Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation
Louis S Matza,1 Glenn A Phillips,2 Dennis A Revicki,1 Haya Ascher-Svanum,3 Karen G Malley,4 Andrew C Palsgrove,1 Douglas E Faries,3 Virginia Stauffer,3 Bruce J Kinon,3 A George Awad,5 Richard SE Keefe,6 Dieter Naber71Outcomes Research, United BioSource Corporation, Bethesda, MD, 2Formerly with Eli L...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2012-07-01
|
| Series: | Patient Preference and Adherence |
| Online Access: | http://www.dovepress.com/validation-of-a-patient-interview-for-assessing-reasons-for-antipsycho-a10396 |
| _version_ | 1818516163628367872 |
|---|---|
| author | Matza LS Phillips GA Revicki DA Ascher-Svanum H Malley KG Palsgrove AC Faries DE Stauffer V Kinon BJ Awad AG Keefe RS Naber D |
| author_facet | Matza LS Phillips GA Revicki DA Ascher-Svanum H Malley KG Palsgrove AC Faries DE Stauffer V Kinon BJ Awad AG Keefe RS Naber D |
| author_sort | Matza LS |
| collection | DOAJ |
| description | Louis S Matza,1 Glenn A Phillips,2 Dennis A Revicki,1 Haya Ascher-Svanum,3 Karen G Malley,4 Andrew C Palsgrove,1 Douglas E Faries,3 Virginia Stauffer,3 Bruce J Kinon,3 A George Awad,5 Richard SE Keefe,6 Dieter Naber71Outcomes Research, United BioSource Corporation, Bethesda, MD, 2Formerly with Eli Lilly and Company, Indianapolis, IN, 3Eli Lilly and Company, Indianapolis, IN, 4Malley Research Programming, Inc, Rockville, MD, USA; 5Department of Psychiatry and Behavioral Sciences; University of Toronto, Toronto, Canada; 6Duke University Medical Center, Durham NC, USA; 7Universitaetsklinikum Hamburg-Eppendorf, Hamburg, GermanyIntroduction: The Reasons for Antipsychotic Discontinuation Interview (RAD-I) was developed to assess patients’ perceptions of reasons for discontinuing or continuing an antipsychotic. The current study examined reliability and validity of domain scores representing three factors contributing to these treatment decisions: treatment benefits, adverse events, and distal reasons other than direct effects of the medication.Methods: Data were collected from patients with schizophrenia or schizoaffective disorder and their treating clinicians. For approximately 25% of patients, a second rater completed the RAD-I for assessment of inter-rater reliability.Results: All patients (n = 121; 81 discontinuation, 40 continuation) reported at least one reason for discontinuation or continuation (mean = 2.8 reasons for discontinuation; 3.4 for continuation). Inter-rater reliability was supported (kappas = 0.63–1.0). Validity of the discontinuation domain scores was supported by associations with symptom measures (the Positive and Negative Syndrome Scale for Schizophrenia, the Clinical Global Impression – Schizophrenia Scale; r = 0.30 to 0.51; all P < 0.01), patients’ primary reasons for discontinuation, and adverse events. However, the continuation domain scores were not significantly associated with these other indicators.Discussion: Results support the reliability, convergent validity, and known-groups validity of the RAD-I for assessing patients’ reasons for antipsychotic discontinuation. Further research is needed to examine validity of the RAD-I continuation section.Keywords: discontinuation, antipsychotic, schizophrenia, treatment continuation, patient-reported outcomes, instrument development |
| first_indexed | 2024-12-11T00:38:27Z |
| format | Article |
| id | doaj.art-2e308b2fb00f4386afb38c6fcf19255b |
| institution | Directory Open Access Journal |
| issn | 1177-889X |
| language | English |
| last_indexed | 2024-12-11T00:38:27Z |
| publishDate | 2012-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Preference and Adherence |
