Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis

Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis

WIN-55,212-2 (WIN-2) can elicit anti-inflammatory and cognitive-enhancing effect in aged rats. The current study was designed to determine the differential role of the endocannabinoid receptor sub-types 1 (CB1) and 2 (CB2) and transient receptor potential vanilloid 1 receptor (TRPV1) in the reductio...

Full description

Bibliographic Details
Main Authors:	Yannick Marchalant, Holly M. Brothers, Greg J. Norman, Kate Karelina, A. Courtney DeVries, Gary L. Wenk
Format:	Article
Language:	English
Published:	Elsevier 2009-05-01
Series:	Neurobiology of Disease
Subjects:	Cannabinoid receptors Vanilloid receptors Neurogenesis Neuroinflammation Microglia Aging
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996109000254

Similar Items

Can the benefits of cannabinoid receptor stimulation on neuroinflammation, neurogenesis and memory during normal aging be useful in AD prevention?
by: Marchalant Yannick, et al.
Published: (2012-01-01)

Cannabinoids and Neurogenesis: The Promised Solution for Neurodegeneration?
by: Andrea Valeri, et al.
Published: (2021-10-01)

Activation of Cannabinoid Type 2 Receptor in Microglia Reduces Neuroinflammation through Inhibiting Aerobic Glycolysis to Relieve Hypertension
by: Ruohan Shan, et al.
Published: (2024-03-01)

Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System
by: Sumit S. Rathod, et al.
Published: (2023-09-01)

Interaction between Cannabinoid Type 1 and Type 2 Receptors in the Modulation of Subventricular Zone and Dentate Gyrus Neurogenesis
by: Rui S. Rodrigues, et al.
Published: (2017-08-01)

Microglia-induced neuroinflammation in hippocampal neurogenesis following traumatic brain injury
by: Seyedeh Parisa Navabi, et al.
Published: (2024-08-01)

Cannabinoids and neuroinflammation: Therapeutic implications
by: Brian E. Leonard, et al.
Published: (2023-04-01)

Cannabinoid type 2 receptor deficiency leads to Aβ-induced cognitive impairment through promoting microglial sensitivity to Aβ in the prefrontal cortex in mice
by: Tong Zhang, et al.
Published: (2024-12-01)

In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study
by: Teruyo Hosoya, et al.
Published: (2017-03-01)

Brain-Derived Neurotrophic Factor (BDNF) Role in Cannabinoid-Mediated Neurogenesis
by: Filipa Fiel Ferreira, et al.
Published: (2018-11-01)

Spinal cannabinoid receptor 2 activation alleviates neuropathic pain by regulating microglia and suppressing P2X7 receptor
by: Yifan Zhou, et al.
Published: (2023-03-01)

Cellular Distribution of Canonical and Putative Cannabinoid Receptors in Canine Cervical Dorsal Root Ganglia
by: Roberto Chiocchetti, et al.
Published: (2019-09-01)

Corrigendum: Cellular Distribution of Canonical and Putative Cannabinoid Receptors in Canine Cervical Dorsal Root Ganglia
by: Roberto Chiocchetti, et al.
Published: (2019-10-01)

Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy
by: Valerie Joers, et al.
Published: (2024-09-01)

Shifting equilibriums in Alzheimer’s disease: the complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis
by: Sophie C Gray, et al.
Published: (2020-01-01)

Microglial Phenotypes and Their Relationship to the Cannabinoid System: Therapeutic Implications for Parkinson’s Disease
by: Rachel Kelly, et al.
Published: (2020-01-01)

Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation
by: Andro Montoya, et al.
Published: (2019-12-01)

Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer’s disease
by: Alicia López, et al.
Published: (2018-05-01)

CB2 expression in mouse brain: from mapping to regulation in microglia under inflammatory conditions
by: Wanda Grabon, et al.
Published: (2024-08-01)

Pharmacological blockade of either, cannabinoid CB1 or CB2 receptors, prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rats.
by: EDUARDO eBLANCO-CALVO, et al.
Published: (2014-01-01)

Glial PAMPering and DAMPening of Adult Hippocampal Neurogenesis
by: Luke Parkitny, et al.
Published: (2021-09-01)

Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury
by: Fan Jiang, et al.
Published: (2022-09-01)

Plasmalogens Eliminate Aging-Associated Synaptic Defects and Microglia-Mediated Neuroinflammation in Mice
by: Jinxin Gu, et al.
Published: (2022-02-01)

Dysregulation of neurogenesis by neuroinflammation: key differences in neurodevelopmental and neurological disorders
by: Lir-Wan Fan, et al.
Published: (2017-01-01)

The effect of cannabinoid type 2 receptor agonist on morphine tolerance
by: Di Cui, et al.
Published: (2024-06-01)

Cerebral Glutamate Regulation and Receptor Changes in Perioperative Neuroinflammation and Cognitive Dysfunction
by: Yan Zhang, et al.
Published: (2022-04-01)

Modulating Neuroinflammation as a Prospective Therapeutic Target in Alzheimer’s Disease
by: Eunshil Lee, et al.
Published: (2025-01-01)

Cannabinoid CB2 receptors and spinal microglia are implicated in tingenone-mediated antinociception in mice
by: Clarice C.V. Moura, et al.
Published: (2021-01-01)

Regulation of the p75 neurotrophin receptor attenuates neuroinflammation and stimulates hippocampal neurogenesis in experimental Streptococcus pneumoniae meningitis
by: Dandan Zhang, et al.
Published: (2021-11-01)

Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer’s Disease
by: Samuel Ruiz de Martín Esteban, et al.
Published: (2022-04-01)

Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors
by: Yiping Cao, et al.
Published: (2024-12-01)

Blockade of Cannabinoid CB1 Receptors in the Dorsal Periaqueductal Gray Unmasks the Antinociceptive Effect of Local Injections of Anandamide in Mice
by: Diego C. Mascarenhas, et al.
Published: (2017-10-01)

The use of cannabinoids in epilepsy as an example: medical, social, and legal aspects
by: R. G. Akzhigitov, et al.
Published: (2020-08-01)

Activation of cannabinoid receptor type 2 attenuates surgery-induced cognitive impairment in mice through anti-inflammatory activity
by: Lingling Sun, et al.
Published: (2017-07-01)

Time course of neuroinflammation after human stroke – a pilot study using co-registered PET and MRI
by: Lucio D’Anna, et al.
Published: (2023-05-01)

The potential of hydrogels as a niche for promoting neurogenesis and regulating neuroinflammation in ischemic stroke
by: Shenzhong Jiang, et al.
Published: (2023-05-01)

Editorial: Cannabinoids in neuroinflammation, neurodegeneration and pain: Focus on non-neuronal cells
by: Haley A. Vecchiarelli, et al.
Published: (2022-12-01)

Therapeutic Potential of Cannabinoids in Glaucoma – Hit or Myth? - A Review
by: Julia Górny, et al.
Published: (2024-11-01)

Evaluation of cannabinoid type 2 receptor expression and pyridine-based radiotracers in brains from a mouse model of Alzheimer’s disease
by: Vasil Kecheliev, et al.
Published: (2022-09-01)

Cannabinoid Receptor 1 Agonist ACEA and Cannabinoid Receptor 2 Agonist GW833972A Attenuates Cell-Mediated Immunity by Different Biological Mechanisms
by: Nuchjira Takheaw, et al.
Published: (2023-03-01)