Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice
Adhikari et al. use the redox modulatory abilities of citrate functionalized Mn3O4 nanoparticles to ameliorate oxidative damage in murine disease model of chronic kidney disease (CKD). This nanomedicine works by protecting structural and functional integrity of mitochondria from oxidative injury, re...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-08-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02546-8 |
| _version_ | 1818845224652242944 |
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| author | Aniruddha Adhikari Susmita Mondal Tanima Chatterjee Monojit Das Pritam Biswas Ria Ghosh Soumendra Darbar Hussain Alessa Jalal T. Althakafy Ali Sayqal Saleh A. Ahmed Anjan Kumar Das Maitree Bhattacharyya Samir Kumar Pal |
| author_facet | Aniruddha Adhikari Susmita Mondal Tanima Chatterjee Monojit Das Pritam Biswas Ria Ghosh Soumendra Darbar Hussain Alessa Jalal T. Althakafy Ali Sayqal Saleh A. Ahmed Anjan Kumar Das Maitree Bhattacharyya Samir Kumar Pal |
| author_sort | Aniruddha Adhikari |
| collection | DOAJ |
| description | Adhikari et al. use the redox modulatory abilities of citrate functionalized Mn3O4 nanoparticles to ameliorate oxidative damage in murine disease model of chronic kidney disease (CKD). This nanomedicine works by protecting structural and functional integrity of mitochondria from oxidative injury, reducing intracellular ROS, downregulating pro-inflammatory cytokines and maintaining cellular redox homeostasis. |
| first_indexed | 2024-12-19T05:26:16Z |
| format | Article |
| id | doaj.art-2e1b13424ead40f9aeabdec7b1deeefd |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-19T05:26:16Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-2e1b13424ead40f9aeabdec7b1deeefd2022-12-21T20:34:22ZengNature PortfolioCommunications Biology2399-36422021-08-014111510.1038/s42003-021-02546-8Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in miceAniruddha Adhikari0Susmita Mondal1Tanima Chatterjee2Monojit Das3Pritam Biswas4Ria Ghosh5Soumendra Darbar6Hussain Alessa7Jalal T. Althakafy8Ali Sayqal9Saleh A. Ahmed10Anjan Kumar Das11Maitree Bhattacharyya12Samir Kumar Pal13Department of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic SciencesDepartment of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic SciencesDepartment of Biochemistry, University of CalcuttaDepartment of Zoology, Uluberia College, University of Calcutta, UluberiaDepartment of Microbiology, St. Xavier’s CollegeDepartment of Biochemistry, University of CalcuttaResearch & Development Division, Dey’s Medical Stores (Mfg.) LtdDepartment of Chemistry, Faculty of Applied Sciences, Umm Al-Qura UniversityDepartment of Chemistry, Faculty of Applied Sciences, Umm Al-Qura UniversityDepartment of Chemistry, Faculty of Applied Sciences, Umm Al-Qura UniversityDepartment of Chemistry, Faculty of Applied Sciences, Umm Al-Qura UniversityDepartment of Pathology, Calcutta National Medical College and HospitalDepartment of Biochemistry, University of CalcuttaDepartment of Chemical, Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic SciencesAdhikari et al. use the redox modulatory abilities of citrate functionalized Mn3O4 nanoparticles to ameliorate oxidative damage in murine disease model of chronic kidney disease (CKD). This nanomedicine works by protecting structural and functional integrity of mitochondria from oxidative injury, reducing intracellular ROS, downregulating pro-inflammatory cytokines and maintaining cellular redox homeostasis.https://doi.org/10.1038/s42003-021-02546-8 |
| spellingShingle | Aniruddha Adhikari Susmita Mondal Tanima Chatterjee Monojit Das Pritam Biswas Ria Ghosh Soumendra Darbar Hussain Alessa Jalal T. Althakafy Ali Sayqal Saleh A. Ahmed Anjan Kumar Das Maitree Bhattacharyya Samir Kumar Pal Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice Communications Biology |
| title | Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice |
| title_full | Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice |
| title_fullStr | Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice |
| title_full_unstemmed | Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice |
| title_short | Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice |
| title_sort | redox nanomedicine ameliorates chronic kidney disease ckd by mitochondrial reconditioning in mice |
| url | https://doi.org/10.1038/s42003-021-02546-8 |
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