Effect of Viscosity and Density of Substance on Dielectric Properties of Medicinal Compounds in Solution
Complex permittivity in terms of dielectric constant (ε') and dielectric loss (ε") of medicinal compound paracetamol in dimethyl sulfoxide (DMSO) solvent was determined with different weight fractions at microwave frequency 9.85 GHz at constant temperature 27 ℃. The information on dielectr...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2020-12-01
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| Series: | Nano Biomedicine and Engineering |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.5101/nbe.v12i4.p351-357 |
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| author | Jinan Fadhil Mahdi Ansari Abdul Jaleel Abdul Haque Mazahar Ahmed Nazeeruddin Farooqui Yusuf Hanif Shaikh |
| author_facet | Jinan Fadhil Mahdi Ansari Abdul Jaleel Abdul Haque Mazahar Ahmed Nazeeruddin Farooqui Yusuf Hanif Shaikh |
| author_sort | Jinan Fadhil Mahdi |
| collection | DOAJ |
| description | Complex permittivity in terms of dielectric constant (ε') and dielectric loss (ε") of medicinal compound paracetamol in dimethyl sulfoxide (DMSO) solvent was determined with different weight fractions at microwave frequency 9.85 GHz at constant temperature 27 ℃. The information on dielectric properties is related to the properties of the substance for preparation of granules while making dosage forms like tablets and capsules. Refractive index (nD), dielectricconstant (ε') and dielectric loss (ε") were used for the measurement of relaxation time (τ). The viscosity (η) and density of paracetamol in DMSO were determined using a conventional Ostwald's viscometer and specific gravity bottle respectively. The aim of the present work was to study the dielectric properties of the drugs and attempted to determine their correlations with density and viscosity to understand the behavior of the dielectric properties under different conditions like a concentration in solution. It was observed that there was a strong correlation of dielectric properties like dielectric constant, dielectric loss and dielectric relaxation time with viscosity and density. The absolute values of correlation coefficient (R) were in the range of 0.946 to 0.987 for paracetamol-DMSO system, indicating a strong correlation. |
| first_indexed | 2024-03-11T21:43:24Z |
| format | Article |
| id | doaj.art-2e3ad2f595774b13b8e0768ac124f046 |
| institution | Directory Open Access Journal |
| issn | 2150-5578 |
| language | English |
| last_indexed | 2024-03-11T21:43:24Z |
| publishDate | 2020-12-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj.art-2e3ad2f595774b13b8e0768ac124f0462023-09-26T11:04:26ZengTsinghua University PressNano Biomedicine and Engineering2150-55782020-12-0112435135710.5101/nbe.v12i4.p351-357Effect of Viscosity and Density of Substance on Dielectric Properties of Medicinal Compounds in SolutionJinan Fadhil Mahdi0Ansari Abdul Jaleel Abdul Haque1Mazahar Ahmed Nazeeruddin Farooqui2Yusuf Hanif Shaikh3College of Electrical Engineering Techniques, Middle Technical University, Ministry of Higher Education and Scientific Research, IraqDepartment of Physics and Electronics, Maulana Azad College of Arts, Science and Commerce, Aurangabad, Maharashtra, IndiaDepartment of Chemistry, Maulana Azad College of Arts, Science and Commerce, Aurangabad, Maharashtra, IndiaDepartment of Physics and Electronics, Shivaji College, Kannad, Aurangabad, Maharashtra, IndiaComplex permittivity in terms of dielectric constant (ε') and dielectric loss (ε") of medicinal compound paracetamol in dimethyl sulfoxide (DMSO) solvent was determined with different weight fractions at microwave frequency 9.85 GHz at constant temperature 27 ℃. The information on dielectric properties is related to the properties of the substance for preparation of granules while making dosage forms like tablets and capsules. Refractive index (nD), dielectricconstant (ε') and dielectric loss (ε") were used for the measurement of relaxation time (τ). The viscosity (η) and density of paracetamol in DMSO were determined using a conventional Ostwald's viscometer and specific gravity bottle respectively. The aim of the present work was to study the dielectric properties of the drugs and attempted to determine their correlations with density and viscosity to understand the behavior of the dielectric properties under different conditions like a concentration in solution. It was observed that there was a strong correlation of dielectric properties like dielectric constant, dielectric loss and dielectric relaxation time with viscosity and density. The absolute values of correlation coefficient (R) were in the range of 0.946 to 0.987 for paracetamol-DMSO system, indicating a strong correlation.https://www.sciopen.com/article/10.5101/nbe.v12i4.p351-357dielectric constantmicrowave benchmagnetic stirrerostwald's viscometerspecific gravity bottlerelaxation timedebye model |
| spellingShingle | Jinan Fadhil Mahdi Ansari Abdul Jaleel Abdul Haque Mazahar Ahmed Nazeeruddin Farooqui Yusuf Hanif Shaikh Effect of Viscosity and Density of Substance on Dielectric Properties of Medicinal Compounds in Solution Nano Biomedicine and Engineering dielectric constant microwave bench magnetic stirrer ostwald's viscometer specific gravity bottle relaxation time debye model |
| title | Effect of Viscosity and Density of Substance on Dielectric Properties of Medicinal Compounds in Solution |
| title_full | Effect of Viscosity and Density of Substance on Dielectric Properties of Medicinal Compounds in Solution |
| title_fullStr | Effect of Viscosity and Density of Substance on Dielectric Properties of Medicinal Compounds in Solution |
| title_full_unstemmed | Effect of Viscosity and Density of Substance on Dielectric Properties of Medicinal Compounds in Solution |
| title_short | Effect of Viscosity and Density of Substance on Dielectric Properties of Medicinal Compounds in Solution |
| title_sort | effect of viscosity and density of substance on dielectric properties of medicinal compounds in solution |
| topic | dielectric constant microwave bench magnetic stirrer ostwald's viscometer specific gravity bottle relaxation time debye model |
| url | https://www.sciopen.com/article/10.5101/nbe.v12i4.p351-357 |
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