Sickle cells are not necessarily protective against falciparum- A case report
The relation between sickle cell disease (SCD) and malaria is captivating where sickling of the infected red blood cells (RBCs) causes premature hemolysis and parasite death. Although patients with sickle cell trait are relatively protected, malaria can often lead to marked anemia in them due to hem...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=2;spage=266;epage=268;aulast=Rasalam |
| _version_ | 1811200618713317376 |
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| author | Jess Elizabeth Rasalam Snehil Kumar K Sujith N A Fouzia Arpana Palle Dolly Daniel Sukesh Chandran Nair |
| author_facet | Jess Elizabeth Rasalam Snehil Kumar K Sujith N A Fouzia Arpana Palle Dolly Daniel Sukesh Chandran Nair |
| author_sort | Jess Elizabeth Rasalam |
| collection | DOAJ |
| description | The relation between sickle cell disease (SCD) and malaria is captivating where sickling of the infected red blood cells (RBCs) causes premature hemolysis and parasite death. Although patients with sickle cell trait are relatively protected, malaria can often lead to marked anemia in them due to hemolysis. We report an unusual case of a child with homozygous SCD presenting with falciparum malaria and had hyper parasitemia and severe anemia which completely resolved following treatment. Clinical suspicion in our case arose considering the endemic nature of malaria in our country. The two overlapping injuries to spleen reduced the clearance of parasites by the spleen as evidenced by high parasite load. Our case report reinforces malaria as a cause of clinical worsening of SCD and highlights the importance of a multifactorial approach in the management of worsening anemia in SCD. |
| first_indexed | 2024-04-12T02:06:37Z |
| format | Article |
| id | doaj.art-2e26e88ffd8549e0824b4df15d15972c |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-04-12T02:06:37Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-2e26e88ffd8549e0824b4df15d15972c2022-12-22T03:52:30ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652022-01-0116226626810.4103/ajts.ajts_122_21Sickle cells are not necessarily protective against falciparum- A case reportJess Elizabeth RasalamSnehil KumarK SujithN A FouziaArpana PalleDolly DanielSukesh Chandran NairThe relation between sickle cell disease (SCD) and malaria is captivating where sickling of the infected red blood cells (RBCs) causes premature hemolysis and parasite death. Although patients with sickle cell trait are relatively protected, malaria can often lead to marked anemia in them due to hemolysis. We report an unusual case of a child with homozygous SCD presenting with falciparum malaria and had hyper parasitemia and severe anemia which completely resolved following treatment. Clinical suspicion in our case arose considering the endemic nature of malaria in our country. The two overlapping injuries to spleen reduced the clearance of parasites by the spleen as evidenced by high parasite load. Our case report reinforces malaria as a cause of clinical worsening of SCD and highlights the importance of a multifactorial approach in the management of worsening anemia in SCD.http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=2;spage=266;epage=268;aulast=Rasalamhemolysismalariasickle cell diseases |
| spellingShingle | Jess Elizabeth Rasalam Snehil Kumar K Sujith N A Fouzia Arpana Palle Dolly Daniel Sukesh Chandran Nair Sickle cells are not necessarily protective against falciparum- A case report Asian Journal of Transfusion Science hemolysis malaria sickle cell diseases |
| title | Sickle cells are not necessarily protective against falciparum- A case report |
| title_full | Sickle cells are not necessarily protective against falciparum- A case report |
| title_fullStr | Sickle cells are not necessarily protective against falciparum- A case report |
| title_full_unstemmed | Sickle cells are not necessarily protective against falciparum- A case report |
| title_short | Sickle cells are not necessarily protective against falciparum- A case report |
| title_sort | sickle cells are not necessarily protective against falciparum a case report |
| topic | hemolysis malaria sickle cell diseases |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=2;spage=266;epage=268;aulast=Rasalam |
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