Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions

Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions

Abstract The hippocampus is a plastic brain area that shows functional segregation along its longitudinal axis, reflected by a higher level of long-term potentiation (LTP) in the CA1 region of the dorsal hippocampus (DH) compared to the ventral hippocampus (VH), but the mechanisms underlying this di...

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Bibliographic Details
Main Authors: E. De Felice, E. Gonçalves de Andrade, M. T. Golia, F. González Ibáñez, M. Khakpour, M. A. Di Castro, S. Garofalo, E. Di Pietro, C. Benatti, N. Brunello, F. Tascedda, B. Kaminska, C. Limatola, D. Ragozzino, M. E. Tremblay, S. Alboni, L. Maggi
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Neuroinflammation
Subjects:
LTP
Dorsal hippocampus
Ventral hippocampus
Microglial morphology
Microglial ultrastructure
CX3CL1–CX3CR1 signaling
Online Access:https://doi.org/10.1186/s12974-022-02655-z

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