Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages
Ongoing with current combinations of antiretroviral drugs for the treatment of Human Immunodeficiency Virus (HIV) infection can successfully maintain long-term suppression of HIV-1 replication in plasma. Still, none of these therapies is capable of extinguishing the virus from the long-lived cellula...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-12-01
|
| Series: | Virulence |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21505594.2020.1760443 |
| _version_ | 1819103456944717824 |
|---|---|
| author | Stefano Aquaro Ana Borrajo Michele Pellegrino Valentina Svicher |
| author_facet | Stefano Aquaro Ana Borrajo Michele Pellegrino Valentina Svicher |
| author_sort | Stefano Aquaro |
| collection | DOAJ |
| description | Ongoing with current combinations of antiretroviral drugs for the treatment of Human Immunodeficiency Virus (HIV) infection can successfully maintain long-term suppression of HIV-1 replication in plasma. Still, none of these therapies is capable of extinguishing the virus from the long-lived cellular reservoir, including monocyte-derived macrophages (MDM), that means the principal obstacle to HIV cure. MDM are widely distributed in all tissues and organs, including central system nervous (CNS) where they represent the most frequent HIV-infected cells that means the principal obstacle to HIV cure. Current FDA-approved antiretroviral drugs target viral reverse transcriptase, protease, integrase, and entry processes (coreceptor or fusion blockade). It is desirable to continue to develop new antiretrovirals directed against alternative targets in the virus lifecycle in order to further optimize therapeutic options, overcome resistance to existing medications, and potentially contribute to the elimination of viral reservoirs. This review provides a comprehensive overview of the activity of antiretroviral drugs (classical and upcoming) in monocytes-derived macrophages (MDM). Defining the antiviral activity of these drugs in this important cellular HIV-1 reservoir provides crucial hints about their efficacy in HIV-1 infected patients. |
| first_indexed | 2024-12-22T01:50:45Z |
| format | Article |
| id | doaj.art-2e3d473fcd324eb4a90cd7850e8684d0 |
| institution | Directory Open Access Journal |
| issn | 2150-5594 2150-5608 |
| language | English |
| last_indexed | 2024-12-22T01:50:45Z |
| publishDate | 2020-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj.art-2e3d473fcd324eb4a90cd7850e8684d02022-12-21T18:42:55ZengTaylor & Francis GroupVirulence2150-55942150-56082020-12-0111140041310.1080/21505594.2020.17604431760443Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophagesStefano Aquaro0Ana Borrajo1Michele Pellegrino2Valentina Svicher3Health and Nutritional Sciences, University of CalabriaUniversity of Rome Tor VergataHealth and Nutritional Sciences, University of CalabriaUniversity of Rome Tor VergataOngoing with current combinations of antiretroviral drugs for the treatment of Human Immunodeficiency Virus (HIV) infection can successfully maintain long-term suppression of HIV-1 replication in plasma. Still, none of these therapies is capable of extinguishing the virus from the long-lived cellular reservoir, including monocyte-derived macrophages (MDM), that means the principal obstacle to HIV cure. MDM are widely distributed in all tissues and organs, including central system nervous (CNS) where they represent the most frequent HIV-infected cells that means the principal obstacle to HIV cure. Current FDA-approved antiretroviral drugs target viral reverse transcriptase, protease, integrase, and entry processes (coreceptor or fusion blockade). It is desirable to continue to develop new antiretrovirals directed against alternative targets in the virus lifecycle in order to further optimize therapeutic options, overcome resistance to existing medications, and potentially contribute to the elimination of viral reservoirs. This review provides a comprehensive overview of the activity of antiretroviral drugs (classical and upcoming) in monocytes-derived macrophages (MDM). Defining the antiviral activity of these drugs in this important cellular HIV-1 reservoir provides crucial hints about their efficacy in HIV-1 infected patients.http://dx.doi.org/10.1080/21505594.2020.1760443hiv-1macrophagesvirus reservoirantiretroviral drugs target |
| spellingShingle | Stefano Aquaro Ana Borrajo Michele Pellegrino Valentina Svicher Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages Virulence hiv-1 macrophages virus reservoir antiretroviral drugs target |
| title | Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages |
| title_full | Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages |
| title_fullStr | Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages |
| title_full_unstemmed | Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages |
| title_short | Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages |
| title_sort | mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages |
| topic | hiv-1 macrophages virus reservoir antiretroviral drugs target |
| url | http://dx.doi.org/10.1080/21505594.2020.1760443 |
| work_keys_str_mv | AT stefanoaquaro mechanismsunderlyingofantiretroviraldrugsindifferentcellularreservoirswithafocusonmacrophages AT anaborrajo mechanismsunderlyingofantiretroviraldrugsindifferentcellularreservoirswithafocusonmacrophages AT michelepellegrino mechanismsunderlyingofantiretroviraldrugsindifferentcellularreservoirswithafocusonmacrophages AT valentinasvicher mechanismsunderlyingofantiretroviraldrugsindifferentcellularreservoirswithafocusonmacrophages |