Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends
In the present overview, we describe the bases of intercalation of small molecules (cationic and polar neutral compounds) in DNA. We briefly describe the importance of DNA structure and principles of intercalation. Selected syntheses, possibilities and applications are shown to exemplify the importa...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2009-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/14/5/1725/ |
| _version_ | 1811244357266702336 |
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| author | Alexandre A. M. Lapis Brenno A. D. Neto |
| author_facet | Alexandre A. M. Lapis Brenno A. D. Neto |
| author_sort | Alexandre A. M. Lapis |
| collection | DOAJ |
| description | In the present overview, we describe the bases of intercalation of small molecules (cationic and polar neutral compounds) in DNA. We briefly describe the importance of DNA structure and principles of intercalation. Selected syntheses, possibilities and applications are shown to exemplify the importance, drawbacks and challenges in this pertinent, new, and exciting research area. Additionally, some clinical applications (molecular processes, cancer therapy and others) and trends are described. |
| first_indexed | 2024-04-12T14:23:59Z |
| format | Article |
| id | doaj.art-2e3512785b864065aa66a4ce00a817d1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T14:23:59Z |
| publishDate | 2009-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2e3512785b864065aa66a4ce00a817d12022-12-22T03:29:29ZengMDPI AGMolecules1420-30492009-05-011451725174610.3390/molecules14051725Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and TrendsAlexandre A. M. LapisBrenno A. D. NetoIn the present overview, we describe the bases of intercalation of small molecules (cationic and polar neutral compounds) in DNA. We briefly describe the importance of DNA structure and principles of intercalation. Selected syntheses, possibilities and applications are shown to exemplify the importance, drawbacks and challenges in this pertinent, new, and exciting research area. Additionally, some clinical applications (molecular processes, cancer therapy and others) and trends are described.http://www.mdpi.com/1420-3049/14/5/1725/DNARNAphotointercalatorsfluorescencerational designtherapycancer |
| spellingShingle | Alexandre A. M. Lapis Brenno A. D. Neto Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends Molecules DNA RNA photointercalators fluorescence rational design therapy cancer |
| title | Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends |
| title_full | Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends |
| title_fullStr | Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends |
| title_full_unstemmed | Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends |
| title_short | Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends |
| title_sort | recent developments in the chemistry of deoxyribonucleic acid dna intercalators principles design synthesis applications and trends |
| topic | DNA RNA photointercalators fluorescence rational design therapy cancer |
| url | http://www.mdpi.com/1420-3049/14/5/1725/ |
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