The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1
Objective(s): The purpose of this study was to evaluate the effect of moderate-intensity swimming exercise on learning and memory by the Morris water maze test. Changes in the expressions of cyclic AMP-response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) proteins alte...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2021-10-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | https://ijbms.mums.ac.ir/article_18754_892a94dfadfad7f529bb19c8937804d3.pdf |
| _version_ | 1818773611821924352 |
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| author | Ulker Tunca Mustafa Saygin Ozlem Ozmen Rahime Aslankoc Arzu Yalcin |
| author_facet | Ulker Tunca Mustafa Saygin Ozlem Ozmen Rahime Aslankoc Arzu Yalcin |
| author_sort | Ulker Tunca |
| collection | DOAJ |
| description | Objective(s): The purpose of this study was to evaluate the effect of moderate-intensity swimming exercise on learning and memory by the Morris water maze test. Changes in the expressions of cyclic AMP-response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) proteins alternative pathway which were activated by sirtuin-1 (SIRT-1) were investigated. Materials and Methods: The study included thirty-two male Sprague-Dawley rats (350-500 g, 11-12 and 15–16 months old). The rats were randomly divided into four groups with 8 rats in each group. The groups were designed as follows: Control-1 (11-12 months), Exercise-1 (11-12 months), Control-2 (15-16 months), Exercise-2 (15-16 months). Moderate-intensity exercise was assigned for 30 min/day, 5 days/week, for the whole training period of 8 weeks. Results: There were statistically significant differences between the groups on the third day (P=0.005) when swim speeds increased in the exercise groups. There was a statistically significant difference between Exercise 1 and Exercise 2 groups, the entries in the platform zone decreased in Exercise 2 group (P=0.026). While there were no histopathological findings observed in any group, increased SIRT-1, BNDF, and CREB expressions were seen in exercise groups compared with control groups.Conclusion: In aged rats exercising at moderate intensity, increased expression of CREB and BDNF, and SIRT-1 could improve hippocampal-dependent memory. |
| first_indexed | 2024-12-18T10:28:00Z |
| format | Article |
| id | doaj.art-2e20d486c98c48efa482a30f898e8b04 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-18T10:28:00Z |
| publishDate | 2021-10-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-2e20d486c98c48efa482a30f898e8b042022-12-21T21:10:56ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742021-10-0124101413142010.22038/ijbms.2021.58145.1292018754The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1Ulker Tunca0Mustafa Saygin1Ozlem Ozmen2Rahime Aslankoc3Arzu Yalcin4Suleyman Demirel University, Faculty of Medicine, Department of Physiology, Isparta, TurkeySuleyman Demirel University, Faculty of Medicine, Department of Physiology, Isparta, TurkeyDepartment of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, TurkeySuleyman Demirel University, Faculty of Medicine, Department of Physiology, Isparta, TurkeySuleyman Demirel University, Faculty of Medicine, Department of Physiology, Isparta, TurkeyObjective(s): The purpose of this study was to evaluate the effect of moderate-intensity swimming exercise on learning and memory by the Morris water maze test. Changes in the expressions of cyclic AMP-response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) proteins alternative pathway which were activated by sirtuin-1 (SIRT-1) were investigated. Materials and Methods: The study included thirty-two male Sprague-Dawley rats (350-500 g, 11-12 and 15–16 months old). The rats were randomly divided into four groups with 8 rats in each group. The groups were designed as follows: Control-1 (11-12 months), Exercise-1 (11-12 months), Control-2 (15-16 months), Exercise-2 (15-16 months). Moderate-intensity exercise was assigned for 30 min/day, 5 days/week, for the whole training period of 8 weeks. Results: There were statistically significant differences between the groups on the third day (P=0.005) when swim speeds increased in the exercise groups. There was a statistically significant difference between Exercise 1 and Exercise 2 groups, the entries in the platform zone decreased in Exercise 2 group (P=0.026). While there were no histopathological findings observed in any group, increased SIRT-1, BNDF, and CREB expressions were seen in exercise groups compared with control groups.Conclusion: In aged rats exercising at moderate intensity, increased expression of CREB and BDNF, and SIRT-1 could improve hippocampal-dependent memory.https://ijbms.mums.ac.ir/article_18754_892a94dfadfad7f529bb19c8937804d3.pdfbdnfcreblearning-memorysirtuin-1swimming exercise |
| spellingShingle | Ulker Tunca Mustafa Saygin Ozlem Ozmen Rahime Aslankoc Arzu Yalcin The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1 Iranian Journal of Basic Medical Sciences bdnf creb learning-memory sirtuin-1 swimming exercise |
| title | The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1 |
| title_full | The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1 |
| title_fullStr | The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1 |
| title_full_unstemmed | The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1 |
| title_short | The impact of moderate-intensity swimming exercise on learning and memory in aged rats: The role of Sirtuin-1 |
| title_sort | impact of moderate intensity swimming exercise on learning and memory in aged rats the role of sirtuin 1 |
| topic | bdnf creb learning-memory sirtuin-1 swimming exercise |
| url | https://ijbms.mums.ac.ir/article_18754_892a94dfadfad7f529bb19c8937804d3.pdf |
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