Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications
Abstract Nanotechnology-based therapeutic approaches have attracted attention of scientists, in particular due to the special features of nanomaterials, such as adequate biocompatibility, ability to improve therapeutic efficiency of incorporated drugs and to limit their adverse effects. Among a vari...
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-019-0566-z |
| _version_ | 1811186532198907904 |
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| author | Urszula Wnorowska Krzysztof Fiedoruk Ewelina Piktel Suhanya V. Prasad Magdalena Sulik Marianna Janion Tamara Daniluk Paul B. Savage Robert Bucki |
| author_facet | Urszula Wnorowska Krzysztof Fiedoruk Ewelina Piktel Suhanya V. Prasad Magdalena Sulik Marianna Janion Tamara Daniluk Paul B. Savage Robert Bucki |
| author_sort | Urszula Wnorowska |
| collection | DOAJ |
| description | Abstract Nanotechnology-based therapeutic approaches have attracted attention of scientists, in particular due to the special features of nanomaterials, such as adequate biocompatibility, ability to improve therapeutic efficiency of incorporated drugs and to limit their adverse effects. Among a variety of reported nanomaterials for biomedical applications, metal and metal oxide-based nanoparticles offer unique physicochemical properties allowing their use in combination with conventional antimicrobials and as magnetic field-controlled drug delivery nanocarriers. An ever-growing number of studies demonstrate that by combining magnetic nanoparticles with membrane-active, natural human cathelicidin-derived LL-37 peptide, and its synthetic mimics such as ceragenins, innovative nanoagents might be developed. Between others, they demonstrate high clinical potential as antimicrobial, anti-cancer, immunomodulatory and regenerative agents. Due to continuous research, knowledge on pleiotropic character of natural antibacterial peptides and their mimics is growing, and it is justifying to stay that the therapeutic potential of nanosystems containing membrane active compounds has not been exhausted yet. |
| first_indexed | 2024-04-11T13:48:09Z |
| format | Article |
| id | doaj.art-2e3f920a52db4bd5aeb977d1a971c069 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T13:48:09Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-2e3f920a52db4bd5aeb977d1a971c0692022-12-22T04:20:53ZengBMCJournal of Nanobiotechnology1477-31552020-01-0118111810.1186/s12951-019-0566-zNanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applicationsUrszula Wnorowska0Krzysztof Fiedoruk1Ewelina Piktel2Suhanya V. Prasad3Magdalena Sulik4Marianna Janion5Tamara Daniluk6Paul B. Savage7Robert Bucki8Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of BiałystokDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of BiałystokDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of BiałystokDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of BiałystokDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of BiałystokFaculty of Medicine and Health Sciences, The Jan Kochanowski University in KielceDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of BiałystokDepartment of Chemistry and Biochemistry, Brigham Young UniversityDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of BiałystokAbstract Nanotechnology-based therapeutic approaches have attracted attention of scientists, in particular due to the special features of nanomaterials, such as adequate biocompatibility, ability to improve therapeutic efficiency of incorporated drugs and to limit their adverse effects. Among a variety of reported nanomaterials for biomedical applications, metal and metal oxide-based nanoparticles offer unique physicochemical properties allowing their use in combination with conventional antimicrobials and as magnetic field-controlled drug delivery nanocarriers. An ever-growing number of studies demonstrate that by combining magnetic nanoparticles with membrane-active, natural human cathelicidin-derived LL-37 peptide, and its synthetic mimics such as ceragenins, innovative nanoagents might be developed. Between others, they demonstrate high clinical potential as antimicrobial, anti-cancer, immunomodulatory and regenerative agents. Due to continuous research, knowledge on pleiotropic character of natural antibacterial peptides and their mimics is growing, and it is justifying to stay that the therapeutic potential of nanosystems containing membrane active compounds has not been exhausted yet.https://doi.org/10.1186/s12951-019-0566-zNanotechnologyNanomedicineNanoantibioticsHuman cathelicidinLL-37 peptideCeragenins |
| spellingShingle | Urszula Wnorowska Krzysztof Fiedoruk Ewelina Piktel Suhanya V. Prasad Magdalena Sulik Marianna Janion Tamara Daniluk Paul B. Savage Robert Bucki Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications Journal of Nanobiotechnology Nanotechnology Nanomedicine Nanoantibiotics Human cathelicidin LL-37 peptide Ceragenins |
| title | Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications |
| title_full | Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications |
| title_fullStr | Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications |
| title_full_unstemmed | Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications |
| title_short | Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications |
| title_sort | nanoantibiotics containing membrane active human cathelicidin ll 37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools current status and potential future applications |
| topic | Nanotechnology Nanomedicine Nanoantibiotics Human cathelicidin LL-37 peptide Ceragenins |
| url | https://doi.org/10.1186/s12951-019-0566-z |
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