Isolation, Characterization and Pharmacological Investigations of a New Phenolic Compound along with Four Others Firstly Reported Phytochemicals from <i>Glycosmis cyanocarpa</i> (Blume) Spreng
Plants are serving the mankind with important bioactive phytochemicals from the very ancient ages to develop novel therapeutics against different disease states. <i>Glycosmis cyanocarpa</i> (Blume) Spreng is a plant from the Rutaceae family and a very less explored species from the Glyco...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/18/5972 |
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| author | Sania Ashrafi Safaet Alam Nazim Uddin Emon Monira Ahsan |
| author_facet | Sania Ashrafi Safaet Alam Nazim Uddin Emon Monira Ahsan |
| author_sort | Sania Ashrafi |
| collection | DOAJ |
| description | Plants are serving the mankind with important bioactive phytochemicals from the very ancient ages to develop novel therapeutics against different disease states. <i>Glycosmis cyanocarpa</i> (Blume) Spreng is a plant from the Rutaceae family and a very less explored species from the Glycosmis genus. Thus, this present study was intended to present the chemical and biological investigation of <i>Glycosmis cyanocarpa</i> (Blume) Spreng. The chemical investigation resulted in the isolation of one new phenolic compound to the best of our knowledge which is (4-(3-hydroxy-2-methylpropyl)-2-methoxyphenol) (<b>1</b>) along with four known compounds that are isolated for the first time from this species- 3-methyl-1<i>H</i>-indole (<b>2</b>), Tri-<i>trans</i>poly-<i>cis</i> prenol-12 (<b>3</b>), Stigmasterol (<b>4</b>) and β-sitosterol (<b>5</b>). Their chemical structures were elucidated based on extensive spectroscopic methods, including 1D and 2D NMR, and comparison with the available literature data. Isolated phytochemicals were further investigated to unveil their antioxidant properties with IC<sub>50</sub> values (ranged from 9.97–75.48 µg/mL), cytotoxicity with LC<sub>50</sub> values (ranged from 1.02–1.92 µg/mL), and antibacterial properties against some selected Gram (+) ve and Gram (−) ve bacteria. Among the compounds, 3-methyl-1<i>H</i>-indole (<b>2</b>) was found to be the most active against <i>Staphylococcus aureus</i>. Moreover, the phenolic compound (<b>1</b>) and the alkaloid (<b>2</b>) revealed the highest antioxidant (9.97 µg/mL) and cytotoxic activities (1.02 µg/mL), respectively. Thus, the isolation of these bioactive phytochemicals from the plant revealed a new perception in the study arena of drug discovery and the findings may ease the development and discovery of novel therapeutics. Further investigations are still recommended to understand their exact molecular mechanism and toxicological impact. |
| first_indexed | 2024-03-09T23:00:48Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T23:00:48Z |
| publishDate | 2022-09-01 |
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| series | Molecules |
| spelling | doaj.art-2e1f4e99a68245d68f0ccb34eeb98d9c2023-11-23T18:02:07ZengMDPI AGMolecules1420-30492022-09-012718597210.3390/molecules27185972Isolation, Characterization and Pharmacological Investigations of a New Phenolic Compound along with Four Others Firstly Reported Phytochemicals from <i>Glycosmis cyanocarpa</i> (Blume) SprengSania Ashrafi0Safaet Alam1Nazim Uddin Emon2Monira Ahsan3Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, BangladeshDepartment of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, BangladeshDepartment of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Chittagong 4318, BangladeshDepartment of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, BangladeshPlants are serving the mankind with important bioactive phytochemicals from the very ancient ages to develop novel therapeutics against different disease states. <i>Glycosmis cyanocarpa</i> (Blume) Spreng is a plant from the Rutaceae family and a very less explored species from the Glycosmis genus. Thus, this present study was intended to present the chemical and biological investigation of <i>Glycosmis cyanocarpa</i> (Blume) Spreng. The chemical investigation resulted in the isolation of one new phenolic compound to the best of our knowledge which is (4-(3-hydroxy-2-methylpropyl)-2-methoxyphenol) (<b>1</b>) along with four known compounds that are isolated for the first time from this species- 3-methyl-1<i>H</i>-indole (<b>2</b>), Tri-<i>trans</i>poly-<i>cis</i> prenol-12 (<b>3</b>), Stigmasterol (<b>4</b>) and β-sitosterol (<b>5</b>). Their chemical structures were elucidated based on extensive spectroscopic methods, including 1D and 2D NMR, and comparison with the available literature data. Isolated phytochemicals were further investigated to unveil their antioxidant properties with IC<sub>50</sub> values (ranged from 9.97–75.48 µg/mL), cytotoxicity with LC<sub>50</sub> values (ranged from 1.02–1.92 µg/mL), and antibacterial properties against some selected Gram (+) ve and Gram (−) ve bacteria. Among the compounds, 3-methyl-1<i>H</i>-indole (<b>2</b>) was found to be the most active against <i>Staphylococcus aureus</i>. Moreover, the phenolic compound (<b>1</b>) and the alkaloid (<b>2</b>) revealed the highest antioxidant (9.97 µg/mL) and cytotoxic activities (1.02 µg/mL), respectively. Thus, the isolation of these bioactive phytochemicals from the plant revealed a new perception in the study arena of drug discovery and the findings may ease the development and discovery of novel therapeutics. Further investigations are still recommended to understand their exact molecular mechanism and toxicological impact.https://www.mdpi.com/1420-3049/27/18/5972<i>Glycosmis cyanocarpa</i>phytochemicalNMRantioxidantcytotoxicityantibacterial |
| spellingShingle | Sania Ashrafi Safaet Alam Nazim Uddin Emon Monira Ahsan Isolation, Characterization and Pharmacological Investigations of a New Phenolic Compound along with Four Others Firstly Reported Phytochemicals from <i>Glycosmis cyanocarpa</i> (Blume) Spreng Molecules <i>Glycosmis cyanocarpa</i> phytochemical NMR antioxidant cytotoxicity antibacterial |
| title | Isolation, Characterization and Pharmacological Investigations of a New Phenolic Compound along with Four Others Firstly Reported Phytochemicals from <i>Glycosmis cyanocarpa</i> (Blume) Spreng |
| title_full | Isolation, Characterization and Pharmacological Investigations of a New Phenolic Compound along with Four Others Firstly Reported Phytochemicals from <i>Glycosmis cyanocarpa</i> (Blume) Spreng |
| title_fullStr | Isolation, Characterization and Pharmacological Investigations of a New Phenolic Compound along with Four Others Firstly Reported Phytochemicals from <i>Glycosmis cyanocarpa</i> (Blume) Spreng |
| title_full_unstemmed | Isolation, Characterization and Pharmacological Investigations of a New Phenolic Compound along with Four Others Firstly Reported Phytochemicals from <i>Glycosmis cyanocarpa</i> (Blume) Spreng |
| title_short | Isolation, Characterization and Pharmacological Investigations of a New Phenolic Compound along with Four Others Firstly Reported Phytochemicals from <i>Glycosmis cyanocarpa</i> (Blume) Spreng |
| title_sort | isolation characterization and pharmacological investigations of a new phenolic compound along with four others firstly reported phytochemicals from i glycosmis cyanocarpa i blume spreng |
| topic | <i>Glycosmis cyanocarpa</i> phytochemical NMR antioxidant cytotoxicity antibacterial |
| url | https://www.mdpi.com/1420-3049/27/18/5972 |
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