The DNA damage response in mammalian oocytes

The DNA damage response in mammalian oocytes

DNA damage is one of the most common insults that challenge all cells. To cope, an elaborate molecular and cellular response has evolved to sense, respond to and correct the damage. This allows the maintenance of DNA fidelity essential for normal cell viability and the prevention of genomic instabil...

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Bibliographic Details
Main Authors: John eCarroll, Petros eMarangos
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Genetics
Subjects:
Apoptosis
Meiosis
Oocytes
DNA damage response
ATM
DNA damage checkpoint
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00117/full

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