Performance of the SAEM and FOCEI Algorithms in the Open‐Source, Nonlinear Mixed Effect Modeling Tool nlmixr

Performance of the SAEM and FOCEI Algorithms in the Open‐Source, Nonlinear Mixed Effect Modeling Tool nlmixr

The free and open‐source package nlmixr implements pharmacometric nonlinear mixed effects model parameter estimation in R. It provides a uniform language to define pharmacometric models using ordinary differential equations. Performances of the stochastic approximation expectation‐maximization (SAEM...

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Bibliographic Details
Main Authors: Rik Schoemaker, Matthew Fidler, Christian Laveille, Justin J. Wilkins, Richard Hooijmaijers, Teun M. Post, Mirjam N. Trame, Yuan Xiong, Wenping Wang
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.12471

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