Proteinuria is independently associated with carotid atherosclerosis: a multicentric study
Abstract Background and aims Atherosclerosis is a vital cause of cardiovascular diseases. The correlation between proteinuria and atherosclerosis, however, has not been confirmed. This study aimed to assess whether there is a relationship between proteinuria and atherosclerosis. Methods From January...
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-021-02367-x |
| _version_ | 1818345118742085632 |
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| author | Wencai Jiang Meixiang Chen Jianyu Huang Yu Shang Changyu Qin Zheng Ruan Shuang Li Ruixin Wang Pengfei Li Yuekang Huang Jianxiong Liu Lin Xu |
| author_facet | Wencai Jiang Meixiang Chen Jianyu Huang Yu Shang Changyu Qin Zheng Ruan Shuang Li Ruixin Wang Pengfei Li Yuekang Huang Jianxiong Liu Lin Xu |
| author_sort | Wencai Jiang |
| collection | DOAJ |
| description | Abstract Background and aims Atherosclerosis is a vital cause of cardiovascular diseases. The correlation between proteinuria and atherosclerosis, however, has not been confirmed. This study aimed to assess whether there is a relationship between proteinuria and atherosclerosis. Methods From January 2016 to September 2020, 13,545 asymptomatic subjects from four centres in southern China underwent dipstick proteinuria testing and carotid atherosclerosis examination. Data on demography and past medical history were collected, and laboratory examinations were performed. The samples consisted of 7405 subjects (4875 males and 2530 females), excluding subjects failing to reach predefined standards and containing enough information. A multivariate logistic regression model was used to adjust the influence of traditional risk factors for atherosclerosis on the results. Results Compared with proteinuria-negative subjects, proteinuria-positive subjects had a higher prevalence rate of carotid atherosclerosis. The differences were statistically significant (22.6% vs. 26.7%, χ2 = 10.03, p = 0.002). After adjusting for common risk factors for atherosclerosis, age, sex, BMI, blood lipids, blood pressure, renal function, hypertensive disease, diabetes mellitus and hyperlipidaemia, proteinuria was an independent risk factor for atherosclerosis (OR = 1.191, 95% CI 1.015–1.398, p = 0.033). The Hosmer–Lemeshow test was used to test the risk prediction model of atherosclerosis, and the results showed that the model has high goodness of fit and strong independent variable prediction ability. Conclusions Proteinuria is independently related to carotid atherosclerosis. With the increase in proteinuria level, the risk of carotid atherosclerotic plaque increases. For patients with positive proteinuria, further examination of atherosclerosis should not be ignored. |
| first_indexed | 2024-12-13T16:57:18Z |
| format | Article |
| id | doaj.art-2e1facb2db6d4ac698342a0ee73cb395 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-13T16:57:18Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-2e1facb2db6d4ac698342a0ee73cb3952022-12-21T23:37:52ZengBMCBMC Cardiovascular Disorders1471-22612021-11-0121111010.1186/s12872-021-02367-xProteinuria is independently associated with carotid atherosclerosis: a multicentric studyWencai Jiang0Meixiang Chen1Jianyu Huang2Yu Shang3Changyu Qin4Zheng Ruan5Shuang Li6Ruixin Wang7Pengfei Li8Yuekang Huang9Jianxiong Liu10Lin Xu11Department of Cardiology, Chengdu Second People’s HospitalThe First School of Clinical Medicine, Southern Medical UniversityDepartment of Geratic Cardiology, General Hospital of the Southern Theatre CommandThe People’s Hospital of WenchuanThe First School of Clinical Medicine, Southern Medical UniversityThe First Affiliated Hospital of Guangdong Pharmaceutical UniversitySchool of Automation, Guangdong University of TechnologyThe First Affiliated Hospital of Guangdong Pharmaceutical UniversityThe First School of Clinical Medicine, Southern Medical UniversityThe First School of Clinical Medicine, Southern Medical UniversityDepartment of Cardiology, Chengdu Second People’s HospitalThe First Affiliated Hospital of Guangdong Pharmaceutical UniversityAbstract Background and aims Atherosclerosis is a vital cause of cardiovascular diseases. The correlation between proteinuria and atherosclerosis, however, has not been confirmed. This study aimed to assess whether there is a relationship between proteinuria and atherosclerosis. Methods From January 2016 to September 2020, 13,545 asymptomatic subjects from four centres in southern China underwent dipstick proteinuria testing and carotid atherosclerosis examination. Data on demography and past medical history were collected, and laboratory examinations were performed. The samples consisted of 7405 subjects (4875 males and 2530 females), excluding subjects failing to reach predefined standards and containing enough information. A multivariate logistic regression model was used to adjust the influence of traditional risk factors for atherosclerosis on the results. Results Compared with proteinuria-negative subjects, proteinuria-positive subjects had a higher prevalence rate of carotid atherosclerosis. The differences were statistically significant (22.6% vs. 26.7%, χ2 = 10.03, p = 0.002). After adjusting for common risk factors for atherosclerosis, age, sex, BMI, blood lipids, blood pressure, renal function, hypertensive disease, diabetes mellitus and hyperlipidaemia, proteinuria was an independent risk factor for atherosclerosis (OR = 1.191, 95% CI 1.015–1.398, p = 0.033). The Hosmer–Lemeshow test was used to test the risk prediction model of atherosclerosis, and the results showed that the model has high goodness of fit and strong independent variable prediction ability. Conclusions Proteinuria is independently related to carotid atherosclerosis. With the increase in proteinuria level, the risk of carotid atherosclerotic plaque increases. For patients with positive proteinuria, further examination of atherosclerosis should not be ignored.https://doi.org/10.1186/s12872-021-02367-xAtherosclerosisProteinuriaCardiovascular diseasesRisk factorsEpidemiology |
| spellingShingle | Wencai Jiang Meixiang Chen Jianyu Huang Yu Shang Changyu Qin Zheng Ruan Shuang Li Ruixin Wang Pengfei Li Yuekang Huang Jianxiong Liu Lin Xu Proteinuria is independently associated with carotid atherosclerosis: a multicentric study BMC Cardiovascular Disorders Atherosclerosis Proteinuria Cardiovascular diseases Risk factors Epidemiology |
| title | Proteinuria is independently associated with carotid atherosclerosis: a multicentric study |
| title_full | Proteinuria is independently associated with carotid atherosclerosis: a multicentric study |
| title_fullStr | Proteinuria is independently associated with carotid atherosclerosis: a multicentric study |
| title_full_unstemmed | Proteinuria is independently associated with carotid atherosclerosis: a multicentric study |
| title_short | Proteinuria is independently associated with carotid atherosclerosis: a multicentric study |
| title_sort | proteinuria is independently associated with carotid atherosclerosis a multicentric study |
| topic | Atherosclerosis Proteinuria Cardiovascular diseases Risk factors Epidemiology |
| url | https://doi.org/10.1186/s12872-021-02367-x |
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