Anti-Citrullinated Protein Antibody Titers Are Independently Modulated by Both Disease Activity and Conventional or Biologic Anti-Rheumatic Drugs
This study aimed to analyze the factors that influence anti-citrullinated protein antibody (ACPA) titers in a seropositive early arthritis (EA) population under non-protocolized treatment with disease-modifying anti-rheumatic drugs (DMARDs). A total of 130 ACPA-positive patients from the PEARL (Prin...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/7/1773 |
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| author | Miren Uriarte Ecenarro Daniel Useros Aranzazu Alfranca Reyes Tejedor Isidoro González-Alvaro Rosario García-Vicuña |
| author_facet | Miren Uriarte Ecenarro Daniel Useros Aranzazu Alfranca Reyes Tejedor Isidoro González-Alvaro Rosario García-Vicuña |
| author_sort | Miren Uriarte Ecenarro |
| collection | DOAJ |
| description | This study aimed to analyze the factors that influence anti-citrullinated protein antibody (ACPA) titers in a seropositive early arthritis (EA) population under non-protocolized treatment with disease-modifying anti-rheumatic drugs (DMARDs). A total of 130 ACPA-positive patients from the PEARL (Princesa Early Arthritis Longitudinal) study were studied along a 5-year follow-up. Sociodemographic, clinical, and therapeutic variables, along with serum samples, were collected at five visits by protocol. Anti-cyclic citrullinated peptide 2 (CCP2) ACPA titers were measured by ELISA. The effect of different variables on anti-CCP2 titers was estimated using longitudinal multivariate analysis models, nested by visit and patient. Data from 471 visits in 130 patients were analyzed. A significant decrease in anti-CCP2 titers was observed at all time-points, compared to baseline, following the decline of disease activity. In the multivariate analysis, active or ever smoking was significantly associated with the highest anti-CCP2 titers while reduction in disease activity was associated with titer decline. After adjusting for these variables, both conventional synthetic (cs) and biologic (b) DMARDs accounted for the decline in anti-CCP2 titers as independent factors. Conclusion: In patients with EA, an early and sustained reduction in ACPA titers can be detected associated with the decline in disease activity, irrespective of the treatment used. |
| first_indexed | 2024-03-09T03:30:17Z |
| format | Article |
| id | doaj.art-2e4d4a39d1b84735937434cbca79ce6b |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T03:30:17Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2e4d4a39d1b84735937434cbca79ce6b2023-12-03T14:55:39ZengMDPI AGDiagnostics2075-44182022-07-01127177310.3390/diagnostics12071773Anti-Citrullinated Protein Antibody Titers Are Independently Modulated by Both Disease Activity and Conventional or Biologic Anti-Rheumatic DrugsMiren Uriarte Ecenarro0Daniel Useros1Aranzazu Alfranca2Reyes Tejedor3Isidoro González-Alvaro4Rosario García-Vicuña5Rheumatology Service, Hospital Universitario La Princesa, IIS-Princesa, 28006 Madrid, SpainInternal Medicine Service, Hospital Universitario La Princesa, IIS-Princesa, 28006 Madrid, SpainImmunology Service, Hospital Universitario La Princesa, IIS-Princesa, 28006 Madrid, SpainImmunology Service, Hospital Universitario La Princesa, IIS-Princesa, 28006 Madrid, SpainRheumatology Service, Hospital Universitario La Princesa, IIS-Princesa, 28006 Madrid, SpainRheumatology Service, Hospital Universitario La Princesa, IIS-Princesa, 28006 Madrid, SpainThis study aimed to analyze the factors that influence anti-citrullinated protein antibody (ACPA) titers in a seropositive early arthritis (EA) population under non-protocolized treatment with disease-modifying anti-rheumatic drugs (DMARDs). A total of 130 ACPA-positive patients from the PEARL (Princesa Early Arthritis Longitudinal) study were studied along a 5-year follow-up. Sociodemographic, clinical, and therapeutic variables, along with serum samples, were collected at five visits by protocol. Anti-cyclic citrullinated peptide 2 (CCP2) ACPA titers were measured by ELISA. The effect of different variables on anti-CCP2 titers was estimated using longitudinal multivariate analysis models, nested by visit and patient. Data from 471 visits in 130 patients were analyzed. A significant decrease in anti-CCP2 titers was observed at all time-points, compared to baseline, following the decline of disease activity. In the multivariate analysis, active or ever smoking was significantly associated with the highest anti-CCP2 titers while reduction in disease activity was associated with titer decline. After adjusting for these variables, both conventional synthetic (cs) and biologic (b) DMARDs accounted for the decline in anti-CCP2 titers as independent factors. Conclusion: In patients with EA, an early and sustained reduction in ACPA titers can be detected associated with the decline in disease activity, irrespective of the treatment used.https://www.mdpi.com/2075-4418/12/7/1773early arthritisRheumatoid arthritisACPAbiomarkersdisease activitydisease-modifying anti-rheumatic drugs (DMARDs) |
| spellingShingle | Miren Uriarte Ecenarro Daniel Useros Aranzazu Alfranca Reyes Tejedor Isidoro González-Alvaro Rosario García-Vicuña Anti-Citrullinated Protein Antibody Titers Are Independently Modulated by Both Disease Activity and Conventional or Biologic Anti-Rheumatic Drugs Diagnostics early arthritis Rheumatoid arthritis ACPA biomarkers disease activity disease-modifying anti-rheumatic drugs (DMARDs) |
| title | Anti-Citrullinated Protein Antibody Titers Are Independently Modulated by Both Disease Activity and Conventional or Biologic Anti-Rheumatic Drugs |
| title_full | Anti-Citrullinated Protein Antibody Titers Are Independently Modulated by Both Disease Activity and Conventional or Biologic Anti-Rheumatic Drugs |
| title_fullStr | Anti-Citrullinated Protein Antibody Titers Are Independently Modulated by Both Disease Activity and Conventional or Biologic Anti-Rheumatic Drugs |
| title_full_unstemmed | Anti-Citrullinated Protein Antibody Titers Are Independently Modulated by Both Disease Activity and Conventional or Biologic Anti-Rheumatic Drugs |
| title_short | Anti-Citrullinated Protein Antibody Titers Are Independently Modulated by Both Disease Activity and Conventional or Biologic Anti-Rheumatic Drugs |
| title_sort | anti citrullinated protein antibody titers are independently modulated by both disease activity and conventional or biologic anti rheumatic drugs |
| topic | early arthritis Rheumatoid arthritis ACPA biomarkers disease activity disease-modifying anti-rheumatic drugs (DMARDs) |
| url | https://www.mdpi.com/2075-4418/12/7/1773 |
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