Regulation of the p75 neurotrophin receptor attenuates neuroinflammation and stimulates hippocampal neurogenesis in experimental Streptococcus pneumoniae meningitis

Regulation of the p75 neurotrophin receptor attenuates neuroinflammation and stimulates hippocampal neurogenesis in experimental Streptococcus pneumoniae meningitis

Abstract Background Streptococcus pneumoniae meningitis is a destructive central nervous system (CNS) infection with acute and long-term neurological disorders. Previous studies suggest that p75NTR signaling influences cell survival, apoptosis, and proliferation in brain-injured conditions. However,...

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Bibliographic Details
Main Authors: Dandan Zhang, Shengnan Zhao, Zhijie Zhang, Danfeng Xu, Di Lian, Jing Wu, Dake He, Kun Sun, Ling Li
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Neuroinflammation
Subjects:
Streptococcus pneumoniae meningitis
Brain injury
p75 neurotrophin receptor
Neuroinflammation
Hippocampal neurogenesis
Online Access:https://doi.org/10.1186/s12974-021-02294-w

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