Magnetically Controlled Hyaluronic Acid–Maghemite Nanocomposites with Embedded Doxorubicin
The controllable delivery of drugs is a key task of pharmacology. For this purpose, a series of polymer composites was synthesized via the cross-linking of hyaluronate and a hyaluronate/polyacrylate mixture with Fe<sub>2</sub>O<sub>3</sub> nanoparticles. The cross-linking imp...
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MDPI AG
2023-09-01
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| Series: | Polymers |
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| author | Vasily Spiridonov Zukhra Zoirova Yuliya Alyokhina Nikolai Perov Mikhail Afanasov Denis Pozdyshev Daria Krjukova Alexander Knotko Vladimir Muronetz Alexander Yaroslavov |
| author_facet | Vasily Spiridonov Zukhra Zoirova Yuliya Alyokhina Nikolai Perov Mikhail Afanasov Denis Pozdyshev Daria Krjukova Alexander Knotko Vladimir Muronetz Alexander Yaroslavov |
| author_sort | Vasily Spiridonov |
| collection | DOAJ |
| description | The controllable delivery of drugs is a key task of pharmacology. For this purpose, a series of polymer composites was synthesized via the cross-linking of hyaluronate and a hyaluronate/polyacrylate mixture with Fe<sub>2</sub>O<sub>3</sub> nanoparticles. The cross-linking imparts magnetic properties to the composites, which are more pronounced for the ternary hyaluronate/polyacrylate/γ-Fe<sub>2</sub>O<sub>3</sub> composites compared with the binary hyaluronate/Fe<sub>2</sub>O<sub>3</sub> composites. When dispersed in water, the composites produce microsized hydrogel particles. Circulation of the ternary microgels in an aqueous solution at a speed of 1.84 cm/s can be stopped using a permanent external magnet with a magnetic flux density of 400 T. The composite hydrogels can absorb the antitumor antibiotic doxorubicin (Dox); the resulting constructs show their cytotoxicity to tumor cells to be comparable to the cytotoxicity of Dox itself. The addition of the hyaluronidase enzyme induces degradation of the binary and ternary microgels down to smaller particles. This study presents prospectives for the preparation of magnetically controlled biodegradable polymer carriers for the encapsulation of bioactive substances. |
| first_indexed | 2024-03-10T23:14:08Z |
| format | Article |
| id | doaj.art-2e1464b8d475418996a0dd011849bade |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T23:14:08Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-2e1464b8d475418996a0dd011849bade2023-11-19T08:44:28ZengMDPI AGPolymers2073-43602023-09-011517364410.3390/polym15173644Magnetically Controlled Hyaluronic Acid–Maghemite Nanocomposites with Embedded DoxorubicinVasily Spiridonov0Zukhra Zoirova1Yuliya Alyokhina2Nikolai Perov3Mikhail Afanasov4Denis Pozdyshev5Daria Krjukova6Alexander Knotko7Vladimir Muronetz8Alexander Yaroslavov9Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, RussiaFaculty of Materials Science, Lomonosov Moscow State University, Leninskie Gory 1-73, 119991 Moscow, RussiaDepartment of Physics, Lomonosov Moscow State University, Leninskie Gory 1-2, 119991 Moscow, RussiaDepartment of Physics, Lomonosov Moscow State University, Leninskie Gory 1-2, 119991 Moscow, RussiaDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, RussiaBelozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskye gory 1-40, 119992 Moscow, RussiaFaculty of Materials Science, Lomonosov Moscow State University, Leninskie Gory 1-73, 119991 Moscow, RussiaFaculty of Materials Science, Lomonosov Moscow State University, Leninskie Gory 1-73, 119991 Moscow, RussiaBelozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskye gory 1-40, 119992 Moscow, RussiaDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, RussiaThe controllable delivery of drugs is a key task of pharmacology. For this purpose, a series of polymer composites was synthesized via the cross-linking of hyaluronate and a hyaluronate/polyacrylate mixture with Fe<sub>2</sub>O<sub>3</sub> nanoparticles. The cross-linking imparts magnetic properties to the composites, which are more pronounced for the ternary hyaluronate/polyacrylate/γ-Fe<sub>2</sub>O<sub>3</sub> composites compared with the binary hyaluronate/Fe<sub>2</sub>O<sub>3</sub> composites. When dispersed in water, the composites produce microsized hydrogel particles. Circulation of the ternary microgels in an aqueous solution at a speed of 1.84 cm/s can be stopped using a permanent external magnet with a magnetic flux density of 400 T. The composite hydrogels can absorb the antitumor antibiotic doxorubicin (Dox); the resulting constructs show their cytotoxicity to tumor cells to be comparable to the cytotoxicity of Dox itself. The addition of the hyaluronidase enzyme induces degradation of the binary and ternary microgels down to smaller particles. This study presents prospectives for the preparation of magnetically controlled biodegradable polymer carriers for the encapsulation of bioactive substances.https://www.mdpi.com/2073-4360/15/17/3644magnetic polymer–iron oxide compositesbiopolymerenzymebiodegradabilitycytotoxicity |
| spellingShingle | Vasily Spiridonov Zukhra Zoirova Yuliya Alyokhina Nikolai Perov Mikhail Afanasov Denis Pozdyshev Daria Krjukova Alexander Knotko Vladimir Muronetz Alexander Yaroslavov Magnetically Controlled Hyaluronic Acid–Maghemite Nanocomposites with Embedded Doxorubicin Polymers magnetic polymer–iron oxide composites biopolymer enzyme biodegradability cytotoxicity |
| title | Magnetically Controlled Hyaluronic Acid–Maghemite Nanocomposites with Embedded Doxorubicin |
| title_full | Magnetically Controlled Hyaluronic Acid–Maghemite Nanocomposites with Embedded Doxorubicin |
| title_fullStr | Magnetically Controlled Hyaluronic Acid–Maghemite Nanocomposites with Embedded Doxorubicin |
| title_full_unstemmed | Magnetically Controlled Hyaluronic Acid–Maghemite Nanocomposites with Embedded Doxorubicin |
| title_short | Magnetically Controlled Hyaluronic Acid–Maghemite Nanocomposites with Embedded Doxorubicin |
| title_sort | magnetically controlled hyaluronic acid maghemite nanocomposites with embedded doxorubicin |
| topic | magnetic polymer–iron oxide composites biopolymer enzyme biodegradability cytotoxicity |
| url | https://www.mdpi.com/2073-4360/15/17/3644 |
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