Sensitivity and Specificity of Galectin-3 and Glypican-3 in Follicular-Patterned and Other Thyroid Neoplasms
Introduction: Diagnosing follicular-patterned thyroid neoplasm can be quiet challenging in some cases, where an immunohistochemical profiling becomes mandatory. Galectin-3 may be a helpful tool for classical PTC diagnosis, but it cannot be considered as a diagnostic marker of malignancy. Glypica...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7430/18375_CE[Ra1]_F(GH)_PF1(Ro_Om)_PFA(NC_AK)_PF2(PAG).pdf |
| Summary: | Introduction: Diagnosing follicular-patterned thyroid neoplasm can
be quiet challenging in some cases, where an immunohistochemical
profiling becomes mandatory. Galectin-3 may be a helpful tool
for classical PTC diagnosis, but it cannot be considered as a
diagnostic marker of malignancy. Glypican-3, in contrast, is not
thoroughly studied in thyroid neoplasms.
Aim: Determine the sensitivity and specificity of galectin-3
and glypican-3 in diagnosing thyroid carcinoma and follicularpatterned thyroid carcinoma.
Materials and Methods: A retrospective study was conducted
on archival blocks diagnosed from pathology department
between 2010 and 2012 including 17 cases of follicular adenoma,
16 cases of Classic Papillary Thyroid Carcinoma (PTC), 6 cases
of Follicular Variant of Papillary Thyroid Carcinoma (FVPTC), 3
cases of follicular carcinoma, 5 cases of medullary carcinoma
and 1 case of Hürthle cell carcinoma. The nearby non neoplastic
(normal) thyroid follicles present in both adenoma and carcinoma
cases were also evaluated.
Study Design: Evaluation of both galectin-3 and glypican-3
expression using standard immunohistochemical techniques.
Statistical Analysis Used: Descriptive analysis of the variables
and statistical significances were calculated by non-parametric
chi-square test using the Statistical Package for the Social
Sciences version 12.0 (SPSS).
Results: Five (30%) and 4 (24%) out of the 17 studied follicular
adenoma cases, were positively stained by galectin-3 and
glypican-3 respectively, while 30 (97%) and 25 (81%) cases
out of the studied 31 carcinoma cases were positively stained
by galectin-3 and glypican-3 respectively. The sensitivity,
specificity and diagnostic accuracy of galectin-3 vs. glypican-3
in discrimination between thyroid carcinoma and adenoma was
96.8%, 70.6%, and 87.5%vs. 81% 76.5% and 79% respectively.
As for the discrimination between follicular-patterned thyroid
carcinoma and follicular adenoma it was 90%, 71% and 78%
vs. 90% 76.5% and 82%.
Conclusion: Glypican-3 is more specific while galectin-3 is
more sensitive in diagnosing thyroid carcinoma while glypican-3
is more specific than galectin-3 in discriminating follicularpatterned neoplasm. |
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| ISSN: | 2249-782X 0973-709X |