Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar
Sugars that contain glucose, such as sucrose, are generally preferred to artificial sweeteners owing to their post-ingestive rewarding effect, which elevates striatal dopamine (DA) release. While the post-ingestive rewarding effect, which artificial sweeteners do not have, signals the nutrient value...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2013-12-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/01462 |
| _version_ | 1811235837376987136 |
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| author | Ana I Domingos Aylesse Sordillo Marcelo O Dietrich Zhong-Wu Liu Luis A Tellez Jake Vaynshteyn Jozelia G Ferreira Mats I Ekstrand Tamas L Horvath Ivan E de Araujo Jeffrey M Friedman |
| author_facet | Ana I Domingos Aylesse Sordillo Marcelo O Dietrich Zhong-Wu Liu Luis A Tellez Jake Vaynshteyn Jozelia G Ferreira Mats I Ekstrand Tamas L Horvath Ivan E de Araujo Jeffrey M Friedman |
| author_sort | Ana I Domingos |
| collection | DOAJ |
| description | Sugars that contain glucose, such as sucrose, are generally preferred to artificial sweeteners owing to their post-ingestive rewarding effect, which elevates striatal dopamine (DA) release. While the post-ingestive rewarding effect, which artificial sweeteners do not have, signals the nutrient value of sugar and influences food preference, the neural circuitry that mediates the rewarding effect of glucose is unknown. In this study, we show that optogenetic activation of melanin-concentrating hormone (MCH) neurons during intake of the artificial sweetener sucralose increases striatal dopamine levels and inverts the normal preference for sucrose vs sucralose. Conversely, animals with ablation of MCH neurons no longer prefer sucrose to sucralose and show reduced striatal DA release upon sucrose ingestion. We further show that MCH neurons project to reward areas and are required for the post-ingestive rewarding effect of sucrose in sweet-blind Trpm5−/− mice. These studies identify an essential component of the neural pathways linking nutrient sensing and food reward. |
| first_indexed | 2024-04-12T11:58:50Z |
| format | Article |
| id | doaj.art-2e2c255927d44e7290c9d1cd1cba0781 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T11:58:50Z |
| publishDate | 2013-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-2e2c255927d44e7290c9d1cd1cba07812022-12-22T03:33:55ZengeLife Sciences Publications LtdeLife2050-084X2013-12-01210.7554/eLife.01462Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugarAna I Domingos0Aylesse Sordillo1Marcelo O Dietrich2Zhong-Wu Liu3Luis A Tellez4Jake Vaynshteyn5Jozelia G Ferreira6Mats I Ekstrand7Tamas L Horvath8Ivan E de Araujo9Jeffrey M Friedman10Laboratory of Molecular Genetics, The Rockefeller University, New York, United StatesLaboratory of Molecular Genetics, The Rockefeller University, New York, United StatesSection of Comparative Medicine, Yale University, New Haven, United States; Department of Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, BrazilSection of Comparative Medicine, Yale University, New Haven, United StatesFeeding Laboratory, The JB Pierce Laboratory, New Haven, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, United StatesDepartment of Neuroscience, Albert Einstein College of Medicine, New York, United StatesFeeding Laboratory, The JB Pierce Laboratory, New Haven, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, United StatesLaboratory of Molecular Genetics, The Rockefeller University, New York, United StatesSection of Comparative Medicine, Yale University, New Haven, United StatesFeeding Laboratory, The JB Pierce Laboratory, New Haven, United States; Department of Psychiatry, Yale University School of Medicine, New Haven, United StatesLaboratory of Molecular Genetics, The Rockefeller University, New York, United States; Howard Hughes Medical Institute, The Rockefeller University, New York, United StatesSugars that contain glucose, such as sucrose, are generally preferred to artificial sweeteners owing to their post-ingestive rewarding effect, which elevates striatal dopamine (DA) release. While the post-ingestive rewarding effect, which artificial sweeteners do not have, signals the nutrient value of sugar and influences food preference, the neural circuitry that mediates the rewarding effect of glucose is unknown. In this study, we show that optogenetic activation of melanin-concentrating hormone (MCH) neurons during intake of the artificial sweetener sucralose increases striatal dopamine levels and inverts the normal preference for sucrose vs sucralose. Conversely, animals with ablation of MCH neurons no longer prefer sucrose to sucralose and show reduced striatal DA release upon sucrose ingestion. We further show that MCH neurons project to reward areas and are required for the post-ingestive rewarding effect of sucrose in sweet-blind Trpm5−/− mice. These studies identify an essential component of the neural pathways linking nutrient sensing and food reward.https://elifesciences.org/articles/01462obesitymetabolismnutrientfeeding behavioroptogeneticsneuronal circuit |
| spellingShingle | Ana I Domingos Aylesse Sordillo Marcelo O Dietrich Zhong-Wu Liu Luis A Tellez Jake Vaynshteyn Jozelia G Ferreira Mats I Ekstrand Tamas L Horvath Ivan E de Araujo Jeffrey M Friedman Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar eLife obesity metabolism nutrient feeding behavior optogenetics neuronal circuit |
| title | Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar |
| title_full | Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar |
| title_fullStr | Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar |
| title_full_unstemmed | Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar |
| title_short | Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar |
| title_sort | hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar |
| topic | obesity metabolism nutrient feeding behavior optogenetics neuronal circuit |
| url | https://elifesciences.org/articles/01462 |
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