Far-field super-resolution chemical microscopy

Abstract Far-field chemical microscopy providing molecular electronic or vibrational fingerprint information opens a new window for the study of three-dimensional biological, material, and chemical systems. Chemical microscopy provides a nondestructive way of chemical identification without exterior...

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Main Authors: Mingwei Tang, Yubing Han, Danchen Jia, Qing Yang, Ji-Xin Cheng
Format: Article
Language:English
Published: Nature Publishing Group 2023-06-01
Series:Light: Science & Applications
Online Access:https://doi.org/10.1038/s41377-023-01182-7
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author Mingwei Tang
Yubing Han
Danchen Jia
Qing Yang
Ji-Xin Cheng
author_facet Mingwei Tang
Yubing Han
Danchen Jia
Qing Yang
Ji-Xin Cheng
author_sort Mingwei Tang
collection DOAJ
description Abstract Far-field chemical microscopy providing molecular electronic or vibrational fingerprint information opens a new window for the study of three-dimensional biological, material, and chemical systems. Chemical microscopy provides a nondestructive way of chemical identification without exterior labels. However, the diffraction limit of optics hindered it from discovering more details under the resolution limit. Recent development of super-resolution techniques gives enlightenment to open this door behind far-field chemical microscopy. Here, we review recent advances that have pushed the boundary of far-field chemical microscopy in terms of spatial resolution. We further highlight applications in biomedical research, material characterization, environmental study, cultural heritage conservation, and integrated chip inspection.
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spelling doaj.art-2e47d169e2c747be9d382d46cde9a5cd2023-06-11T11:25:36ZengNature Publishing GroupLight: Science & Applications2047-75382023-06-0112112210.1038/s41377-023-01182-7Far-field super-resolution chemical microscopyMingwei Tang0Yubing Han1Danchen Jia2Qing Yang3Ji-Xin Cheng4State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang UniversityState Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang UniversityDepartment of Biomedical Engineering, Department of Electrical and Computer Engineering, Photonics Center, Boston UniversityState Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang UniversityDepartment of Biomedical Engineering, Department of Electrical and Computer Engineering, Photonics Center, Boston UniversityAbstract Far-field chemical microscopy providing molecular electronic or vibrational fingerprint information opens a new window for the study of three-dimensional biological, material, and chemical systems. Chemical microscopy provides a nondestructive way of chemical identification without exterior labels. However, the diffraction limit of optics hindered it from discovering more details under the resolution limit. Recent development of super-resolution techniques gives enlightenment to open this door behind far-field chemical microscopy. Here, we review recent advances that have pushed the boundary of far-field chemical microscopy in terms of spatial resolution. We further highlight applications in biomedical research, material characterization, environmental study, cultural heritage conservation, and integrated chip inspection.https://doi.org/10.1038/s41377-023-01182-7
spellingShingle Mingwei Tang
Yubing Han
Danchen Jia
Qing Yang
Ji-Xin Cheng
Far-field super-resolution chemical microscopy
Light: Science & Applications
title Far-field super-resolution chemical microscopy
title_full Far-field super-resolution chemical microscopy
title_fullStr Far-field super-resolution chemical microscopy
title_full_unstemmed Far-field super-resolution chemical microscopy
title_short Far-field super-resolution chemical microscopy
title_sort far field super resolution chemical microscopy
url https://doi.org/10.1038/s41377-023-01182-7
work_keys_str_mv AT mingweitang farfieldsuperresolutionchemicalmicroscopy
AT yubinghan farfieldsuperresolutionchemicalmicroscopy
AT danchenjia farfieldsuperresolutionchemicalmicroscopy
AT qingyang farfieldsuperresolutionchemicalmicroscopy
AT jixincheng farfieldsuperresolutionchemicalmicroscopy