| spelling | doaj.art-2e308b2fb00f4386afb38c6fcf19255b2022-12-22T01:27:02ZengDove Medical PressPatient Preference and Adherence1177-889X2012-07-012012default521532Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuationMatza LSPhillips GARevicki DAAscher-Svanum HMalley KGPalsgrove ACFaries DEStauffer VKinon BJAwad AGKeefe RSNaber DLouis S Matza,1 Glenn A Phillips,2 Dennis A Revicki,1 Haya Ascher-Svanum,3 Karen G Malley,4 Andrew C Palsgrove,1 Douglas E Faries,3 Virginia Stauffer,3 Bruce J Kinon,3 A George Awad,5 Richard SE Keefe,6 Dieter Naber71Outcomes Research, United BioSource Corporation, Bethesda, MD, 2Formerly with Eli Lilly and Company, Indianapolis, IN, 3Eli Lilly and Company, Indianapolis, IN, 4Malley Research Programming, Inc, Rockville, MD, USA; 5Department of Psychiatry and Behavioral Sciences; University of Toronto, Toronto, Canada; 6Duke University Medical Center, Durham NC, USA; 7Universitaetsklinikum Hamburg-Eppendorf, Hamburg, GermanyIntroduction: The Reasons for Antipsychotic Discontinuation Interview (RAD-I) was developed to assess patients’ perceptions of reasons for discontinuing or continuing an antipsychotic. The current study examined reliability and validity of domain scores representing three factors contributing to these treatment decisions: treatment benefits, adverse events, and distal reasons other than direct effects of the medication.Methods: Data were collected from patients with schizophrenia or schizoaffective disorder and their treating clinicians. For approximately 25% of patients, a second rater completed the RAD-I for assessment of inter-rater reliability.Results: All patients (n = 121; 81 discontinuation, 40 continuation) reported at least one reason for discontinuation or continuation (mean = 2.8 reasons for discontinuation; 3.4 for continuation). Inter-rater reliability was supported (kappas = 0.63–1.0). Validity of the discontinuation domain scores was supported by associations with symptom measures (the Positive and Negative Syndrome Scale for Schizophrenia, the Clinical Global Impression – Schizophrenia Scale; r = 0.30 to 0.51; all P < 0.01), patients’ primary reasons for discontinuation, and adverse events. However, the continuation domain scores were not significantly associated with these other indicators.Discussion: Results support the reliability, convergent validity, and known-groups validity of the RAD-I for assessing patients’ reasons for antipsychotic discontinuation. Further research is needed to examine validity of the RAD-I continuation section.Keywords: discontinuation, antipsychotic, schizophrenia, treatment continuation, patient-reported outcomes, instrument developmenthttp://www.dovepress.com/validation-of-a-patient-interview-for-assessing-reasons-for-antipsycho-a10396 |
| spellingShingle | Matza LS Phillips GA Revicki DA Ascher-Svanum H Malley KG Palsgrove AC Faries DE Stauffer V Kinon BJ Awad AG Keefe RS Naber D Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation Patient Preference and Adherence |
| title | Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation |
| title_full | Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation |
| title_fullStr | Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation |
| title_full_unstemmed | Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation |
| title_short | Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation |
| title_sort | validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation |
| url | http://www.dovepress.com/validation-of-a-patient-interview-for-assessing-reasons-for-antipsycho-a10396 |
| work_keys_str_mv | AT matzals validationofapatientinterviewforassessingreasonsforantipsychoticdiscontinuationandcontinuation AT phillipsga validationofapatientinterviewforassessingreasonsforantipsychoticdiscontinuationandcontinuation AT revickida validationofapatientinterviewforassessingreasonsforantipsychoticdiscontinuationandcontinuation AT aschersvanumh validationofapatientinterviewforassessingreasonsforantipsychoticdiscontinuationandcontinuation AT malleykg validationofapatientinterviewforassessingreasonsforantipsychoticdiscontinuationandcontinuation AT palsgroveac validationofapatientinterviewforassessingreasonsforantipsychoticdiscontinuationandcontinuation AT fariesde validationofapatientinterviewforassessingreasonsforantipsychoticdiscontinuationandcontinuation AT staufferv validationofapatientinterviewforassessingreasonsforantipsychoticdiscontinuationandcontinuation AT kinonbj validationofapatientinterviewforassessingreasonsforantipsychoticdiscontinuationandcontinuation AT awadag validationofapatientinterviewforassessingreasonsforantipsychoticdiscontinuationandcontinuation AT keefers validationofapatientinterviewforassessingreasonsforantipsychoticdiscontinuationandcontinuation AT naberd validationofapatientinterviewforassessingreasonsforantipsychoticdiscontinuationandcontinuation |