Initial and sustained brain responses to threat anticipation in blood-injection-injury phobia
Blood-injection-injury (BII) phobia differs from other subtypes of specific phobia in that it is associated with elevated disgust-sensitivity as well as specific autonomic and brain responses during processing of phobia-relevant stimuli. To what extent these features play a role already during threa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158216302522 |
| _version_ | 1828878492359458816 |
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| author | Leonie Brinkmann Hendrik Poller Martin J. Herrmann Wolfgang Miltner Thomas Straube |
| author_facet | Leonie Brinkmann Hendrik Poller Martin J. Herrmann Wolfgang Miltner Thomas Straube |
| author_sort | Leonie Brinkmann |
| collection | DOAJ |
| description | Blood-injection-injury (BII) phobia differs from other subtypes of specific phobia in that it is associated with elevated disgust-sensitivity as well as specific autonomic and brain responses during processing of phobia-relevant stimuli. To what extent these features play a role already during threat anticipation is unclear. In the current fMRI experiment, 16 female BII phobics and 16 female healthy controls anticipated the presentation of phobia-specific and neutral pictures. On the behavioral level, anxiety dominated the anticipatory period in BII phobics relative to controls, while both anxiety and disgust were elevated during picture presentation. By applying two different models for the analysis of brain responses to anticipation of phobia-specific versus neutral stimuli, we found initial and sustained increases of activation in anterior cingulate cortex (ACC), insula, lateral and medial prefrontal cortex (PFC), thalamus and visual areas, as well as initial activation in the amygdala for BII phobics as compared to healthy controls. These results suggest that BII phobia is characterized by activation of a typical neural defense network during threat anticipation, with anxiety as the predominant emotion. |
| first_indexed | 2024-12-13T09:06:38Z |
| format | Article |
| id | doaj.art-2e1ca26619d144d28c81eabf5016b419 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-13T09:06:38Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-2e1ca26619d144d28c81eabf5016b4192022-12-21T23:53:03ZengElsevierNeuroImage: Clinical2213-15822017-01-0113C32032910.1016/j.nicl.2016.12.015Initial and sustained brain responses to threat anticipation in blood-injection-injury phobiaLeonie Brinkmann0Hendrik Poller1Martin J. Herrmann2Wolfgang Miltner3Thomas Straube4Institute of Medical Psychology and Systems Neuroscience, University of Muenster, Von-Esmarch-Str. 52, D-48149 Muenster, GermanyDepartment of Biological and Clinical Psychology, Friedrich-Schiller-University Jena, Am Steiger 3, D-07743 Jena, GermanyLaboratory of Psychophysiology and Functional Imaging, University Hospital Wuerzburg, Fuechsleinstraße 15, D-97080 Wuerzburg, GermanyDepartment of Biological and Clinical Psychology, Friedrich-Schiller-University Jena, Am Steiger 3, D-07743 Jena, GermanyInstitute of Medical Psychology and Systems Neuroscience, University of Muenster, Von-Esmarch-Str. 52, D-48149 Muenster, GermanyBlood-injection-injury (BII) phobia differs from other subtypes of specific phobia in that it is associated with elevated disgust-sensitivity as well as specific autonomic and brain responses during processing of phobia-relevant stimuli. To what extent these features play a role already during threat anticipation is unclear. In the current fMRI experiment, 16 female BII phobics and 16 female healthy controls anticipated the presentation of phobia-specific and neutral pictures. On the behavioral level, anxiety dominated the anticipatory period in BII phobics relative to controls, while both anxiety and disgust were elevated during picture presentation. By applying two different models for the analysis of brain responses to anticipation of phobia-specific versus neutral stimuli, we found initial and sustained increases of activation in anterior cingulate cortex (ACC), insula, lateral and medial prefrontal cortex (PFC), thalamus and visual areas, as well as initial activation in the amygdala for BII phobics as compared to healthy controls. These results suggest that BII phobia is characterized by activation of a typical neural defense network during threat anticipation, with anxiety as the predominant emotion.http://www.sciencedirect.com/science/article/pii/S2213158216302522fMRIAmygdalaBed nucleus of the stria terminalis (BNST)InsulaAnterior cingulate cortex |
| spellingShingle | Leonie Brinkmann Hendrik Poller Martin J. Herrmann Wolfgang Miltner Thomas Straube Initial and sustained brain responses to threat anticipation in blood-injection-injury phobia NeuroImage: Clinical fMRI Amygdala Bed nucleus of the stria terminalis (BNST) Insula Anterior cingulate cortex |
| title | Initial and sustained brain responses to threat anticipation in blood-injection-injury phobia |
| title_full | Initial and sustained brain responses to threat anticipation in blood-injection-injury phobia |
| title_fullStr | Initial and sustained brain responses to threat anticipation in blood-injection-injury phobia |
| title_full_unstemmed | Initial and sustained brain responses to threat anticipation in blood-injection-injury phobia |
| title_short | Initial and sustained brain responses to threat anticipation in blood-injection-injury phobia |
| title_sort | initial and sustained brain responses to threat anticipation in blood injection injury phobia |
| topic | fMRI Amygdala Bed nucleus of the stria terminalis (BNST) Insula Anterior cingulate cortex |
| url | http://www.sciencedirect.com/science/article/pii/S2213158216302522 |
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