Peripheral blood-derived monocytes show neuronal properties and integration in immune-deficient rd1 mouse model upon phenotypic differentiation and induction with retinal growth factors

Peripheral blood-derived monocytes show neuronal properties and integration in immune-deficient rd1 mouse model upon phenotypic differentiation and induction with retinal growth factors

Abstract Background Cell therapy is one of the most promising therapeutic interventions for retinitis pigmentosa. In the current study, we aimed to assess if peripheral blood-derived monocytes which are highly abundant and accessible could be utilized as a potential candidate for phenotypic differen...

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Main Authors: Alaknanda Mishra, K. Varsha Mohan, Perumal Nagarajan, Srikanth Iyer, Ashwani Kesarwani, Madhu Nath, Laxmi Moksha, Jashdeep Bhattacharjee, Barun Das, Kshama Jain, Parul Sahu, Prakriti Sinha, T. Velapandian, Pramod Upadhyay
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Stem Cell Research & Therapy
Subjects:
Retinitis pigmentosa
Human peripheral blood monocytes
Retinal neuron-like cells
Visual activity
rd1 mouse model
Online Access:http://link.springer.com/article/10.1186/s13287-020-01925-y

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