Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study
Abstract Background Prior research has established the correlation between insulin resistance (IR) and hypertension. While the association between triglyceride-glucose (TyG) index, a reliable surrogate marker of IR, and uncontrolled hypertension as well as arterial stiffness among individuals with h...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | https://doi.org/10.1186/s12933-023-02038-5 |
| _version_ | 1797630439869906944 |
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| author | Liao Tan Yubo Liu Jie Liu Guogang Zhang Zhaoya Liu Ruizheng Shi |
| author_facet | Liao Tan Yubo Liu Jie Liu Guogang Zhang Zhaoya Liu Ruizheng Shi |
| author_sort | Liao Tan |
| collection | DOAJ |
| description | Abstract Background Prior research has established the correlation between insulin resistance (IR) and hypertension. While the association between triglyceride-glucose (TyG) index, a reliable surrogate marker of IR, and uncontrolled hypertension as well as arterial stiffness among individuals with hypertension remains undisclosed. Methods In this study, a total of 8513 adults diagnosed with hypertension from the National Health and Nutrition Examination Survey 1999–2018 were included. The primary outcome of the study are arterial stiffness (represented with estimated pulse wave velocity, ePWV) and uncontrolled hypertension. Logistic regression model, subgroup analysis, restricted cubic spine, and smooth curve fitting curve were conducted to evaluate the association between the IR indicators and uncontrolled hypertension and arterial stiffness in individuals with hypertension. Results Among included participants, the overall prevalence of uncontrolled hypertension was 54.3%. After adjusting for all potential covariates, compared with the first quartile of TyG index, the risk of uncontrolled hypertension increased about 28% and 49% for participants in the third quartile (OR, 1.28; 95% CI 1.06–1.52) and the fourth quartile (OR, 1.49; 95% CI 1.21–1.89) of TyG index, respectively. The higher OR of TyG index was observed in participants taking antihypertensive medication [fourth quartile versus first quartile (OR, 2.03; 95% CI 1.37–3.11)]. Meanwhile, we explored the potential association between TyG index and arterial stiffness and found that TyG index was significantly associated with increased arterial stiffness (β for ePWV, 0.04; 95% CI 0.00–0.08; P = 0.039). However, traditional IR indicator HOMA-IR showed no significant positive correlation to uncontrolled hypertension as well as arterial stiffness in US adults with hypertension. Conclusion Elevated levels of the TyG index were positive associated with prevalence of uncontrolled hypertension and arterial stiffness among US adults with hypertension. |
| first_indexed | 2024-03-11T11:08:14Z |
| format | Article |
| id | doaj.art-2e3464519a5d48d584002009c1e5b152 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-03-11T11:08:14Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-2e3464519a5d48d584002009c1e5b1522023-11-12T12:05:51ZengBMCCardiovascular Diabetology1475-28402023-11-0122111210.1186/s12933-023-02038-5Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based studyLiao Tan0Yubo Liu1Jie Liu2Guogang Zhang3Zhaoya Liu4Ruizheng Shi5Department of Cardiology, Third Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South UniversityDepartment of Cardiology, Third Xiangya Hospital, Central South UniversityDepartment of the Geriatrics, Third Xiangya Hospital, Central South UniversityDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South UniversityAbstract Background Prior research has established the correlation between insulin resistance (IR) and hypertension. While the association between triglyceride-glucose (TyG) index, a reliable surrogate marker of IR, and uncontrolled hypertension as well as arterial stiffness among individuals with hypertension remains undisclosed. Methods In this study, a total of 8513 adults diagnosed with hypertension from the National Health and Nutrition Examination Survey 1999–2018 were included. The primary outcome of the study are arterial stiffness (represented with estimated pulse wave velocity, ePWV) and uncontrolled hypertension. Logistic regression model, subgroup analysis, restricted cubic spine, and smooth curve fitting curve were conducted to evaluate the association between the IR indicators and uncontrolled hypertension and arterial stiffness in individuals with hypertension. Results Among included participants, the overall prevalence of uncontrolled hypertension was 54.3%. After adjusting for all potential covariates, compared with the first quartile of TyG index, the risk of uncontrolled hypertension increased about 28% and 49% for participants in the third quartile (OR, 1.28; 95% CI 1.06–1.52) and the fourth quartile (OR, 1.49; 95% CI 1.21–1.89) of TyG index, respectively. The higher OR of TyG index was observed in participants taking antihypertensive medication [fourth quartile versus first quartile (OR, 2.03; 95% CI 1.37–3.11)]. Meanwhile, we explored the potential association between TyG index and arterial stiffness and found that TyG index was significantly associated with increased arterial stiffness (β for ePWV, 0.04; 95% CI 0.00–0.08; P = 0.039). However, traditional IR indicator HOMA-IR showed no significant positive correlation to uncontrolled hypertension as well as arterial stiffness in US adults with hypertension. Conclusion Elevated levels of the TyG index were positive associated with prevalence of uncontrolled hypertension and arterial stiffness among US adults with hypertension.https://doi.org/10.1186/s12933-023-02038-5Triglyceride-glucose indexInsulin resistanceHypertensionNHANESArterial stiffness |
| spellingShingle | Liao Tan Yubo Liu Jie Liu Guogang Zhang Zhaoya Liu Ruizheng Shi Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study Cardiovascular Diabetology Triglyceride-glucose index Insulin resistance Hypertension NHANES Arterial stiffness |
| title | Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study |
| title_full | Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study |
| title_fullStr | Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study |
| title_full_unstemmed | Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study |
| title_short | Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study |
| title_sort | association between insulin resistance and uncontrolled hypertension and arterial stiffness among us adults a population based study |
| topic | Triglyceride-glucose index Insulin resistance Hypertension NHANES Arterial stiffness |
| url | https://doi.org/10.1186/s12933-023-02038-5 |
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