Efficacy of mirabegron for ureteral stones: a systematic review with meta-analysis of randomized controlled trials
Background: Medical expulsive therapy demonstrates efficacy in managing ureteral stones in patients amenable to conservative interventions. This meta-analysis aims to evaluate the effectiveness of mirabegron in the treatment of ureteral stones.Methods: From conception to November 2023, we examined P...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1326600/full |
| _version_ | 1797384934830112768 |
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| author | Zhenguo Wang Junpeng Chi Yuhua Liu Jitao Wu Yuanshan Cui Chenchen Yang |
| author_facet | Zhenguo Wang Junpeng Chi Yuhua Liu Jitao Wu Yuanshan Cui Chenchen Yang |
| author_sort | Zhenguo Wang |
| collection | DOAJ |
| description | Background: Medical expulsive therapy demonstrates efficacy in managing ureteral stones in patients amenable to conservative interventions. This meta-analysis aims to evaluate the effectiveness of mirabegron in the treatment of ureteral stones.Methods: From conception to November 2023, we examined PubMed databases, the Cochrane Library, Embase, Ovid, Scopus, and trial registries for this systematic review and meta-analysis. We chose relevant randomized controlled trials (RCTs) evaluating the efficacy of mirabegron as an expulsive treatment for ureteral stones. The Cochrane risk of bias method was used to assess the quality of the evidence. Outcome measures, which included the stone expulsion rate (SER), expulsion time, and pain episodes, were analyzed using RevMan 5.4 and Stata 17.Results: Seven RCTs (N = 701) had enough information and were ultimately included. In patients with ureteral stones, mirabegron-treated patients had a substantially higher SER [odds ratio (OR) = 2.57, 95% confidence interval (CI) = 1.41–4.68, p = 0.002] than placebo-treated patients. Subgroup analysis revealed that mirabegron was superior to placebo in patients with small ureteral stones (OR = 2.26, 95% CI = 1.05–4.87, p = 0.04), with no heterogeneity between studies (p = 0.54; I2 = 0%). Mirabegron patients had a higher SER than the control group for distal ureteral stones (DUSs) (OR = 2.48, 95% CI = 1.31–4.68, p = 0.005). However, there was no difference in stone ejection time or pain episodes between groups.Conclusion: Mirabegron considerably improves SER in patients with ureteral stones, and the effect appears to be more pronounced for small and DUSs. Nevertheless, mirabegron treatment was not associated with improved stone expulsion time or pain management. |
| first_indexed | 2024-03-08T21:46:52Z |
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| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T21:46:52Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2e1835e988aa4ac1bae279349980d4cc2023-12-20T08:23:08ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-12-011410.3389/fphar.2023.13266001326600Efficacy of mirabegron for ureteral stones: a systematic review with meta-analysis of randomized controlled trialsZhenguo Wang0Junpeng Chi1Yuhua Liu2Jitao Wu3Yuanshan Cui4Chenchen Yang5Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, ChinaDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, ChinaDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, ChinaDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, ChinaDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, ChinaDepartment of Urology, Tengzhou Central People’s Hospital, Tengzhou, ChinaBackground: Medical expulsive therapy demonstrates efficacy in managing ureteral stones in patients amenable to conservative interventions. This meta-analysis aims to evaluate the effectiveness of mirabegron in the treatment of ureteral stones.Methods: From conception to November 2023, we examined PubMed databases, the Cochrane Library, Embase, Ovid, Scopus, and trial registries for this systematic review and meta-analysis. We chose relevant randomized controlled trials (RCTs) evaluating the efficacy of mirabegron as an expulsive treatment for ureteral stones. The Cochrane risk of bias method was used to assess the quality of the evidence. Outcome measures, which included the stone expulsion rate (SER), expulsion time, and pain episodes, were analyzed using RevMan 5.4 and Stata 17.Results: Seven RCTs (N = 701) had enough information and were ultimately included. In patients with ureteral stones, mirabegron-treated patients had a substantially higher SER [odds ratio (OR) = 2.57, 95% confidence interval (CI) = 1.41–4.68, p = 0.002] than placebo-treated patients. Subgroup analysis revealed that mirabegron was superior to placebo in patients with small ureteral stones (OR = 2.26, 95% CI = 1.05–4.87, p = 0.04), with no heterogeneity between studies (p = 0.54; I2 = 0%). Mirabegron patients had a higher SER than the control group for distal ureteral stones (DUSs) (OR = 2.48, 95% CI = 1.31–4.68, p = 0.005). However, there was no difference in stone ejection time or pain episodes between groups.Conclusion: Mirabegron considerably improves SER in patients with ureteral stones, and the effect appears to be more pronounced for small and DUSs. Nevertheless, mirabegron treatment was not associated with improved stone expulsion time or pain management.https://www.frontiersin.org/articles/10.3389/fphar.2023.1326600/fullmirabegronureteral stonesmedical expulsive therapyeffectivenessmeta-analysis |
| spellingShingle | Zhenguo Wang Junpeng Chi Yuhua Liu Jitao Wu Yuanshan Cui Chenchen Yang Efficacy of mirabegron for ureteral stones: a systematic review with meta-analysis of randomized controlled trials Frontiers in Pharmacology mirabegron ureteral stones medical expulsive therapy effectiveness meta-analysis |
| title | Efficacy of mirabegron for ureteral stones: a systematic review with meta-analysis of randomized controlled trials |
| title_full | Efficacy of mirabegron for ureteral stones: a systematic review with meta-analysis of randomized controlled trials |
| title_fullStr | Efficacy of mirabegron for ureteral stones: a systematic review with meta-analysis of randomized controlled trials |
| title_full_unstemmed | Efficacy of mirabegron for ureteral stones: a systematic review with meta-analysis of randomized controlled trials |
| title_short | Efficacy of mirabegron for ureteral stones: a systematic review with meta-analysis of randomized controlled trials |
| title_sort | efficacy of mirabegron for ureteral stones a systematic review with meta analysis of randomized controlled trials |
| topic | mirabegron ureteral stones medical expulsive therapy effectiveness meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1326600/full |
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