Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatment
Abstract Physcion is an anthraquinone compound observed dominantly in medicinal herbs. This anthraquinone possesses a variety of pharmaceutically important activities and has been developed to be a widely used antifungal biopesticide. Herein, we report on the effective preparation of 3R-torosachryso...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2023-01-01
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| Series: | Bioresources and Bioprocessing |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40643-023-00625-8 |
| _version_ | 1828063891508166656 |
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| author | Zheng Zhuang Xueqing Zhong Qinghua Li Tian Liu Qing Yang Guo-Qiang Lin Qing-Li He Qunfei Zhao Wen Liu |
| author_facet | Zheng Zhuang Xueqing Zhong Qinghua Li Tian Liu Qing Yang Guo-Qiang Lin Qing-Li He Qunfei Zhao Wen Liu |
| author_sort | Zheng Zhuang |
| collection | DOAJ |
| description | Abstract Physcion is an anthraquinone compound observed dominantly in medicinal herbs. This anthraquinone possesses a variety of pharmaceutically important activities and has been developed to be a widely used antifungal biopesticide. Herein, we report on the effective preparation of 3R-torosachrysone (4), a tetrahydroanthracene precursor of physcion, in Aspergillus oryzae NSAR1 by heterologous expression of related genes mined from the phlegmacins-producing ascomycete Talaromyces sp. F08Z-0631. Conditions for converting 4 into physcion were studied and optimized, leading to the development of a concise approach for extracting high-purity physcion from the alkali-treated fermentation broth of the 4-producing A. oryzae strain. Graphical Abstract |
| first_indexed | 2024-04-10T22:50:12Z |
| format | Article |
| id | doaj.art-2e20b07b0319470bbcb28597a5980a96 |
| institution | Directory Open Access Journal |
| issn | 2197-4365 |
| language | English |
| last_indexed | 2024-04-10T22:50:12Z |
| publishDate | 2023-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bioresources and Bioprocessing |
| spelling | doaj.art-2e20b07b0319470bbcb28597a5980a962023-01-15T12:03:19ZengSpringerOpenBioresources and Bioprocessing2197-43652023-01-011011910.1186/s40643-023-00625-8Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatmentZheng Zhuang0Xueqing Zhong1Qinghua Li2Tian Liu3Qing Yang4Guo-Qiang Lin5Qing-Li He6Qunfei Zhao7Wen Liu8The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineThe Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineThe Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineSchool of Bioengineering, Dalian University of TechnologyState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural SciencesThe Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineThe Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineThe Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineState Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesAbstract Physcion is an anthraquinone compound observed dominantly in medicinal herbs. This anthraquinone possesses a variety of pharmaceutically important activities and has been developed to be a widely used antifungal biopesticide. Herein, we report on the effective preparation of 3R-torosachrysone (4), a tetrahydroanthracene precursor of physcion, in Aspergillus oryzae NSAR1 by heterologous expression of related genes mined from the phlegmacins-producing ascomycete Talaromyces sp. F08Z-0631. Conditions for converting 4 into physcion were studied and optimized, leading to the development of a concise approach for extracting high-purity physcion from the alkali-treated fermentation broth of the 4-producing A. oryzae strain. Graphical Abstracthttps://doi.org/10.1186/s40643-023-00625-8Antifungal biopesticidePhyscionMicrobial production |
| spellingShingle | Zheng Zhuang Xueqing Zhong Qinghua Li Tian Liu Qing Yang Guo-Qiang Lin Qing-Li He Qunfei Zhao Wen Liu Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatment Bioresources and Bioprocessing Antifungal biopesticide Physcion Microbial production |
| title | Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatment |
| title_full | Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatment |
| title_fullStr | Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatment |
| title_full_unstemmed | Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatment |
| title_short | Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatment |
| title_sort | production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post treatment |
| topic | Antifungal biopesticide Physcion Microbial production |
| url | https://doi.org/10.1186/s40643-023-00625-8 |
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