Mechanism of pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicine
Neurodegenerative diseases (NDs) are disorders characterized by degenerative degeneration of neurons and loss of their function. NDs have a complicated pathophysiology, of which neuroinflammation and neuronal death are significant factors. The inflammatory process known as pyroptosis (“fiery death”)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1122104/full |
| _version_ | 1797953935342829568 |
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| author | Yanfang Liao Xue Wang Liting Huang Hu Qian Wei Liu Wei Liu |
| author_facet | Yanfang Liao Xue Wang Liting Huang Hu Qian Wei Liu Wei Liu |
| author_sort | Yanfang Liao |
| collection | DOAJ |
| description | Neurodegenerative diseases (NDs) are disorders characterized by degenerative degeneration of neurons and loss of their function. NDs have a complicated pathophysiology, of which neuroinflammation and neuronal death are significant factors. The inflammatory process known as pyroptosis (“fiery death”) is caused by a family of pore-forming proteins called Gasdermins (GSDMs), which appears downstream from the activation of the inflammasome. Clear evidence of enhanced pyroptosis-related proteins activity in common NDs has coincided with abnormal aggregation of pathological proteins (such as Aβ, tau, α-synuclein et al.), making pyroptosis an attractive direction for the recent study of NDs. The purpose of this review is to provide an overview of the molecular mechanisms driving pyroptosis, the mechanistic links between pyroptosis and NDs, and emerging therapeutic strategies in Traditional Chinese Medicine (TCM) to inhibit pyroptosis for the treatment of NDs. |
| first_indexed | 2024-04-10T23:09:48Z |
| format | Article |
| id | doaj.art-2e35304a32c3421bbf889ec107462418 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-10T23:09:48Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2e35304a32c3421bbf889ec1074624182023-01-13T05:52:33ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-01-011410.3389/fphar.2023.11221041122104Mechanism of pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicineYanfang Liao0Xue Wang1Liting Huang2Hu Qian3Wei Liu4Wei Liu5Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaDepartment of Breast Cancer Oncology, Foshan No 1 Hospital, Foshan, ChinaThe First Clinical Medicine College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaIntegrative Cancer Centre, The First Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, ChinaNeurodegenerative diseases (NDs) are disorders characterized by degenerative degeneration of neurons and loss of their function. NDs have a complicated pathophysiology, of which neuroinflammation and neuronal death are significant factors. The inflammatory process known as pyroptosis (“fiery death”) is caused by a family of pore-forming proteins called Gasdermins (GSDMs), which appears downstream from the activation of the inflammasome. Clear evidence of enhanced pyroptosis-related proteins activity in common NDs has coincided with abnormal aggregation of pathological proteins (such as Aβ, tau, α-synuclein et al.), making pyroptosis an attractive direction for the recent study of NDs. The purpose of this review is to provide an overview of the molecular mechanisms driving pyroptosis, the mechanistic links between pyroptosis and NDs, and emerging therapeutic strategies in Traditional Chinese Medicine (TCM) to inhibit pyroptosis for the treatment of NDs.https://www.frontiersin.org/articles/10.3389/fphar.2023.1122104/fullpyroptosisneurodegenerative diseasestraditional Chinese medicineneuroinflammationneuroprotection |
| spellingShingle | Yanfang Liao Xue Wang Liting Huang Hu Qian Wei Liu Wei Liu Mechanism of pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicine Frontiers in Pharmacology pyroptosis neurodegenerative diseases traditional Chinese medicine neuroinflammation neuroprotection |
| title | Mechanism of pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicine |
| title_full | Mechanism of pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicine |
| title_fullStr | Mechanism of pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicine |
| title_full_unstemmed | Mechanism of pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicine |
| title_short | Mechanism of pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicine |
| title_sort | mechanism of pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional chinese medicine |
| topic | pyroptosis neurodegenerative diseases traditional Chinese medicine neuroinflammation neuroprotection |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1122104/full |
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