The evidence for non-typeable Haemophilus influenzae as a causative agent of childhood pneumonia
Abstract Haemophilus influenzae type b (Hib) was a major cause of bacterial pneumonia in children prior to the introduction of Hib-conjugate vaccines. The widespread use of Hib-conjugate vaccines has resulted in a significant decline in the number of cases of invasive Hib disease, including bacterae...
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | Pneumonia |
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| Online Access: | http://link.springer.com/article/10.1186/s41479-017-0033-2 |
| _version_ | 1828770775936532480 |
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| author | Mary P E Slack |
| author_facet | Mary P E Slack |
| author_sort | Mary P E Slack |
| collection | DOAJ |
| description | Abstract Haemophilus influenzae type b (Hib) was a major cause of bacterial pneumonia in children prior to the introduction of Hib-conjugate vaccines. The widespread use of Hib-conjugate vaccines has resulted in a significant decline in the number of cases of invasive Hib disease, including bacteraemic pneumonia, in areas where the vaccine has been implemented. In many countries, non-typeable H. influenzae (NTHI) is now the most common cause of invasive haemophilus infection in all ages. NTHI are a recognized cause of bacteraemic and non-bacteraemic pneumonia in children and in adults. Less than 10% of cases of pediatric pneumonia are bacteraemic, and children generally do not expectorate lower respiratory tract secretions, so determining the microbial cause of a non-bacteraemic pneumonia is challenging. In this commentary the evidence that NTHI is a cause of pneumonia in children is briefly reviewed. |
| first_indexed | 2024-12-11T14:12:34Z |
| format | Article |
| id | doaj.art-2e2590ce4cfb46e1bf3726a23aecb078 |
| institution | Directory Open Access Journal |
| issn | 2200-6133 |
| language | English |
| last_indexed | 2024-12-11T14:12:34Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Pneumonia |
| spelling | doaj.art-2e2590ce4cfb46e1bf3726a23aecb0782022-12-22T01:03:20ZengBMCPneumonia2200-61332017-06-01911410.1186/s41479-017-0033-2The evidence for non-typeable Haemophilus influenzae as a causative agent of childhood pneumoniaMary P E Slack0School of Medicine, Gold Coast Campus, Griffith UniversityAbstract Haemophilus influenzae type b (Hib) was a major cause of bacterial pneumonia in children prior to the introduction of Hib-conjugate vaccines. The widespread use of Hib-conjugate vaccines has resulted in a significant decline in the number of cases of invasive Hib disease, including bacteraemic pneumonia, in areas where the vaccine has been implemented. In many countries, non-typeable H. influenzae (NTHI) is now the most common cause of invasive haemophilus infection in all ages. NTHI are a recognized cause of bacteraemic and non-bacteraemic pneumonia in children and in adults. Less than 10% of cases of pediatric pneumonia are bacteraemic, and children generally do not expectorate lower respiratory tract secretions, so determining the microbial cause of a non-bacteraemic pneumonia is challenging. In this commentary the evidence that NTHI is a cause of pneumonia in children is briefly reviewed.http://link.springer.com/article/10.1186/s41479-017-0033-2Non-typeable Haemophilus influenzaeCommunity-acquired pneumoniaChildren |
| spellingShingle | Mary P E Slack The evidence for non-typeable Haemophilus influenzae as a causative agent of childhood pneumonia Pneumonia Non-typeable Haemophilus influenzae Community-acquired pneumonia Children |
| title | The evidence for non-typeable Haemophilus influenzae as a causative agent of childhood pneumonia |
| title_full | The evidence for non-typeable Haemophilus influenzae as a causative agent of childhood pneumonia |
| title_fullStr | The evidence for non-typeable Haemophilus influenzae as a causative agent of childhood pneumonia |
| title_full_unstemmed | The evidence for non-typeable Haemophilus influenzae as a causative agent of childhood pneumonia |
| title_short | The evidence for non-typeable Haemophilus influenzae as a causative agent of childhood pneumonia |
| title_sort | evidence for non typeable haemophilus influenzae as a causative agent of childhood pneumonia |
| topic | Non-typeable Haemophilus influenzae Community-acquired pneumonia Children |
| url | http://link.springer.com/article/10.1186/s41479-017-0033-2 |
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