Outbreak of respiratory syncytial virus subtype ON1 among children during COVID-19 pandemic in Southern Taiwan
Background: The regional respiratory syncytial virus (RSV) outbreak in southern Taiwan in late 2020 followed the surge of RSV cases in the national surveillance data and displayed distinct clinical features. This study investigated RSV epidemiology in the most recent five years and compared the clin...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Journal of Microbiology, Immunology and Infection |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S168411822200144X |
| _version_ | 1811183655055261696 |
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| author | Ting-Yu Lin Hsin Chi Cheng-Yen Kuo Huey-Pin Tsai Jen-Ren Wang Ching-Chuan Liu Ching-Fen Shen |
| author_facet | Ting-Yu Lin Hsin Chi Cheng-Yen Kuo Huey-Pin Tsai Jen-Ren Wang Ching-Chuan Liu Ching-Fen Shen |
| author_sort | Ting-Yu Lin |
| collection | DOAJ |
| description | Background: The regional respiratory syncytial virus (RSV) outbreak in southern Taiwan in late 2020 followed the surge of RSV cases in the national surveillance data and displayed distinct clinical features. This study investigated RSV epidemiology in the most recent five years and compared the clinical manifestations of this outbreak with non-outbreak period. Methods: Medical records of RSV-infected children at the National Cheng Kung University Hospital from January 2016 to December 2020 were retrospectively retrieved from hospital-based electronic medical database. Cases of RSV infection were identified by RSV antigen positive and/or RSV isolated from respiratory specimens. The demographic, clinical presentations, and laboratory data were recorded. The RSV isolates in 2020 was sequenced for phylogenetic analysis. Results: Overall, 442 RSV-infected cases were retrieved and 42.1% (186 cases) clustered in late 2020. The 2020 outbreak started in September, peaked in November, and lasted for 3 months. 2020 RSV-infected children were older (2.3 ± 2.2 years vs. 1.0 ± 1.0 years), more likely to be diagnosed with bronchopneumonia (57.5% vs. 31.6%), but also had a lower hospitalization rate, shorter hospital stay, less oxygen use, and less respiratory distress than those in 2016–2019 (all p value < 0.05). The RSV isolates in 2020 belonged to RSV-A subtype ON1 but were phylogenetically distinct from the ON1 strains prevalent in Taiwan previously. Conclusion: The 2020 RSV outbreak was led by the novel RSV-A subtype ON1 variant with clinical manifestations distinct from previous years. Continuous surveillance of new emerging variants of respiratory viruses in the post-pandemic era is warranted. |
| first_indexed | 2024-04-11T09:49:25Z |
| format | Article |
| id | doaj.art-2e2a975bb2e045adbe0721c0b2b71619 |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-04-11T09:49:25Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-2e2a975bb2e045adbe0721c0b2b716192022-12-22T04:30:50ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822022-12-0155611681179Outbreak of respiratory syncytial virus subtype ON1 among children during COVID-19 pandemic in Southern TaiwanTing-Yu Lin0Hsin Chi1Cheng-Yen Kuo2Huey-Pin Tsai3Jen-Ren Wang4Ching-Chuan Liu5Ching-Fen Shen6Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Medicine, MacKay Medicine College, New Taipei, Taiwan; Department of Pediatrics, MacKay Children's Hospital and MacKay Memorial Hospital, Taipei, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan; Corresponding author. Division of Pediatric Infectious Diseases, Department of Pediatrics, National Cheng Kung University Hospital, No.138, Sheng-Li Road, North District, Tainan City, 70403, Taiwan. Fax: +886 6 2753083.Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Corresponding author. Division of Pediatric Infectious Diseases, Department of Pediatrics, National Cheng Kung University Hospital, No.138, Sheng-Li Road, North District, Tainan City, 70403, Taiwan. Fax: +886 6 2758781.Background: The regional respiratory syncytial virus (RSV) outbreak in southern Taiwan in late 2020 followed the surge of RSV cases in the national surveillance data and displayed distinct clinical features. This study investigated RSV epidemiology in the most recent five years and compared the clinical manifestations of this outbreak with non-outbreak period. Methods: Medical records of RSV-infected children at the National Cheng Kung University Hospital from January 2016 to December 2020 were retrospectively retrieved from hospital-based electronic medical database. Cases of RSV infection were identified by RSV antigen positive and/or RSV isolated from respiratory specimens. The demographic, clinical presentations, and laboratory data were recorded. The RSV isolates in 2020 was sequenced for phylogenetic analysis. Results: Overall, 442 RSV-infected cases were retrieved and 42.1% (186 cases) clustered in late 2020. The 2020 outbreak started in September, peaked in November, and lasted for 3 months. 2020 RSV-infected children were older (2.3 ± 2.2 years vs. 1.0 ± 1.0 years), more likely to be diagnosed with bronchopneumonia (57.5% vs. 31.6%), but also had a lower hospitalization rate, shorter hospital stay, less oxygen use, and less respiratory distress than those in 2016–2019 (all p value < 0.05). The RSV isolates in 2020 belonged to RSV-A subtype ON1 but were phylogenetically distinct from the ON1 strains prevalent in Taiwan previously. Conclusion: The 2020 RSV outbreak was led by the novel RSV-A subtype ON1 variant with clinical manifestations distinct from previous years. Continuous surveillance of new emerging variants of respiratory viruses in the post-pandemic era is warranted.http://www.sciencedirect.com/science/article/pii/S168411822200144XRespiratory syncytial virusRSV-A subtype ON1Novel ON1 variantsBronchiolitisBronchopneumoniaCOVID-19 pandemic |
| spellingShingle | Ting-Yu Lin Hsin Chi Cheng-Yen Kuo Huey-Pin Tsai Jen-Ren Wang Ching-Chuan Liu Ching-Fen Shen Outbreak of respiratory syncytial virus subtype ON1 among children during COVID-19 pandemic in Southern Taiwan Journal of Microbiology, Immunology and Infection Respiratory syncytial virus RSV-A subtype ON1 Novel ON1 variants Bronchiolitis Bronchopneumonia COVID-19 pandemic |
| title | Outbreak of respiratory syncytial virus subtype ON1 among children during COVID-19 pandemic in Southern Taiwan |
| title_full | Outbreak of respiratory syncytial virus subtype ON1 among children during COVID-19 pandemic in Southern Taiwan |
| title_fullStr | Outbreak of respiratory syncytial virus subtype ON1 among children during COVID-19 pandemic in Southern Taiwan |
| title_full_unstemmed | Outbreak of respiratory syncytial virus subtype ON1 among children during COVID-19 pandemic in Southern Taiwan |
| title_short | Outbreak of respiratory syncytial virus subtype ON1 among children during COVID-19 pandemic in Southern Taiwan |
| title_sort | outbreak of respiratory syncytial virus subtype on1 among children during covid 19 pandemic in southern taiwan |
| topic | Respiratory syncytial virus RSV-A subtype ON1 Novel ON1 variants Bronchiolitis Bronchopneumonia COVID-19 pandemic |
| url | http://www.sciencedirect.com/science/article/pii/S168411822200144X |
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