Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response

Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response

Summary: Treatment options for patients with NRAS-mutant melanoma are limited and lack an efficient targeted drug combination that significantly increases overall and progression-free survival. In addition, targeted therapy success is hampered by the inevitable emergence of drug resistance. A thorou...

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Bibliographic Details
Main Authors: Tijana Randic, Stefano Magni, Demetra Philippidou, Christiane Margue, Kamil Grzyb, Jasmin Renate Preis, Joanna Patrycja Wroblewska, Petr V. Nazarov, Michel Mittelbronn, Katrin B.M. Frauenknecht, Alexander Skupin, Stephanie Kreis
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
NRAS-mutant melanoma
MEK/CDK4/6 co-inhibition
drug resistance
single-cell RNA-sequencing
P2RX7
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723007076

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