Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China
Abstract Background Cardiovascular disease has become the leading cause of death worldwide, but there is a lack of data on whether cardiovascular health (CVH) is associated with elderly mortality in China. We investigated the relationship between the ideal CVH score of Chinese elderly and the all-ca...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-023-04093-9 |
| _version_ | 1797778687122210816 |
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| author | Shimin Chen Haowei Li Shengshu Wang Shanshan Yang Shaohua Liu Yang Song Xuehang Li Rongrong Li Jianhua Wang Miao Liu Yao He |
| author_facet | Shimin Chen Haowei Li Shengshu Wang Shanshan Yang Shaohua Liu Yang Song Xuehang Li Rongrong Li Jianhua Wang Miao Liu Yao He |
| author_sort | Shimin Chen |
| collection | DOAJ |
| description | Abstract Background Cardiovascular disease has become the leading cause of death worldwide, but there is a lack of data on whether cardiovascular health (CVH) is associated with elderly mortality in China. We investigated the relationship between the ideal CVH score of Chinese elderly and the all-cause mortality. Methods The Beijing Elderly Comprehensive Health Cohort Study included a total of 4,499 participants aged 60 years and above. The CVH metric was calculated at baseline and had a score ranging from 0 to 12. The relationship of CVH metrics with all-cause mortality was investigated using Cox proportional hazard regression analysis. The robustness of results was tested using subgroup and sensitivity analysis. Results The median CVH score among participants was 8.00 (2.00), with only 8.0% scoring 11–12 points. 667 deaths were observed during an average follow-up time of 8.2 years. Participants with a CVH score of 11–12 had a decreased risk of all-cause mortality when compared to those with a CVH score of 0–4(HR = 0.584, 95% CI: 0.373–0.913). Participants had a 7.5% lower risk of all-cause death with each unit higher CVH score (HR = 0.925, 95%CI: 0.885–0.967) with a linearly decreasing trend (P nonlinear = 0.575). The relationships were greater in younger elderly people and stroke patients (P interaction = 0.011 and 0.037. respectively). The consistency of significant trends in sensitivity analysis shows the robustness of association (P trend < 0.001). Conclusions Among the Chinese elderly, there was a linear relationship between improving CVH scores and a lower risk of all-cause mortality. Because of the enormous benefits brought by one point, strategies are essential for improving cardiovascular health attainment. Trial registration This study was registered at China Clinical Trial Registration Center (ChiCTR2100049866). |
| first_indexed | 2024-03-12T23:21:02Z |
| format | Article |
| id | doaj.art-2e2fb2aff25b434e9051b00056eb3931 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-03-12T23:21:02Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-2e2fb2aff25b434e9051b00056eb39312023-07-16T11:27:20ZengBMCBMC Geriatrics1471-23182023-07-0123111310.1186/s12877-023-04093-9Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in ChinaShimin Chen0Haowei Li1Shengshu Wang2Shanshan Yang3Shaohua Liu4Yang Song5Xuehang Li6Rongrong Li7Jianhua Wang8Miao Liu9Yao He10Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Second Medical Center of Chinese PLA General Hospital & Chinese PLA Medical SchoolInstitute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Second Medical Center of Chinese PLA General Hospital & Chinese PLA Medical SchoolInstitute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Second Medical Center of Chinese PLA General Hospital & Chinese PLA Medical SchoolDepartment of Disease Prevention and Control, First Medical Center, Chinese PLA General Hospital & Chinese PLA Medical SchoolInstitute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Second Medical Center of Chinese PLA General Hospital & Chinese PLA Medical SchoolInstitute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Second Medical Center of Chinese PLA General Hospital & Chinese PLA Medical SchoolInstitute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Second Medical Center of Chinese PLA General Hospital & Chinese PLA Medical SchoolInstitute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Second Medical Center of Chinese PLA General Hospital & Chinese PLA Medical SchoolInstitute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Second Medical Center of Chinese PLA General Hospital & Chinese PLA Medical SchoolDepartment of Statistics and Epidemiology, Graduate School, Chinese PLA General Hospital & Chinese PLA Medical SchoolInstitute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Second Medical Center of Chinese PLA General Hospital & Chinese PLA Medical SchoolAbstract Background Cardiovascular disease has become the leading cause of death worldwide, but there is a lack of data on whether cardiovascular health (CVH) is associated with elderly mortality in China. We investigated the relationship between the ideal CVH score of Chinese elderly and the all-cause mortality. Methods The Beijing Elderly Comprehensive Health Cohort Study included a total of 4,499 participants aged 60 years and above. The CVH metric was calculated at baseline and had a score ranging from 0 to 12. The relationship of CVH metrics with all-cause mortality was investigated using Cox proportional hazard regression analysis. The robustness of results was tested using subgroup and sensitivity analysis. Results The median CVH score among participants was 8.00 (2.00), with only 8.0% scoring 11–12 points. 667 deaths were observed during an average follow-up time of 8.2 years. Participants with a CVH score of 11–12 had a decreased risk of all-cause mortality when compared to those with a CVH score of 0–4(HR = 0.584, 95% CI: 0.373–0.913). Participants had a 7.5% lower risk of all-cause death with each unit higher CVH score (HR = 0.925, 95%CI: 0.885–0.967) with a linearly decreasing trend (P nonlinear = 0.575). The relationships were greater in younger elderly people and stroke patients (P interaction = 0.011 and 0.037. respectively). The consistency of significant trends in sensitivity analysis shows the robustness of association (P trend < 0.001). Conclusions Among the Chinese elderly, there was a linear relationship between improving CVH scores and a lower risk of all-cause mortality. Because of the enormous benefits brought by one point, strategies are essential for improving cardiovascular health attainment. Trial registration This study was registered at China Clinical Trial Registration Center (ChiCTR2100049866).https://doi.org/10.1186/s12877-023-04093-9Cardiovascular healthAll-cause mortalityElderlyCohort study |
| spellingShingle | Shimin Chen Haowei Li Shengshu Wang Shanshan Yang Shaohua Liu Yang Song Xuehang Li Rongrong Li Jianhua Wang Miao Liu Yao He Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China BMC Geriatrics Cardiovascular health All-cause mortality Elderly Cohort study |
| title | Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China |
| title_full | Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China |
| title_fullStr | Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China |
| title_full_unstemmed | Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China |
| title_short | Association of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China |
| title_sort | association of cardiovascular health at old age with all cause mortality a prospective cohort study in china |
| topic | Cardiovascular health All-cause mortality Elderly Cohort study |
| url | https://doi.org/10.1186/s12877-023-04093-9 |
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