoplasia |
| topic | colorectal cancer TCDD aryl hydrocarbon receptor xenobiotics |
| url | http://www.mdpi.com/2072-6694/7/3/0847 |
| work_keys_str_mv | AT guofengxie roleofthearylhydrocarbonreceptorincolonneoplasia AT jeanpierreraufman roleofthearylhydrocarbonreceptorincolonneoplasia |