CD8 + T-cell marker genes reveal different immune subtypes of oral lichen planus by integrating single-cell RNA-seq and bulk RNA-sequencing

CD8 + T-cell marker genes reveal different immune subtypes of oral lichen planus by integrating single-cell RNA-seq and bulk RNA-sequencing

Abstract Background Oral lichen planus (OLP) is a local autoimmune disease induced by T-cell dysfunction that frequently affects middle-aged or elderly people, with a higher prevalence in women. CD8 + T cells, also known as killer T cells, play an important role in the progression and persistence of...

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Bibliographic Details
Main Authors: Jinhao Zhang, Gaoge Peng, Hao Chi, Jinyan Yang, Xixi Xie, Guobin Song, Lisa Jia Tran, Zhijia Xia, Gang Tian
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Oral Health
Subjects:
Autoimmunity
OLP
CD8 + T cells
Unsupervised hierarchical clustering
Single-cell sequencing
Online Access:https://doi.org/10.1186/s12903-023-03138-0

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