Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier
The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection. They constitute a cri...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/9/4677 |
| _version_ | 1797535896436736000 |
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| author | Judit Danis Mark Mellett |
| author_facet | Judit Danis Mark Mellett |
| author_sort | Judit Danis |
| collection | DOAJ |
| description | The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection. They constitute a critical arm of the innate immune response, though their functions are not restricted to pathogen recognition and members engage in controlling inflammasome activation, antigen-presentation, transcriptional regulation, cell death and also embryogenesis. NLRs are found from basal metazoans to plants, to zebrafish, mice and humans though functions of individual members can vary from species to species. NLRs also display highly wide-ranging tissue expression. Here, we discuss the importance of NLRs to the immune response at the epidermal barrier and summarise the known role of individual family members in the pathogenesis of skin disease. |
| first_indexed | 2024-03-10T11:51:52Z |
| format | Article |
| id | doaj.art-2e33132c0446447b93436e1a8c0c228f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:51:52Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2e33132c0446447b93436e1a8c0c228f2023-11-21T17:38:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01229467710.3390/ijms22094677Nod-Like Receptors in Host Defence and Disease at the Epidermal BarrierJudit Danis0Mark Mellett1MTA-SZTE Dermatological Research Group, Eötvös Loránd Research Network, Korányi Fasor 6, 6720 Szeged, HungaryDepartment of Dermatology, University Hospital Zürich (USZ), University of Zürich (UZH), Raemistrasse 100, 8091 Zürich, SwitzerlandThe nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection. They constitute a critical arm of the innate immune response, though their functions are not restricted to pathogen recognition and members engage in controlling inflammasome activation, antigen-presentation, transcriptional regulation, cell death and also embryogenesis. NLRs are found from basal metazoans to plants, to zebrafish, mice and humans though functions of individual members can vary from species to species. NLRs also display highly wide-ranging tissue expression. Here, we discuss the importance of NLRs to the immune response at the epidermal barrier and summarise the known role of individual family members in the pathogenesis of skin disease.https://www.mdpi.com/1422-0067/22/9/4677NLRsskinkeratinocyteinflammasomeskin disease |
| spellingShingle | Judit Danis Mark Mellett Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier International Journal of Molecular Sciences NLRs skin keratinocyte inflammasome skin disease |
| title | Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier |
| title_full | Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier |
| title_fullStr | Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier |
| title_full_unstemmed | Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier |
| title_short | Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier |
| title_sort | nod like receptors in host defence and disease at the epidermal barrier |
| topic | NLRs skin keratinocyte inflammasome skin disease |
| url | https://www.mdpi.com/1422-0067/22/9/4677 |
| work_keys_str_mv | AT juditdanis nodlikereceptorsinhostdefenceanddiseaseattheepidermalbarrier AT markmellett nodlikereceptorsinhostdefenceanddiseaseattheepidermalbarrier |