Nanoparticle-based materials in anticancer drug delivery: Current and future prospects
The past decade has witnessed a breakthrough in novel strategies to treat cancer. One of the most common cancer treatment modalities is chemotherapy which involves administering anti-cancer drugs to the body. However, these drugs can lead to undesirable side effects on healthy cells. To overcome thi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023084359 |
| _version_ | 1797429895814447104 |
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| author | Saniha Ajith Fares Almomani Abdelbary Elhissi Ghaleb A. Husseini |
| author_facet | Saniha Ajith Fares Almomani Abdelbary Elhissi Ghaleb A. Husseini |
| author_sort | Saniha Ajith |
| collection | DOAJ |
| description | The past decade has witnessed a breakthrough in novel strategies to treat cancer. One of the most common cancer treatment modalities is chemotherapy which involves administering anti-cancer drugs to the body. However, these drugs can lead to undesirable side effects on healthy cells. To overcome this challenge and improve cancer cell targeting, many novel nanocarriers have been developed to deliver drugs directly to the cancerous cells and minimize effects on the healthy tissues. The majority of the research studies conclude that using drugs encapsulated in nanocarriers is a much safer and more effective alternative than delivering the drug alone in its free form. This review provides a summary of the types of nanocarriers mainly studied for cancer drug delivery, namely: liposomes, polymeric micelles, dendrimers, magnetic nanoparticles, mesoporous nanoparticles, gold nanoparticles, carbon nanotubes and quantum dots. In this review, the synthesis, applications, advantages, disadvantages, and previous studies of these nanomaterials are discussed in detail. Furthermore, the future opportunities and possible challenges of translating these materials into clinical applications are also reported. |
| first_indexed | 2024-03-09T09:19:30Z |
| format | Article |
| id | doaj.art-2e21b1cbd5404686ae365fb6d870bd0c |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-09T09:19:30Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-2e21b1cbd5404686ae365fb6d870bd0c2023-12-02T07:01:32ZengElsevierHeliyon2405-84402023-11-01911e21227Nanoparticle-based materials in anticancer drug delivery: Current and future prospectsSaniha Ajith0Fares Almomani1Abdelbary Elhissi2Ghaleb A. Husseini3Department of Chemical Engineering, College of Engineering, Qatar University, Doha, QatarDepartment of Chemical Engineering, College of Engineering, Qatar University, Doha, Qatar; Corresponding author.College of Pharmacy, QU Health, Qatar University, Doha, QatarDepartment of Chemical Engineering, College of Engineering, American University of Sharjah, United Arab Emirates; Materials Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah, P.O. Box 26666, United Arab EmiratesThe past decade has witnessed a breakthrough in novel strategies to treat cancer. One of the most common cancer treatment modalities is chemotherapy which involves administering anti-cancer drugs to the body. However, these drugs can lead to undesirable side effects on healthy cells. To overcome this challenge and improve cancer cell targeting, many novel nanocarriers have been developed to deliver drugs directly to the cancerous cells and minimize effects on the healthy tissues. The majority of the research studies conclude that using drugs encapsulated in nanocarriers is a much safer and more effective alternative than delivering the drug alone in its free form. This review provides a summary of the types of nanocarriers mainly studied for cancer drug delivery, namely: liposomes, polymeric micelles, dendrimers, magnetic nanoparticles, mesoporous nanoparticles, gold nanoparticles, carbon nanotubes and quantum dots. In this review, the synthesis, applications, advantages, disadvantages, and previous studies of these nanomaterials are discussed in detail. Furthermore, the future opportunities and possible challenges of translating these materials into clinical applications are also reported.http://www.sciencedirect.com/science/article/pii/S2405844023084359Drug deliveryNanomaterialsCancer therapyNanocarriersNanomedicine |
| spellingShingle | Saniha Ajith Fares Almomani Abdelbary Elhissi Ghaleb A. Husseini Nanoparticle-based materials in anticancer drug delivery: Current and future prospects Heliyon Drug delivery Nanomaterials Cancer therapy Nanocarriers Nanomedicine |
| title | Nanoparticle-based materials in anticancer drug delivery: Current and future prospects |
| title_full | Nanoparticle-based materials in anticancer drug delivery: Current and future prospects |
| title_fullStr | Nanoparticle-based materials in anticancer drug delivery: Current and future prospects |
| title_full_unstemmed | Nanoparticle-based materials in anticancer drug delivery: Current and future prospects |
| title_short | Nanoparticle-based materials in anticancer drug delivery: Current and future prospects |
| title_sort | nanoparticle based materials in anticancer drug delivery current and future prospects |
| topic | Drug delivery Nanomaterials Cancer therapy Nanocarriers Nanomedicine |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023084359 |
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