Role of RNA-binding proteins in both COPD and lung cancer
Chronic obstructive pulmonary disease (COPD) is an independent risk factor for the development of lung cancer. Several pathogenic pathways such as oxidative stress and chronic inflammation of the lower airways are shared by these two diseases. The RNA-binding proteins (RBPs) can modulate the post-tr...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Accademia Peloritana dei Pericolanti
2022-12-01
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| Series: | Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche |
| Subjects: | |
| Online Access: | https://cab.unime.it/journals/index.php/APMB/article/view/3633 |
| _version_ | 1797974607790080000 |
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| author | Francesco Nucera Ilaria Salvato Luca Ricciardi Annunziata Nigro Jessica Dal Col Francesco Monaco Antonio Ieni Guido Fadda Giovanni Tuccari Cristiana Stellato Gaetano Caramori |
| author_facet | Francesco Nucera Ilaria Salvato Luca Ricciardi Annunziata Nigro Jessica Dal Col Francesco Monaco Antonio Ieni Guido Fadda Giovanni Tuccari Cristiana Stellato Gaetano Caramori |
| author_sort | Francesco Nucera |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is an independent risk factor for the development of lung cancer. Several pathogenic pathways such as oxidative stress and chronic inflammation of the lower airways are shared by these two diseases. The RNA-binding proteins (RBPs) can modulate the post-transcriptional expression of genes involved in several biological processes, such as cell cycle, cell proliferation and injury/stress responses. The bonding between RBPs and targeted transcripts regulates mRNA turnover, subcellular localization, splicing and translation, through the formation of ribonucleoproteins (RNPs) complexes. Several pro-inflammatory mediators, that induce and maintain chronic lung inflammation and carcinogenesis, are modulate by RBPs.
RBPs can have a key role in lung cancer onset in COPD patients, sharing several common pathogenic processes, including oxidative stress, inflammation of lower airways, DNA damage and impaired DNA-repair mechanisms.
Further studies are mandatory to clarify the application of RBPs as novel biomarkers and potential therapeutic targets. This review will investigate recent evidences showing the role of RBPs in the pathogenic mechanisms sharing by lung cancer and COPD |
| first_indexed | 2024-04-11T04:22:28Z |
| format | Article |
| id | doaj.art-2e4cb451194e4445bba4c2ab789f6126 |
| institution | Directory Open Access Journal |
| issn | 1828-6550 |
| language | English |
| last_indexed | 2024-04-11T04:22:28Z |
| publishDate | 2022-12-01 |
| publisher | Accademia Peloritana dei Pericolanti |
| record_format | Article |
| series | Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche |
| spelling | doaj.art-2e4cb451194e4445bba4c2ab789f61262022-12-30T11:43:39ZengAccademia Peloritana dei PericolantiAtti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche1828-65502022-12-01110211210.13129/1828-6550/APMB.110.2.2022.SD12871Role of RNA-binding proteins in both COPD and lung cancerFrancesco Nucera0Ilaria Salvato1Luca Ricciardi2Annunziata Nigro3Jessica Dal Col4Francesco Monaco5Antonio Ieni6Guido Fadda7Giovanni Tuccari8Cristiana Stellato9Gaetano Caramori10Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università degli Studi di MessinaPneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università degli Studi di MessinaPneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università degli Studi di MessinaDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, SalernoDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, SalernoChirurgia Toracica, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università degli Studi di MessinaDepartment of Human Pathology of Adult and Developmental Age "Gaetano Barresi", Section of Pathological Anatomy, University of MessinaDepartment of Human Pathology of Adult and Developmental Age "Gaetano Barresi", Section of Pathological Anatomy, University of MessinaDepartment of Human Pathology of Adult and Developmental Age "Gaetano Barresi", Section of Pathological Anatomy, University of MessinaDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of SalernoPneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università degli Studi di MessinaChronic obstructive pulmonary disease (COPD) is an independent risk factor for the development of lung cancer. Several pathogenic pathways such as oxidative stress and chronic inflammation of the lower airways are shared by these two diseases. The RNA-binding proteins (RBPs) can modulate the post-transcriptional expression of genes involved in several biological processes, such as cell cycle, cell proliferation and injury/stress responses. The bonding between RBPs and targeted transcripts regulates mRNA turnover, subcellular localization, splicing and translation, through the formation of ribonucleoproteins (RNPs) complexes. Several pro-inflammatory mediators, that induce and maintain chronic lung inflammation and carcinogenesis, are modulate by RBPs. RBPs can have a key role in lung cancer onset in COPD patients, sharing several common pathogenic processes, including oxidative stress, inflammation of lower airways, DNA damage and impaired DNA-repair mechanisms. Further studies are mandatory to clarify the application of RBPs as novel biomarkers and potential therapeutic targets. This review will investigate recent evidences showing the role of RBPs in the pathogenic mechanisms sharing by lung cancer and COPDhttps://cab.unime.it/journals/index.php/APMB/article/view/3633chronic airway inflammation, copd, lung cancer, post-transcriptional regulation, rna-binding proteins |
| spellingShingle | Francesco Nucera Ilaria Salvato Luca Ricciardi Annunziata Nigro Jessica Dal Col Francesco Monaco Antonio Ieni Guido Fadda Giovanni Tuccari Cristiana Stellato Gaetano Caramori Role of RNA-binding proteins in both COPD and lung cancer Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche chronic airway inflammation, copd, lung cancer, post-transcriptional regulation, rna-binding proteins |
| title | Role of RNA-binding proteins in both COPD and lung cancer |
| title_full | Role of RNA-binding proteins in both COPD and lung cancer |
| title_fullStr | Role of RNA-binding proteins in both COPD and lung cancer |
| title_full_unstemmed | Role of RNA-binding proteins in both COPD and lung cancer |
| title_short | Role of RNA-binding proteins in both COPD and lung cancer |
| title_sort | role of rna binding proteins in both copd and lung cancer |
| topic | chronic airway inflammation, copd, lung cancer, post-transcriptional regulation, rna-binding proteins |
| url | https://cab.unime.it/journals/index.php/APMB/article/view/3633 |
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