In dogs undergoing elective procedures is medetomidine superior to acepromazine when used as a premedication?
PICO question In dogs undergoing elective procedures does the use of medetomidine during premedication result in an increase in anaesthetic complication rates, when compared to acepromazine? Clinical bottom line Category of research question Treatment The number and type of study...
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| Format: | Article |
| Language: | English |
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RCVS Knowledge
2020-12-01
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| Series: | Veterinary Evidence |
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| Online Access: | https://veterinaryevidence.org/index.php/ve/article/view/318 |
| _version_ | 1818600854199992320 |
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| author | Rebecca Littlehales |
| author_facet | Rebecca Littlehales |
| author_sort | Rebecca Littlehales |
| collection | DOAJ |
| description | PICO question
In dogs undergoing elective procedures does the use of medetomidine during premedication result in an increase in anaesthetic complication rates, when compared to acepromazine?
Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
Four papers were critically reviewed, all of which were randomised controlled trials
Strength of evidence
Strong
Outcomes reported
There were some statistically significant differences between using medetomidine and acepromazine as premedications in the outcomes measured, but as the clinical parameters including blood pressure were still within acceptable clinical limits, the clinical benefits of these findings remain undetermined. There is also evidence to suggest that patients premedicated with medetomidine have less of a perioperative stress response than those receiving acepromazine, but in addition may have increased risk of cardiac conduction disturbances, but the clinical importance of these findings is also unknown
Conclusion
The overall findings showed that either drug can be used as a suitable premedication, but the differences in pain score postoperatively shown in one small study mean that due to its poor analgesic properties it is recommended when using acepromazine instead of medetomidine, that additional analgesia should be given to reduce postoperative pain for better animal welfare
How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care. |
| first_indexed | 2024-12-16T12:42:06Z |
| format | Article |
| id | doaj.art-2e29dddb4424402eaf7fea8b9fe72782 |
| institution | Directory Open Access Journal |
| issn | 2396-9776 |
| language | English |
| last_indexed | 2024-12-16T12:42:06Z |
| publishDate | 2020-12-01 |
| publisher | RCVS Knowledge |
| record_format | Article |
| series | Veterinary Evidence |
| spelling | doaj.art-2e29dddb4424402eaf7fea8b9fe727822022-12-21T22:31:23ZengRCVS KnowledgeVeterinary Evidence2396-97762020-12-015410.18849/ve.v5i4.318318In dogs undergoing elective procedures is medetomidine superior to acepromazine when used as a premedication?Rebecca Littlehales0University of LiverpoolPICO question In dogs undergoing elective procedures does the use of medetomidine during premedication result in an increase in anaesthetic complication rates, when compared to acepromazine? Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Four papers were critically reviewed, all of which were randomised controlled trials Strength of evidence Strong Outcomes reported There were some statistically significant differences between using medetomidine and acepromazine as premedications in the outcomes measured, but as the clinical parameters including blood pressure were still within acceptable clinical limits, the clinical benefits of these findings remain undetermined. There is also evidence to suggest that patients premedicated with medetomidine have less of a perioperative stress response than those receiving acepromazine, but in addition may have increased risk of cardiac conduction disturbances, but the clinical importance of these findings is also unknown Conclusion The overall findings showed that either drug can be used as a suitable premedication, but the differences in pain score postoperatively shown in one small study mean that due to its poor analgesic properties it is recommended when using acepromazine instead of medetomidine, that additional analgesia should be given to reduce postoperative pain for better animal welfare How to apply this evidence in practice The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources. Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.https://veterinaryevidence.org/index.php/ve/article/view/318caninepremedicationacepromazinemedetomidineanaesthetic complications |
| spellingShingle | Rebecca Littlehales In dogs undergoing elective procedures is medetomidine superior to acepromazine when used as a premedication? Veterinary Evidence canine premedication acepromazine medetomidine anaesthetic complications |
| title | In dogs undergoing elective procedures is medetomidine superior to acepromazine when used as a premedication? |
| title_full | In dogs undergoing elective procedures is medetomidine superior to acepromazine when used as a premedication? |
| title_fullStr | In dogs undergoing elective procedures is medetomidine superior to acepromazine when used as a premedication? |
| title_full_unstemmed | In dogs undergoing elective procedures is medetomidine superior to acepromazine when used as a premedication? |
| title_short | In dogs undergoing elective procedures is medetomidine superior to acepromazine when used as a premedication? |
| title_sort | in dogs undergoing elective procedures is medetomidine superior to acepromazine when used as a premedication |
| topic | canine premedication acepromazine medetomidine anaesthetic complications |
| url | https://veterinaryevidence.org/index.php/ve/article/view/318 |
| work_keys_str_mv | AT rebeccalittlehales indogsundergoingelectiveproceduresismedetomidinesuperiortoacepromazinewhenusedasapremedication |