Phytoconstituents, antioxidant, and cholinesterase inhibitory activities of the leaves and stem extracts of Artocarpus sericicarpus
The study aimed to investigate the antioxidant and cholinesterase inhibitory activities of the leaves and stems of Artocarpus sericicarpus and to analyse the phenolic compounds in the extracts. The modified Ellman’s method was used to determine the cholinesterase inhibitory activities against acetyl...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2024-02-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/112499/download/pdf/ |
| _version_ | 1797301044561051648 |
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| author | Suciati Suciati Erlinda Rhohmatul Laili Hamizah Haula Lidya Tumewu Nitra Nuengchamnong Nungruthai Suphrom Aty Widyawaruyanti |
| author_facet | Suciati Suciati Erlinda Rhohmatul Laili Hamizah Haula Lidya Tumewu Nitra Nuengchamnong Nungruthai Suphrom Aty Widyawaruyanti |
| author_sort | Suciati Suciati |
| collection | DOAJ |
| description | The study aimed to investigate the antioxidant and cholinesterase inhibitory activities of the leaves and stems of Artocarpus sericicarpus and to analyse the phenolic compounds in the extracts. The modified Ellman’s method was used to determine the cholinesterase inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. The antioxidant properties were evaluated using DPPH and ABTS methods. The total phenolic content (TPC) was measured by spectrometric assay, and compound identification was carried out by LC-MS/MS analysis. The results showed that the leaf and stem extracts of A. sericicarpus exerted significant inhibitory effects against AChE and BChE, as well as antioxidant activities. The stem ethanolic extract exhibited the highest potency against AChE and BChE with IC50 values of 5.81 and 11.46 µg/mL, respectively. The leaf and stem ethanolic extracts gave higher antioxidant activities and TPC compared to the water-based extracts. The LC-MS/MS analysis indicated the presence of phenolic compounds, such as flavones, flavonols, flavanones, prenylated chalcones, and xanthones in the extracts. |
| first_indexed | 2024-03-07T23:16:43Z |
| format | Article |
| id | doaj.art-2e15f64487364de9b8ac16d514235f29 |
| institution | Directory Open Access Journal |
| issn | 2603-557X |
| language | English |
| last_indexed | 2024-03-07T23:16:43Z |
| publishDate | 2024-02-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj.art-2e15f64487364de9b8ac16d514235f292024-02-21T10:41:14ZengPensoft PublishersPharmacia2603-557X2024-02-01711810.3897/pharmacia.71.e112499112499Phytoconstituents, antioxidant, and cholinesterase inhibitory activities of the leaves and stem extracts of Artocarpus sericicarpusSuciati Suciati0Erlinda Rhohmatul Laili1Hamizah Haula2Lidya Tumewu3Nitra Nuengchamnong4Nungruthai Suphrom5Aty Widyawaruyanti6Universitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaUniversitas AirlanggaNaresuan UniversityNaresuan UniversityUniversitas AirlanggaThe study aimed to investigate the antioxidant and cholinesterase inhibitory activities of the leaves and stems of Artocarpus sericicarpus and to analyse the phenolic compounds in the extracts. The modified Ellman’s method was used to determine the cholinesterase inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. The antioxidant properties were evaluated using DPPH and ABTS methods. The total phenolic content (TPC) was measured by spectrometric assay, and compound identification was carried out by LC-MS/MS analysis. The results showed that the leaf and stem extracts of A. sericicarpus exerted significant inhibitory effects against AChE and BChE, as well as antioxidant activities. The stem ethanolic extract exhibited the highest potency against AChE and BChE with IC50 values of 5.81 and 11.46 µg/mL, respectively. The leaf and stem ethanolic extracts gave higher antioxidant activities and TPC compared to the water-based extracts. The LC-MS/MS analysis indicated the presence of phenolic compounds, such as flavones, flavonols, flavanones, prenylated chalcones, and xanthones in the extracts.https://pharmacia.pensoft.net/article/112499/download/pdf/ |
| spellingShingle | Suciati Suciati Erlinda Rhohmatul Laili Hamizah Haula Lidya Tumewu Nitra Nuengchamnong Nungruthai Suphrom Aty Widyawaruyanti Phytoconstituents, antioxidant, and cholinesterase inhibitory activities of the leaves and stem extracts of Artocarpus sericicarpus Pharmacia |
| title | Phytoconstituents, antioxidant, and cholinesterase inhibitory activities of the leaves and stem extracts of Artocarpus sericicarpus |
| title_full | Phytoconstituents, antioxidant, and cholinesterase inhibitory activities of the leaves and stem extracts of Artocarpus sericicarpus |
| title_fullStr | Phytoconstituents, antioxidant, and cholinesterase inhibitory activities of the leaves and stem extracts of Artocarpus sericicarpus |
| title_full_unstemmed | Phytoconstituents, antioxidant, and cholinesterase inhibitory activities of the leaves and stem extracts of Artocarpus sericicarpus |
| title_short | Phytoconstituents, antioxidant, and cholinesterase inhibitory activities of the leaves and stem extracts of Artocarpus sericicarpus |
| title_sort | phytoconstituents antioxidant and cholinesterase inhibitory activities of the leaves and stem extracts of artocarpus sericicarpus |
| url | https://pharmacia.pensoft.net/article/112499/download/pdf/ |
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