Fisheye piezo polymer detector for scanning optoacoustic angiography of experimental neoplasms
A number of optoacoustic (or photoacoustic) microscopy and mesoscopy techniques have successfully been employed for non-invasive tumor angiography. However, accurate rendering of tortuous and multidirectional neoplastic vessels is commonly hindered by the limited aperture size, narrow bandwidth and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597923000605 |
| _version_ | 1797801028075126784 |
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| author | Alexey Kurnikov Grigory Volkov Anna Orlova Andrey Kovalchuk Yulia Khochenkova Daniel Razansky Pavel Subochev |
| author_facet | Alexey Kurnikov Grigory Volkov Anna Orlova Andrey Kovalchuk Yulia Khochenkova Daniel Razansky Pavel Subochev |
| author_sort | Alexey Kurnikov |
| collection | DOAJ |
| description | A number of optoacoustic (or photoacoustic) microscopy and mesoscopy techniques have successfully been employed for non-invasive tumor angiography. However, accurate rendering of tortuous and multidirectional neoplastic vessels is commonly hindered by the limited aperture size, narrow bandwidth and insufficient angular coverage of commercially available ultrasound transducers. We exploited the excellent flexibility and elasticity of a piezo polymer (PVDF) material to devise a fisheye-shape ultrasound detector with a high numerical aperture of 0.9, wide 1–30 MHz detection bandwidth and 27 mm diameter aperture suitable for imaging tumors of various size. We show theoretically and experimentally that the wide detector’s view-angle and bandwidth are paramount for achieving a detailed visualization of the intricate arbitrarily-oriented neovasculature in experimental tumors. The developed approach is shown to be well adapted to the tasks of experimental oncology thus allows to better exploit the angiographic potential of optoacoustics. |
| first_indexed | 2024-03-13T04:44:11Z |
| format | Article |
| id | doaj.art-2e3cd0c306e34fd48732ba8a98ed7c34 |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-03-13T04:44:11Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-2e3cd0c306e34fd48732ba8a98ed7c342023-06-19T04:28:06ZengElsevierPhotoacoustics2213-59792023-06-0131100507Fisheye piezo polymer detector for scanning optoacoustic angiography of experimental neoplasmsAlexey Kurnikov0Grigory Volkov1Anna Orlova2Andrey Kovalchuk3Yulia Khochenkova4Daniel Razansky5Pavel Subochev6Institute of Applied Physics, Russian Academy of Sciences, 46 Ulyanov Str., Nizhny Novgorod 603950, RussiaInstitute of Applied Physics, Russian Academy of Sciences, 46 Ulyanov Str., Nizhny Novgorod 603950, RussiaInstitute of Applied Physics, Russian Academy of Sciences, 46 Ulyanov Str., Nizhny Novgorod 603950, RussiaInstitute of Applied Physics, Russian Academy of Sciences, 46 Ulyanov Str., Nizhny Novgorod 603950, RussiaNational Medical Research Center of Oncology named after N. N. Blokhin, Kashirskoe highway 23, Moscow 115522, RussiaInstitute of Pharmacology and Toxicology, Faculty of Medicine, UZH Zurich, Rämistrasse 71, Zurich 8006, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Gloriastrasse 35, Zurich 8092, Switzerland; Corresponding author at: Institute of Pharmacology and Toxicology, Faculty of Medicine, UZH Zurich, Rämistrasse 71, Zurich 8006, Switzerland.Institute of Applied Physics, Russian Academy of Sciences, 46 Ulyanov Str., Nizhny Novgorod 603950, RussiaA number of optoacoustic (or photoacoustic) microscopy and mesoscopy techniques have successfully been employed for non-invasive tumor angiography. However, accurate rendering of tortuous and multidirectional neoplastic vessels is commonly hindered by the limited aperture size, narrow bandwidth and insufficient angular coverage of commercially available ultrasound transducers. We exploited the excellent flexibility and elasticity of a piezo polymer (PVDF) material to devise a fisheye-shape ultrasound detector with a high numerical aperture of 0.9, wide 1–30 MHz detection bandwidth and 27 mm diameter aperture suitable for imaging tumors of various size. We show theoretically and experimentally that the wide detector’s view-angle and bandwidth are paramount for achieving a detailed visualization of the intricate arbitrarily-oriented neovasculature in experimental tumors. The developed approach is shown to be well adapted to the tasks of experimental oncology thus allows to better exploit the angiographic potential of optoacoustics.http://www.sciencedirect.com/science/article/pii/S2213597923000605Optoacoustic mesoscopyExperimental neoplasmsLimited viewOptoacousticsPhotoacousticsBiophotonics |
| spellingShingle | Alexey Kurnikov Grigory Volkov Anna Orlova Andrey Kovalchuk Yulia Khochenkova Daniel Razansky Pavel Subochev Fisheye piezo polymer detector for scanning optoacoustic angiography of experimental neoplasms Photoacoustics Optoacoustic mesoscopy Experimental neoplasms Limited view Optoacoustics Photoacoustics Biophotonics |
| title | Fisheye piezo polymer detector for scanning optoacoustic angiography of experimental neoplasms |
| title_full | Fisheye piezo polymer detector for scanning optoacoustic angiography of experimental neoplasms |
| title_fullStr | Fisheye piezo polymer detector for scanning optoacoustic angiography of experimental neoplasms |
| title_full_unstemmed | Fisheye piezo polymer detector for scanning optoacoustic angiography of experimental neoplasms |
| title_short | Fisheye piezo polymer detector for scanning optoacoustic angiography of experimental neoplasms |
| title_sort | fisheye piezo polymer detector for scanning optoacoustic angiography of experimental neoplasms |
| topic | Optoacoustic mesoscopy Experimental neoplasms Limited view Optoacoustics Photoacoustics Biophotonics |
| url | http://www.sciencedirect.com/science/article/pii/S2213597923000605 |
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