Women With Osteoarthritis Are at Increased Risk of Ischemic Stroke: A Population-Based Cohort Study
Background: Osteoarthritis (OA) is more prevalent in women with age. Comorbidities are prevalent in OA patients. In this study, we conducted a follow-up study to evaluate whether women with OA are at an increased risk of ischemic stroke using insurance claims data of Taiwan. Methods: We identified 1...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Japan Epidemiological Association
2021-12-01
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| Series: | Journal of Epidemiology |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jea/31/12/31_JE20200042/_pdf |
| _version_ | 1819199351240523776 |
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| author | Chung-Hsin Yeh Wei-Lun Chang Po-Chi Chan Chih-Hsin Mou Ko-Shih Chang Chung Y. Hsu Shiow-Luan Tsay Min-Tein Tsai Min-Hsien Hsu Fung-Chang Sung |
| author_facet | Chung-Hsin Yeh Wei-Lun Chang Po-Chi Chan Chih-Hsin Mou Ko-Shih Chang Chung Y. Hsu Shiow-Luan Tsay Min-Tein Tsai Min-Hsien Hsu Fung-Chang Sung |
| author_sort | Chung-Hsin Yeh |
| collection | DOAJ |
| description | Background: Osteoarthritis (OA) is more prevalent in women with age. Comorbidities are prevalent in OA patients. In this study, we conducted a follow-up study to evaluate whether women with OA are at an increased risk of ischemic stroke using insurance claims data of Taiwan. Methods: We identified 13,520 women with OA aged 20–99 newly diagnosed in 2000–2006 and 27,033 women without OA for comparison, frequency matched by age and diagnosis date. Women with baseline history of hypertension and other disorders associated with stroke were excluded for this study. Incident ischemic stroke was assessed by the end of 2013. A nested case-control analysis was used to identify factors associated with the stroke in the OA cohort. Results: The incidence rate of ischemic stroke in the OA cohort was 1.5-fold greater than that in comparisons (1.93 versus 1.26 per 1,000 person-years), with an adjusted hazard ratio of 1.34 (95% confidence interval [CI], 1.09–1.66). The nested case-control analysis showed that stroke cases were twice as likely to develop hypertension during the follow-up period than controls without stroke. The ischemic stroke risk was significantly associated with hypertension (odds ratio [OR] 1.84; 95% CI, 1.37–2.46) and atrial fibrillation (OR 2.25; 95% CI, 1.24–4.09). Ischemic stroke was not associated with the use of non-steroidal anti-inflammatory drugs or aspirin. Conclusion: Women with OA are at an elevated risk of ischemic stroke. A close monitoring of hypertension, atrial fibrillation, and other stroke related comorbidities is required for stroke prevention for OA patients. |
| first_indexed | 2024-12-23T03:14:57Z |
| format | Article |
| id | doaj.art-2e2b69bac83c4722ac3b355eb6a0836d |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-12-23T03:14:57Z |
| publishDate | 2021-12-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-2e2b69bac83c4722ac3b355eb6a0836d2022-12-21T18:02:07ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922021-12-01311262863410.2188/jea.JE20200042Women With Osteoarthritis Are at Increased Risk of Ischemic Stroke: A Population-Based Cohort StudyChung-Hsin Yeh0Wei-Lun Chang1Po-Chi Chan2Chih-Hsin Mou3Ko-Shih Chang4Chung Y. Hsu5Shiow-Luan Tsay6Min-Tein Tsai7Min-Hsien Hsu8Fung-Chang Sung9Department of Nursing, College of Nursing and Health Sciences, Da-Yeh University, Changhua, TaiwanDepartment of Neurology, Show Chwan Memorial Hospital, Changhua, TaiwanDepartment of Neurology, Show Chwan Memorial Hospital, Changhua, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung, TaiwanDepartment of Cardiology, Yuan Rung Hospital, Changhua, TaiwanGraduate Institute of Clinical Medical Science, China Medical University, Taichung, TaiwanDepartment of Nursing, College of Nursing and Health Sciences, Da-Yeh University, Changhua, TaiwanDepartment of Neurology, Yuan Sheng Hospital, Changhua, TaiwanDepartment of Neurology, Show Chwan Memorial Hospital, Changhua, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung, TaiwanBackground: Osteoarthritis (OA) is more prevalent in women with age. Comorbidities are prevalent in OA patients. In this study, we conducted a follow-up study to evaluate whether women with OA are at an increased risk of ischemic stroke using insurance claims data of Taiwan. Methods: We identified 13,520 women with OA aged 20–99 newly diagnosed in 2000–2006 and 27,033 women without OA for comparison, frequency matched by age and diagnosis date. Women with baseline history of hypertension and other disorders associated with stroke were excluded for this study. Incident ischemic stroke was assessed by the end of 2013. A nested case-control analysis was used to identify factors associated with the stroke in the OA cohort. Results: The incidence rate of ischemic stroke in the OA cohort was 1.5-fold greater than that in comparisons (1.93 versus 1.26 per 1,000 person-years), with an adjusted hazard ratio of 1.34 (95% confidence interval [CI], 1.09–1.66). The nested case-control analysis showed that stroke cases were twice as likely to develop hypertension during the follow-up period than controls without stroke. The ischemic stroke risk was significantly associated with hypertension (odds ratio [OR] 1.84; 95% CI, 1.37–2.46) and atrial fibrillation (OR 2.25; 95% CI, 1.24–4.09). Ischemic stroke was not associated with the use of non-steroidal anti-inflammatory drugs or aspirin. Conclusion: Women with OA are at an elevated risk of ischemic stroke. A close monitoring of hypertension, atrial fibrillation, and other stroke related comorbidities is required for stroke prevention for OA patients.https://www.jstage.jst.go.jp/article/jea/31/12/31_JE20200042/_pdfosteoarthritisischemic strokehypertensionnon-steroid anti-inflammatory drugsaspirin |
| spellingShingle | Chung-Hsin Yeh Wei-Lun Chang Po-Chi Chan Chih-Hsin Mou Ko-Shih Chang Chung Y. Hsu Shiow-Luan Tsay Min-Tein Tsai Min-Hsien Hsu Fung-Chang Sung Women With Osteoarthritis Are at Increased Risk of Ischemic Stroke: A Population-Based Cohort Study Journal of Epidemiology osteoarthritis ischemic stroke hypertension non-steroid anti-inflammatory drugs aspirin |
| title | Women With Osteoarthritis Are at Increased Risk of Ischemic Stroke: A Population-Based Cohort Study |
| title_full | Women With Osteoarthritis Are at Increased Risk of Ischemic Stroke: A Population-Based Cohort Study |
| title_fullStr | Women With Osteoarthritis Are at Increased Risk of Ischemic Stroke: A Population-Based Cohort Study |
| title_full_unstemmed | Women With Osteoarthritis Are at Increased Risk of Ischemic Stroke: A Population-Based Cohort Study |
| title_short | Women With Osteoarthritis Are at Increased Risk of Ischemic Stroke: A Population-Based Cohort Study |
| title_sort | women with osteoarthritis are at increased risk of ischemic stroke a population based cohort study |
| topic | osteoarthritis ischemic stroke hypertension non-steroid anti-inflammatory drugs aspirin |
| url | https://www.jstage.jst.go.jp/article/jea/31/12/31_JE20200042/_pdf |
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