Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation Recommendations
Efficient and resilient techniques for handling samples are essential for detecting pharmaceutical compounds in the environment. This study explores a method for preserving water samples during transport before quantitative analysis. The study investigates the stability of 17α-ethynylestradiol (EE2)...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2023/5526429 |
| _version_ | 1797648559440396288 |
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| author | Nuning Vita Hidayati Laurence Asia Stephanie Lebarillier Ita Widowati Agus Sabdono Anne Piram Rizqi Rizaldi Hidayat Dina Fitriyah Indra Putra Almanar Pierre Doumenq Agung Dhamar Syakti |
| author_facet | Nuning Vita Hidayati Laurence Asia Stephanie Lebarillier Ita Widowati Agus Sabdono Anne Piram Rizqi Rizaldi Hidayat Dina Fitriyah Indra Putra Almanar Pierre Doumenq Agung Dhamar Syakti |
| author_sort | Nuning Vita Hidayati |
| collection | DOAJ |
| description | Efficient and resilient techniques for handling samples are essential for detecting pharmaceutical compounds in the environment. This study explores a method for preserving water samples during transport before quantitative analysis. The study investigates the stability of 17α-ethynylestradiol (EE2), acetaminophen (ACM), oxytetracycline (OTC), sulfamethoxazole (SMX), and trimethoprim (TMP) after preconcentration within solid-phase extraction (SPE) cartridges. Through various experiments involving different holding times and storage temperatures, it was determined that four pharmaceutical compounds remained stable when stored for a month at 4°C and for six months when stored at −18°C in darkness. Storing these compounds in SPE cartridges at −18°C seemed effective in preserving them for extended periods. In addition, ACM, TMP, OTC, EE2, and SMX remained stable for three days at room temperature. These findings establish guidelines for appropriate storage and handling practices of pharmaceutical compounds preconcentrated from aqueous environmental samples using SPE. |
| first_indexed | 2024-03-11T15:33:53Z |
| format | Article |
| id | doaj.art-2e2d4ae5ebd745a39057aacc85a27a32 |
| institution | Directory Open Access Journal |
| issn | 2090-8873 |
| language | English |
| last_indexed | 2024-03-11T15:33:53Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj.art-2e2d4ae5ebd745a39057aacc85a27a322023-10-27T00:00:03ZengHindawi LimitedJournal of Analytical Methods in Chemistry2090-88732023-01-01202310.1155/2023/5526429Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation RecommendationsNuning Vita Hidayati0Laurence Asia1Stephanie Lebarillier2Ita Widowati3Agus Sabdono4Anne Piram5Rizqi Rizaldi Hidayat6Dina Fitriyah7Indra Putra Almanar8Pierre Doumenq9Agung Dhamar Syakti10Fisheries and Marine Sciences FacultyAix Marseille UniversityAix Marseille UniversityFaculty of Fisheries and Marine SciencesFaculty of Fisheries and Marine SciencesAix Marseille UniversityFisheries and Marine Sciences FacultyMaritime Technique and Technology FacultyMaritime Technique and Technology FacultyAix Marseille UniversityCenter for Maritime Biosciences StudiesEfficient and resilient techniques for handling samples are essential for detecting pharmaceutical compounds in the environment. This study explores a method for preserving water samples during transport before quantitative analysis. The study investigates the stability of 17α-ethynylestradiol (EE2), acetaminophen (ACM), oxytetracycline (OTC), sulfamethoxazole (SMX), and trimethoprim (TMP) after preconcentration within solid-phase extraction (SPE) cartridges. Through various experiments involving different holding times and storage temperatures, it was determined that four pharmaceutical compounds remained stable when stored for a month at 4°C and for six months when stored at −18°C in darkness. Storing these compounds in SPE cartridges at −18°C seemed effective in preserving them for extended periods. In addition, ACM, TMP, OTC, EE2, and SMX remained stable for three days at room temperature. These findings establish guidelines for appropriate storage and handling practices of pharmaceutical compounds preconcentrated from aqueous environmental samples using SPE.http://dx.doi.org/10.1155/2023/5526429 |
| spellingShingle | Nuning Vita Hidayati Laurence Asia Stephanie Lebarillier Ita Widowati Agus Sabdono Anne Piram Rizqi Rizaldi Hidayat Dina Fitriyah Indra Putra Almanar Pierre Doumenq Agung Dhamar Syakti Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation Recommendations Journal of Analytical Methods in Chemistry |
| title | Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation Recommendations |
| title_full | Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation Recommendations |
| title_fullStr | Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation Recommendations |
| title_full_unstemmed | Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation Recommendations |
| title_short | Environmental Sample Stability for Pharmaceutical Compound Analysis: Handling and Preservation Recommendations |
| title_sort | environmental sample stability for pharmaceutical compound analysis handling and preservation recommendations |
| url | http://dx.doi.org/10.1155/2023/5526429 |
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