The Effect of Hydroalcoholic Extract of Glycyrrhizaglabra L. (licorice) Root on Serum Level of Glucose, Triglyceride and Cholesterol in Polycystic Ovary Syndrome Induced by Letrozole in Rats
Background & aim: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder which effects 15.6 % of women in Iran. Licorice (Glycyrrhizaglabra L.) has phytoestrogenic and anti-diabetic effects. The aim of this study was to investigate the effects of hydro-alcoholic Licoric...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
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Yasuj University Of Medical Sciences
2016-05-01
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| Series: | Armaghane Danesh Bimonthly Journal |
| Subjects: | |
| Online Access: | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-486-1&slc_lang=en&sid=1 |
| _version_ | 1797998156683673600 |
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| author | F Barazesh A Mirzaei Z Abbasian M Ghavami Zadeh |
| author_facet | F Barazesh A Mirzaei Z Abbasian M Ghavami Zadeh |
| author_sort | F Barazesh |
| collection | DOAJ |
| description | Background & aim: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder which effects 15.6 % of women in Iran. Licorice (Glycyrrhizaglabra L.) has phytoestrogenic and anti-diabetic effects. The aim of this study was to investigate the effects of hydro-alcoholic Licorice root extract on blood sugar, triglycerides and cholesterol in the rats with PCOS.
Methods: In the present experimental study, 50 female puber Sprague dawley (180±20 gr) rats with regular sexual cycle were entered in the study. Studied groups included: first, the Normal group, receiving carrier (normal saline) (2 ml/kg) daily orally for 21 days. Then, the letrozole group which received letrozole (1 mg/kg) dissolved in normal saline (2 ml/kg) for 21 days and then normal saline (2 ml/kg) daily orally for 30 days. The last groups, Treatment groups 1 and 2, which received letrozole (1 mg/kg) dissolved in normal saline (2 ml/kg) for 21 days then hydroalcoholic extract of Licorice root (200 and 400 mg/kg) dissolved in normal saline (2 ml/kg) daily, orally for 30 days respectively. To conclude, blood samples were collected from the heart and also the serum level of blood sugar, triglyceride and cholesterol was measured. The data were analyzed using one-way ANOVA (p< 0.05).
Results: The mean serum level of blood sugar increased in the Letrozole group compared to the normal group and decreased in the treatment groups compared to Letrozole group (p< 0.05). No statistically significant differences were seen in mean of serum level of triglyceride and cholesterol between all groups.
Conclusion: The licoricecan extract improved the adverse side-effects caused by diabetese in polycystic ovary syndrome However, its effect on dyslipidemia in patients requiring further investigations. |
| first_indexed | 2024-04-11T10:44:08Z |
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| id | doaj.art-2e4f8bfa72f14739a8484580e1d32f9e |
| institution | Directory Open Access Journal |
| issn | 1728-6506 1728-6514 |
| language | fas |
| last_indexed | 2024-04-11T10:44:08Z |
| publishDate | 2016-05-01 |
| publisher | Yasuj University Of Medical Sciences |
| record_format | Article |
| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-2e4f8bfa72f14739a8484580e1d32f9e2022-12-22T04:29:06ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65061728-65142016-05-01212148159The Effect of Hydroalcoholic Extract of Glycyrrhizaglabra L. (licorice) Root on Serum Level of Glucose, Triglyceride and Cholesterol in Polycystic Ovary Syndrome Induced by Letrozole in RatsF Barazesh0A Mirzaei1Z Abbasian2M Ghavami Zadeh3 Student Research Committee, Yasuj University Medical Science, Yasuj, Iran, Medicinal Plant Research Center, Yasuj University Medical Science, Yasuj, Iran Student Research Committee, Yasuj University