Body‐Integrated, Enzyme‐Triggered Degradable, Silk‐Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment
Abstract Mechanical signals such as pressure and strain reflect important psychological and physiological states of the human body. Body‐integrated sensors, including skin‐mounted and surgically implanted ones, allow personalized health monitoring for the general population as well as patients. Howe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-07-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.201903802 |
| _version_ | 1828769885406101504 |
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| author | Shan Zhang Zhitao Zhou Junjie Zhong Zhifeng Shi Ying Mao Tiger H. Tao |
| author_facet | Shan Zhang Zhitao Zhou Junjie Zhong Zhifeng Shi Ying Mao Tiger H. Tao |
| author_sort | Shan Zhang |
| collection | DOAJ |
| description | Abstract Mechanical signals such as pressure and strain reflect important psychological and physiological states of the human body. Body‐integrated sensors, including skin‐mounted and surgically implanted ones, allow personalized health monitoring for the general population as well as patients. However, the development of such measuring devices has been hindered by the strict requirements for human‐biocompatible materials and the need for high performance sensors; most existing devices or sensors do not meet all the desired specifications. Here, a set of flexible, stretchable, wearable, implantable, and degradable mechanical sensors is reported with excellent mechanical robustness and compliance, outstanding biocompatibility, remotely‐triggered degradation, and excellent sensing performance, using a conductive silk fibroin hydrogel (CSFH). They can detect multiple mechanical signals such as pressure, strain, and bending angles. Moreover, combined with a drug‐loaded silk‐based microneedle array, sensor‐equipped devices are shown to be effective for real‐time monitoring and in situ treatment of epilepsy in a rodent model. These sensors offer potential applications in custom health monitoring wearables, and in situ treatment of chronic clinical disorders. |
| first_indexed | 2024-12-11T13:57:01Z |
| format | Article |
| id | doaj.art-2e240e30d3e047c48f4e3e5bd52773cd |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-11T13:57:01Z |
| publishDate | 2020-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-2e240e30d3e047c48f4e3e5bd52773cd2022-12-22T01:04:01ZengWileyAdvanced Science2198-38442020-07-01713n/an/a10.1002/advs.201903802Body‐Integrated, Enzyme‐Triggered Degradable, Silk‐Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ TreatmentShan Zhang0Zhitao Zhou1Junjie Zhong2Zhifeng Shi3Ying Mao4Tiger H. Tao5State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 ChinaState Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 ChinaDepartment of Neurosurgery Huashan Hospital of Fudan University Shanghai 200040 ChinaDepartment of Neurosurgery Huashan Hospital of Fudan University Shanghai 200040 ChinaDepartment of Neurosurgery Huashan Hospital of Fudan University Shanghai 200040 ChinaState Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 ChinaAbstract Mechanical signals such as pressure and strain reflect important psychological and physiological states of the human body. Body‐integrated sensors, including skin‐mounted and surgically implanted ones, allow personalized health monitoring for the general population as well as patients. However, the development of such measuring devices has been hindered by the strict requirements for human‐biocompatible materials and the need for high performance sensors; most existing devices or sensors do not meet all the desired specifications. Here, a set of flexible, stretchable, wearable, implantable, and degradable mechanical sensors is reported with excellent mechanical robustness and compliance, outstanding biocompatibility, remotely‐triggered degradation, and excellent sensing performance, using a conductive silk fibroin hydrogel (CSFH). They can detect multiple mechanical signals such as pressure, strain, and bending angles. Moreover, combined with a drug‐loaded silk‐based microneedle array, sensor‐equipped devices are shown to be effective for real‐time monitoring and in situ treatment of epilepsy in a rodent model. These sensors offer potential applications in custom health monitoring wearables, and in situ treatment of chronic clinical disorders.https://doi.org/10.1002/advs.201903802degradable sensorshealth monitoringin situ treatmentsmechanical sensorssilk hydrogels |
| spellingShingle | Shan Zhang Zhitao Zhou Junjie Zhong Zhifeng Shi Ying Mao Tiger H. Tao Body‐Integrated, Enzyme‐Triggered Degradable, Silk‐Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment Advanced Science degradable sensors health monitoring in situ treatments mechanical sensors silk hydrogels |
| title | Body‐Integrated, Enzyme‐Triggered Degradable, Silk‐Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment |
| title_full | Body‐Integrated, Enzyme‐Triggered Degradable, Silk‐Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment |
| title_fullStr | Body‐Integrated, Enzyme‐Triggered Degradable, Silk‐Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment |
| title_full_unstemmed | Body‐Integrated, Enzyme‐Triggered Degradable, Silk‐Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment |
| title_short | Body‐Integrated, Enzyme‐Triggered Degradable, Silk‐Based Mechanical Sensors for Customized Health/Fitness Monitoring and In Situ Treatment |
| title_sort | body integrated enzyme triggered degradable silk based mechanical sensors for customized health fitness monitoring and in situ treatment |
| topic | degradable sensors health monitoring in situ treatments mechanical sensors silk hydrogels |
| url | https://doi.org/10.1002/advs.201903802 |
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