Activated Natural Killer Cells Withstand the Relatively Low Glucose Concentrations Found in the Bone Marrow of Multiple Myeloma Patients

Activated Natural Killer Cells Withstand the Relatively Low Glucose Concentrations Found in the Bone Marrow of Multiple Myeloma Patients

Infusion of ex vivo expanded and cytokine-activated natural killer (NK) cells is a promising alternative way to treat multiple myeloma (MM). However, the tumor microenvironment (TME) may suppress their function. While reduced glucose availability is a TME hallmark of many solid tumors, glucose level...

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Bibliographic Details
Main Authors: Femke A. I. Ehlers, Niken M. Mahaweni, Timo I. Olieslagers, Gerard M. J. Bos, Lotte Wieten
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
NK cells
multiple myeloma
immunotherapy
tumor microenvironment
glucose
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.622896/full

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