Photodynamic Therapy by Diaryl-Porphyrins to Control the Growth of <i>Candida albicans</i>
<i>Candida albicans</i> is an opportunistic pathogen that often causes skin infections such as oral thrush, nail fungus, athlete’s foot, and diaper rash. Under particular conditions, <i>C. albicans</i> alters the natural balance of the host microbiota, and as a result, the sk...
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| Format: | Article |
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MDPI AG
2020-05-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/7/2/31 |
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| author | Viviana Teresa Orlandi Eleonora Martegani Fabrizio Bolognese Nicola Trivellin Olga Maťátková Martina Paldrychová Andreina Baj Enrico Caruso |
| author_facet | Viviana Teresa Orlandi Eleonora Martegani Fabrizio Bolognese Nicola Trivellin Olga Maťátková Martina Paldrychová Andreina Baj Enrico Caruso |
| author_sort | Viviana Teresa Orlandi |
| collection | DOAJ |
| description | <i>Candida albicans</i> is an opportunistic pathogen that often causes skin infections such as oral thrush, nail fungus, athlete’s foot, and diaper rash. Under particular conditions, <i>C. albicans</i> alters the natural balance of the host microbiota, and as a result, the skin or its accessory structures lose their function and appearance. Conventional antimycotic drugs are highly toxic to host tissues, and long-lasting drug administration induces the arising of resistant strains that make the antimycotic therapy ineffective. Among new antimicrobial approaches to combine with traditional drugs, light-based techniques are very promising. In this study, a panel of dyes was considered for photodynamic therapy (PDT) applications to control the growth of the model strain <i>C. albicans</i> ATCC 14053. The chosen photosensitizers (PSs) belong to the family of synthetic porphyrins, and in particular, they are diaryl-porphyrins. Among these, two monocationic PSs were shown to be particularly efficient in killing <i>C. albicans</i> upon irradiation with light at 410 nm, in a light-dose-dependent manner. The elicited photo-oxidative stress induced the loss of the internal cellular architecture and death. The photodynamic treatment was also successful in inhibiting the biofilm formation of clinical <i>C. albicans</i> strains. In conclusion, this study supports the great potential of diaryl-porphyrins in antimicrobial PDT to control the growth of yeasts on body tissues easily reachable by light sources, such as skin and oral cavity. |
| first_indexed | 2024-03-10T19:56:14Z |
| format | Article |
| id | doaj.art-2e3c8ed031334020be6ab4ffd7165eeb |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-03-10T19:56:14Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-2e3c8ed031334020be6ab4ffd7165eeb2023-11-19T23:54:46ZengMDPI AGCosmetics2079-92842020-05-01723110.3390/cosmetics7020031Photodynamic Therapy by Diaryl-Porphyrins to Control the Growth of <i>Candida albicans</i>Viviana Teresa Orlandi0Eleonora Martegani1Fabrizio Bolognese2Nicola Trivellin3Olga Maťátková4Martina Paldrychová5Andreina Baj6Enrico Caruso7Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, ItalyDepartment of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, ItalyDepartment of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, ItalyDepartment of Industrial Engineering, University of Padua, 35131 Padua, ItalyDepartment of Biotechnology, University of Chemistry and Technology Prague, 166 28 Praha, Czech RepublicDepartment of Biotechnology, University of Chemistry and Technology Prague, 166 28 Praha, Czech RepublicDepartment of Medicine and Surgery, University of Insubria, 21100 Varese, ItalyDepartment of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy<i>Candida albicans</i> is an opportunistic pathogen that often causes skin infections such as oral thrush, nail fungus, athlete’s foot, and diaper rash. Under particular conditions, <i>C. albicans</i> alters the natural balance of the host microbiota, and as a result, the skin or its accessory structures lose their function and appearance. Conventional antimycotic drugs are highly toxic to host tissues, and long-lasting drug administration induces the arising of resistant strains that make the antimycotic therapy ineffective. Among new antimicrobial approaches to combine with traditional drugs, light-based techniques are very promising. In this study, a panel of dyes was considered for photodynamic therapy (PDT) applications to control the growth of the model strain <i>C. albicans</i> ATCC 14053. The chosen photosensitizers (PSs) belong to the family of synthetic porphyrins, and in particular, they are diaryl-porphyrins. Among these, two monocationic PSs were shown to be particularly efficient in killing <i>C. albicans</i> upon irradiation with light at 410 nm, in a light-dose-dependent manner. The elicited photo-oxidative stress induced the loss of the internal cellular architecture and death. The photodynamic treatment was also successful in inhibiting the biofilm formation of clinical <i>C. albicans</i> strains. In conclusion, this study supports the great potential of diaryl-porphyrins in antimicrobial PDT to control the growth of yeasts on body tissues easily reachable by light sources, such as skin and oral cavity.https://www.mdpi.com/2079-9284/7/2/31<i>Candida albicans</i>photodynamic treatmentporphyrinsPDTantifungal |
| spellingShingle | Viviana Teresa Orlandi Eleonora Martegani Fabrizio Bolognese Nicola Trivellin Olga Maťátková Martina Paldrychová Andreina Baj Enrico Caruso Photodynamic Therapy by Diaryl-Porphyrins to Control the Growth of <i>Candida albicans</i> Cosmetics <i>Candida albicans</i> photodynamic treatment porphyrins PDT antifungal |
| title | Photodynamic Therapy by Diaryl-Porphyrins to Control the Growth of <i>Candida albicans</i> |
| title_full | Photodynamic Therapy by Diaryl-Porphyrins to Control the Growth of <i>Candida albicans</i> |
| title_fullStr | Photodynamic Therapy by Diaryl-Porphyrins to Control the Growth of <i>Candida albicans</i> |
| title_full_unstemmed | Photodynamic Therapy by Diaryl-Porphyrins to Control the Growth of <i>Candida albicans</i> |
| title_short | Photodynamic Therapy by Diaryl-Porphyrins to Control the Growth of <i>Candida albicans</i> |
| title_sort | photodynamic therapy by diaryl porphyrins to control the growth of i candida albicans i |
| topic | <i>Candida albicans</i> photodynamic treatment porphyrins PDT antifungal |
| url | https://www.mdpi.com/2079-9284/7/2/31 |
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