Alterations of Static and Dynamic Functional Connectivity of the Nucleus Accumbens in Patients With Major Depressive Disorder
BackgroundMajor depressive disorder (MDD) is associated with dysfunction of the reward system. As an important node in the reward system, the resting-state functional connectivity of the nucleus accumbens (NAc) is related to the etiology of MDD. However, an increasing number of recent studies propos...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.877417/full |
| _version_ | 1817982797334183936 |
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| author | Bingqian Zhou Yuan Chen Ruiping Zheng Yu Jiang Shuying Li Yarui Wei MengZhe Zhang XinYu Gao Baohong Wen Shaoqiang Han Jingliang Cheng |
| author_facet | Bingqian Zhou Yuan Chen Ruiping Zheng Yu Jiang Shuying Li Yarui Wei MengZhe Zhang XinYu Gao Baohong Wen Shaoqiang Han Jingliang Cheng |
| author_sort | Bingqian Zhou |
| collection | DOAJ |
| description | BackgroundMajor depressive disorder (MDD) is associated with dysfunction of the reward system. As an important node in the reward system, the resting-state functional connectivity of the nucleus accumbens (NAc) is related to the etiology of MDD. However, an increasing number of recent studies propose that brain activity is dynamic over time, no study to date has examined whether the NAc dynamic functional connectivity (DFC) is changed in patients with MDD. Moreover, few studies have examined the impact of the clinical characteristics of patients with MDD.MethodsA total of 220 MDD patients and 159 healthy controls (HCs), group-matched for age, sex, and education level, underwent resting-state functional magnetic resonance imagining (rs-fMRI) scans. Seed-based resting-state functional connectivity (RSFC) and DFC of the NAc were conducted. Two sample t-tests were performed to alter RSFC/DFC of NAc. In addition, we examined the association between altered RSFC/DFC and depressive severity using Pearson correlation. Finally, we divided patients with MDD into different subgroups according to clinical characteristics and tested whether there were differences between the subgroups.ResultsCompared with the HCs, MDD patients show reduced the NAc-based RSFC with the dorsolateral prefrontal cortex (DLPFC), hippocampus, middle temporal gyrus (MTG), inferior temporal gyrus (ITG), precuneus, and insula, and patients with MDD show reduced the NAc-based DFC with the DLPFC, ventromedial prefrontal cortex (VMPFC), ventrolateral prefrontal cortex (VLPFC), MTG, ITG, and insula. MDD severity was associated with RSFC between the NAc and precentral gyrus (r = 0.288, p = 0.002, uncorrected) and insula (r = 0.272, p = 0.003, uncorrected).ConclusionThis study demonstrates abnormal RSFC and DFC between the NAc and distributed cerebral regions in MDD patients, characterized by decreased RSFC and DFC of the NAc connecting with the reward, executive, default-mode, and salience network. Our results expand previous descriptions of the NAc RSFC abnormalities in MDD, and the altered RSFC/DFC may reflect the disrupted function of the NAc. |
| first_indexed | 2024-04-13T23:24:59Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-04-13T23:24:59Z |
| publishDate | 2022-05-01 |
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| spelling | doaj.art-2e45989c001544a1bfb3ce7f76db50812022-12-22T02:25:05ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-05-011310.3389/fpsyt.2022.877417877417Alterations of Static and Dynamic Functional Connectivity of the Nucleus Accumbens in Patients With Major Depressive DisorderBingqian Zhou0Yuan Chen1Ruiping Zheng2Yu Jiang3Shuying Li4Yarui Wei5MengZhe Zhang6XinYu Gao7Baohong Wen8Shaoqiang Han9Jingliang Cheng10Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaBackgroundMajor depressive disorder (MDD) is associated with dysfunction of the reward system. As an important node in the reward system, the resting-state functional connectivity of the nucleus accumbens (NAc) is related to the etiology of MDD. However, an increasing number of recent studies propose that brain activity is dynamic over time, no study to date has examined whether the NAc dynamic functional connectivity (DFC) is changed in patients with MDD. Moreover, few studies have examined the impact of the clinical characteristics of patients with MDD.MethodsA total of 220 MDD patients and 159 healthy controls (HCs), group-matched for age, sex, and education level, underwent resting-state functional magnetic resonance imagining (rs-fMRI) scans. Seed-based resting-state functional connectivity (RSFC) and DFC of the NAc were conducted. Two sample t-tests were performed to alter RSFC/DFC of NAc. In addition, we examined the association between altered RSFC/DFC and depressive severity using Pearson correlation. Finally, we divided patients with MDD into different subgroups according to clinical characteristics and tested whether there were differences between the subgroups.ResultsCompared with the HCs, MDD patients show reduced the NAc-based RSFC with the dorsolateral prefrontal cortex (DLPFC), hippocampus, middle temporal gyrus (MTG), inferior temporal gyrus (ITG), precuneus, and insula, and patients with MDD show reduced the NAc-based DFC with the DLPFC, ventromedial prefrontal cortex (VMPFC), ventrolateral prefrontal cortex (VLPFC), MTG, ITG, and insula. MDD severity was associated with RSFC between the NAc and precentral gyrus (r = 0.288, p = 0.002, uncorrected) and insula (r = 0.272, p = 0.003, uncorrected).ConclusionThis study demonstrates abnormal RSFC and DFC between the NAc and distributed cerebral regions in MDD patients, characterized by decreased RSFC and DFC of the NAc connecting with the reward, executive, default-mode, and salience network. Our results expand previous descriptions of the NAc RSFC abnormalities in MDD, and the altered RSFC/DFC may reflect the disrupted function of the NAc.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.877417/fullmajor depressive disorderresting-state functional connectivitydynamic functional connectivitynucleus accumbensreward |
| spellingShingle | Bingqian Zhou Yuan Chen Ruiping Zheng Yu Jiang Shuying Li Yarui Wei MengZhe Zhang XinYu Gao Baohong Wen Shaoqiang Han Jingliang Cheng Alterations of Static and Dynamic Functional Connectivity of the Nucleus Accumbens in Patients With Major Depressive Disorder Frontiers in Psychiatry major depressive disorder resting-state functional connectivity dynamic functional connectivity nucleus accumbens reward |
| title | Alterations of Static and Dynamic Functional Connectivity of the Nucleus Accumbens in Patients With Major Depressive Disorder |
| title_full | Alterations of Static and Dynamic Functional Connectivity of the Nucleus Accumbens in Patients With Major Depressive Disorder |
| title_fullStr | Alterations of Static and Dynamic Functional Connectivity of the Nucleus Accumbens in Patients With Major Depressive Disorder |
| title_full_unstemmed | Alterations of Static and Dynamic Functional Connectivity of the Nucleus Accumbens in Patients With Major Depressive Disorder |
| title_short | Alterations of Static and Dynamic Functional Connectivity of the Nucleus Accumbens in Patients With Major Depressive Disorder |
| title_sort | alterations of static and dynamic functional connectivity of the nucleus accumbens in patients with major depressive disorder |
| topic | major depressive disorder resting-state functional connectivity dynamic functional connectivity nucleus accumbens reward |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.877417/full |
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