Occurrence of multidrug-resistant tuberculous meningitis associated with injury during spinal surgery: A case report
Here we describe a case of multidrug-resistant tuberculous meningitis associated with injury inflicted during spinal surgery. A 54-year-old man was diagnosed with multidrug-resistant spinal tuberculosis (TB). Anterior debridement and fusion with posterior fusion and instrumentation were conducted to...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-10-01
|
| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034120304883 |
| _version_ | 1811327051302436864 |
|---|---|
| author | Mingwei Zhao Ling Liu Miao Wang Weidong Zhou Minglei Zhang Han Xiao Yu Pang |
| author_facet | Mingwei Zhao Ling Liu Miao Wang Weidong Zhou Minglei Zhang Han Xiao Yu Pang |
| author_sort | Mingwei Zhao |
| collection | DOAJ |
| description | Here we describe a case of multidrug-resistant tuberculous meningitis associated with injury inflicted during spinal surgery. A 54-year-old man was diagnosed with multidrug-resistant spinal tuberculosis (TB). Anterior debridement and fusion with posterior fusion and instrumentation were conducted to remove damaged bone and TB-associated granulomatous tissue. After surgical decompression, a lancet wound (about 5 mm in length) was discovered in the cerebral dura mater at the L3 position of the vertebral body. At four weeks post-surgery, the patient experienced fever, hemiparesis, and aphasia. Cerebrospinal fluid (CSF) findings were consistent with TB meningitis, while in vitro susceptibility test results confirmed that the patient had multidrug-resistant TB. Our data highlight a possible TBM infection associated with a surgical lesion in a spinal TB patient. Rapid molecular diagnostics are urgently needed to formulate efficacious regimens for treating these patients. |
| first_indexed | 2024-04-13T15:00:55Z |
| format | Article |
| id | doaj.art-2e37cbe97f3a49edab25399ec5b64147 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-04-13T15:00:55Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-2e37cbe97f3a49edab25399ec5b641472022-12-22T02:42:18ZengElsevierJournal of Infection and Public Health1876-03412020-10-01131015861588Occurrence of multidrug-resistant tuberculous meningitis associated with injury during spinal surgery: A case reportMingwei Zhao0Ling Liu1Miao Wang2Weidong Zhou3Minglei Zhang4Han Xiao5Yu Pang6Department of Surgery, Qingdao Chest Hospital, Qingdao, 266043, ChinaDepartment of Cadre Health, Qingdao Municipal Hospital, Qingdao 266000, ChinaDepartment of Surgery, Qingdao Chest Hospital, Qingdao, 266043, ChinaDepartment of Surgery, Qingdao Chest Hospital, Qingdao, 266043, ChinaDepartment of Surgery, Qingdao Chest Hospital, Qingdao, 266043, ChinaDepartment of Surgery, Qingdao Chest Hospital, Qingdao, 266043, ChinaNational Clinical Laboratory on Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing 101149, China; Corresponding author at: No. 9, Beiguan Street, Tongzhou District, Beijing 101149, China.Here we describe a case of multidrug-resistant tuberculous meningitis associated with injury inflicted during spinal surgery. A 54-year-old man was diagnosed with multidrug-resistant spinal tuberculosis (TB). Anterior debridement and fusion with posterior fusion and instrumentation were conducted to remove damaged bone and TB-associated granulomatous tissue. After surgical decompression, a lancet wound (about 5 mm in length) was discovered in the cerebral dura mater at the L3 position of the vertebral body. At four weeks post-surgery, the patient experienced fever, hemiparesis, and aphasia. Cerebrospinal fluid (CSF) findings were consistent with TB meningitis, while in vitro susceptibility test results confirmed that the patient had multidrug-resistant TB. Our data highlight a possible TBM infection associated with a surgical lesion in a spinal TB patient. Rapid molecular diagnostics are urgently needed to formulate efficacious regimens for treating these patients.http://www.sciencedirect.com/science/article/pii/S1876034120304883Mycobacterium tuberculosisSpineMultidrug-resistanceTuberculous meningitis |
| spellingShingle | Mingwei Zhao Ling Liu Miao Wang Weidong Zhou Minglei Zhang Han Xiao Yu Pang Occurrence of multidrug-resistant tuberculous meningitis associated with injury during spinal surgery: A case report Journal of Infection and Public Health Mycobacterium tuberculosis Spine Multidrug-resistance Tuberculous meningitis |
| title | Occurrence of multidrug-resistant tuberculous meningitis associated with injury during spinal surgery: A case report |
| title_full | Occurrence of multidrug-resistant tuberculous meningitis associated with injury during spinal surgery: A case report |
| title_fullStr | Occurrence of multidrug-resistant tuberculous meningitis associated with injury during spinal surgery: A case report |
| title_full_unstemmed | Occurrence of multidrug-resistant tuberculous meningitis associated with injury during spinal surgery: A case report |
| title_short | Occurrence of multidrug-resistant tuberculous meningitis associated with injury during spinal surgery: A case report |
| title_sort | occurrence of multidrug resistant tuberculous meningitis associated with injury during spinal surgery a case report |
| topic | Mycobacterium tuberculosis Spine Multidrug-resistance Tuberculous meningitis |
| url | http://www.sciencedirect.com/science/article/pii/S1876034120304883 |
| work_keys_str_mv | AT mingweizhao occurrenceofmultidrugresistanttuberculousmeningitisassociatedwithinjuryduringspinalsurgeryacasereport AT lingliu occurrenceofmultidrugresistanttuberculousmeningitisassociatedwithinjuryduringspinalsurgeryacasereport AT miaowang occurrenceofmultidrugresistanttuberculousmeningitisassociatedwithinjuryduringspinalsurgeryacasereport AT weidongzhou occurrenceofmultidrugresistanttuberculousmeningitisassociatedwithinjuryduringspinalsurgeryacasereport AT mingleizhang occurrenceofmultidrugresistanttuberculousmeningitisassociatedwithinjuryduringspinalsurgeryacasereport AT hanxiao occurrenceofmultidrugresistanttuberculousmeningitisassociatedwithinjuryduringspinalsurgeryacasereport AT yupang occurrenceofmultidrugresistanttuberculousmeningitisassociatedwithinjuryduringspinalsurgeryacasereport |