Medical Science, Yasuj, Iran, Student Research Committee, Yasuj University Medical Science, Yasuj, Iran, Background & aim: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder which effects 15.6 % of women in Iran. Licorice (Glycyrrhizaglabra L.) has phytoestrogenic and anti-diabetic effects. The aim of this study was to investigate the effects of hydro-alcoholic Licorice root extract on blood sugar, triglycerides and cholesterol in the rats with PCOS. Methods: In the present experimental study, 50 female puber Sprague dawley (180±20 gr) rats with regular sexual cycle were entered in the study. Studied groups included: first, the Normal group, receiving carrier (normal saline) (2 ml/kg) daily orally for 21 days. Then, the letrozole group which received letrozole (1 mg/kg) dissolved in normal saline (2 ml/kg) for 21 days and then normal saline (2 ml/kg) daily orally for 30 days. The last groups, Treatment groups 1 and 2, which received letrozole (1 mg/kg) dissolved in normal saline (2 ml/kg) for 21 days then hydroalcoholic extract of Licorice root (200 and 400 mg/kg) dissolved in normal saline (2 ml/kg) daily, orally for 30 days respectively. To conclude, blood samples were collected from the heart and also the serum level of blood sugar, triglyceride and cholesterol was measured. The data were analyzed using one-way ANOVA (p< 0.05). Results: The mean serum level of blood sugar increased in the Letrozole group compared to the normal group and decreased in the treatment groups compared to Letrozole group (p< 0.05). No statistically significant differences were seen in mean of serum level of triglyceride and cholesterol between all groups. Conclusion: The licoricecan extract improved the adverse side-effects caused by diabetese in polycystic ovary syndrome However, its effect on dyslipidemia in patients requiring further investigations.http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-486-1&slc_lang=en&sid=1 polycystic ovary syndrome Glycyrrhizaglabra L. Blood sugar Triglyceride Cholesterol |
| spellingShingle | F Barazesh A Mirzaei Z Abbasian M Ghavami Zadeh The Effect of Hydroalcoholic Extract of Glycyrrhizaglabra L. (licorice) Root on Serum Level of Glucose, Triglyceride and Cholesterol in Polycystic Ovary Syndrome Induced by Letrozole in Rats Armaghane Danesh Bimonthly Journal polycystic ovary syndrome Glycyrrhizaglabra L. Blood sugar Triglyceride Cholesterol |
| title | The Effect of Hydroalcoholic Extract of Glycyrrhizaglabra L. (licorice) Root on Serum Level of Glucose, Triglyceride and Cholesterol in Polycystic Ovary Syndrome Induced by Letrozole in Rats |
| title_full | The Effect of Hydroalcoholic Extract of Glycyrrhizaglabra L. (licorice) Root on Serum Level of Glucose, Triglyceride and Cholesterol in Polycystic Ovary Syndrome Induced by Letrozole in Rats |
| title_fullStr | The Effect of Hydroalcoholic Extract of Glycyrrhizaglabra L. (licorice) Root on Serum Level of Glucose, Triglyceride and Cholesterol in Polycystic Ovary Syndrome Induced by Letrozole in Rats |
| title_full_unstemmed | The Effect of Hydroalcoholic Extract of Glycyrrhizaglabra L. (licorice) Root on Serum Level of Glucose, Triglyceride and Cholesterol in Polycystic Ovary Syndrome Induced by Letrozole in Rats |
| title_short | The Effect of Hydroalcoholic Extract of Glycyrrhizaglabra L. (licorice) Root on Serum Level of Glucose, Triglyceride and Cholesterol in Polycystic Ovary Syndrome Induced by Letrozole in Rats |
| title_sort | effect of hydroalcoholic extract of glycyrrhizaglabra l licorice root on serum level of glucose triglyceride and cholesterol in polycystic ovary syndrome induced by letrozole in rats |
| topic | polycystic ovary syndrome Glycyrrhizaglabra L. Blood sugar Triglyceride Cholesterol |
| url | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-486-1&slc_lang=en&sid=1 |
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