Case report: Complete response to pembrolizumab in a liver metastatic colon adenocarcinoma patient with a novel likely pathogenic germline MSH2 mutation

Case report: Complete response to pembrolizumab in a liver metastatic colon adenocarcinoma patient with a novel likely pathogenic germline MSH2 mutation

Lynch syndrome (LS) is a genetic disorder mainly caused by germline mutations in mismatched repair (MMR) genes (MSH2, MLH1, MSH6, and PMS2) or deletions of the epithelial cell adhesion molecule gene (EPCAM). A 43-year-old Chinese male patient underwent radical surgery and was pathologically confirme...

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Bibliographic Details
Main Authors: Yanjie Xu, Qin Li, Jiemin Zhao, Xuefeng Ni, Ping Li, Wenwei Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
Lynch syndrome
colorectal cancer
MSH2
germline mutation
PD-1 inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1064488/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1064488/full

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