New approaches to immunotherapy in house dust mite allergy
Allergen immunotherapy (AIT) has developed over the last few decades and has emerged as a promising treatment. House dust mite (HDM) is a target allergen in AIT, and various modified HDM allergens have been improved for their efficacy. Moreover, clinical trials have proved their significantly therap...
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| Format: | Article |
| Language: | English |
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The Korean Pediatric Society
2023-04-01
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| Series: | Clinical and Experimental Pediatrics |
| Subjects: | |
| Online Access: | http://e-cep.org/upload/pdf/cep-2022-00479.pdf |
| _version_ | 1797844244018233344 |
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| author | In Sik Kim |
| author_facet | In Sik Kim |
| author_sort | In Sik Kim |
| collection | DOAJ |
| description | Allergen immunotherapy (AIT) has developed over the last few decades and has emerged as a promising treatment. House dust mite (HDM) is a target allergen in AIT, and various modified HDM allergens have been improved for their efficacy. Moreover, clinical trials have proved their significantly therapeutic effects in allergy. This article review focuses on HDM allergens developed for AIT efficacy, and determines that their action mechanisms are strongly based on immune tolerance. Treatments for HDM allergens have been optimized by modification or/and addition of adjuvants, and clinically evaluated by subcutaneous and sublingual administration. Representative allergens used in AIT are chemically modified allergoids and recombinant allergens, including altered epitopes. The effective mechanisms subsequent to AIT include the suppressive actions of interleukin-10 and transforming growth factor-β secreted by regulatory cells, including regulatory T cells and regulatory B cells, and isotype switching from immunoglobulin E to immunoglobulin G4. Further studies of AIT are needed to achieve the milestone in treating allergies. |
| first_indexed | 2024-04-09T17:19:10Z |
| format | Article |
| id | doaj.art-2e42276b2c064bf8ad054c48eccb1f83 |
| institution | Directory Open Access Journal |
| issn | 2713-4148 |
| language | English |
| last_indexed | 2024-04-09T17:19:10Z |
| publishDate | 2023-04-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj.art-2e42276b2c064bf8ad054c48eccb1f832023-04-19T04:31:58ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482023-04-0166416116810.3345/cep.2022.0047920125555563New approaches to immunotherapy in house dust mite allergyIn Sik KimAllergen immunotherapy (AIT) has developed over the last few decades and has emerged as a promising treatment. House dust mite (HDM) is a target allergen in AIT, and various modified HDM allergens have been improved for their efficacy. Moreover, clinical trials have proved their significantly therapeutic effects in allergy. This article review focuses on HDM allergens developed for AIT efficacy, and determines that their action mechanisms are strongly based on immune tolerance. Treatments for HDM allergens have been optimized by modification or/and addition of adjuvants, and clinically evaluated by subcutaneous and sublingual administration. Representative allergens used in AIT are chemically modified allergoids and recombinant allergens, including altered epitopes. The effective mechanisms subsequent to AIT include the suppressive actions of interleukin-10 and transforming growth factor-β secreted by regulatory cells, including regulatory T cells and regulatory B cells, and isotype switching from immunoglobulin E to immunoglobulin G4. Further studies of AIT are needed to achieve the milestone in treating allergies.http://e-cep.org/upload/pdf/cep-2022-00479.pdfallergen immunotherapyhouse dust miteallergy |
| spellingShingle | In Sik Kim New approaches to immunotherapy in house dust mite allergy Clinical and Experimental Pediatrics allergen immunotherapy house dust mite allergy |
| title | New approaches to immunotherapy in house dust mite allergy |
| title_full | New approaches to immunotherapy in house dust mite allergy |
| title_fullStr | New approaches to immunotherapy in house dust mite allergy |
| title_full_unstemmed | New approaches to immunotherapy in house dust mite allergy |
| title_short | New approaches to immunotherapy in house dust mite allergy |
| title_sort | new approaches to immunotherapy in house dust mite allergy |
| topic | allergen immunotherapy house dust mite allergy |
| url | http://e-cep.org/upload/pdf/cep-2022-00479.pdf |
| work_keys_str_mv | AT insikkim newapproachestoimmunotherapyinhousedustmiteallergy |